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3-乙酰氨基四氢-2-噻吩

3-乙酰氨基四氢-2-噻吩用途

Citiolone是半胱氨酸的衍生物,用于治疗肝脏疾病。

3-乙酰氨基四氢-2-噻吩名称

[ CAS 号 ]:
1195-16-0

[ 中文名 ]:
2-乙酰氨基-4-巯基丁酸γ-硫内酯

[ 英文名 ]:
Citiolone

[中文别名 ]:

[英文别名 ]:

EINECS 214-793-8
3-Acetamidotetrahydro-2-thiophenone
N-Acetyl-DL-homocystein thiolactone
MFCD00005480
N-(2-oxothiolan-3-yl)acetamide
2-Acetamido-4-mercaptobutyric Acid γ-Thiolactone
DL-N-Acetylhomocysteine thiolactone
Citiolone

3-乙酰氨基四氢-2-噻吩生物活性

[ 描述 ]:

Citiolone是半胱氨酸的衍生物,用于治疗肝脏疾病。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 其他

[相关活性小分子]

3-乙酰氨基四氢-2-噻吩物理化学性质

[ 密度 ]:
1.263 g/cm3

[ 沸点 ]:
427.265ºC at 760 mmHg

[ 熔点 ]:
109-111ºC

[ 分子式 ]:
C₆H₉NO₂S

[ 分子量 ]:
159.20600

[ 闪点 ]:
212.202ºC

[ 精确质量 ]:
159.03500

[ PSA ]:
71.47000

[ LogP ]:
0.54550

[ 外观性状 ]:
固体;White to Almost white powder to crystal

[ 储存条件 ]:
室温，密封，干燥

3-乙酰氨基四氢-2-噻吩MSDS

详细MSDS(安全技术说明书)

3-乙酰氨基四氢-2-噻吩毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AC8680000

CHEMICAL NAME :: Acetamide, N-(tetrahydro-2-oxo-3-thienyl)-

CAS REGISTRY NUMBER :: 1195-16-0

BEILSTEIN REFERENCE NO. :: 0004338

LAST UPDATED :: 199701

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C6-H9-N-O2-S

MOLECULAR WEIGHT :: 159.22

WISWESSER LINE NOTATION :: T5SVTJ CMV1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1950 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989 Volume(issue)/page/year: 11,362,1989

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 8,72,1958 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X6028 No. of Facilities: 25 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 2440 (estimated) No. of Female Employees: 1459 (estimated)

3-乙酰氨基四氢-2-噻吩安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301

[ 警示性声明 ]:
P301 + P310

[ 个人防护装备 ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T,Xi

[ 风险声明 (欧洲) ]:
R25

[ 安全声明 (欧洲) ]:
22-24/25-45-36-26

[ 危险品运输编码 ]:
UN 2811 6.1/PG 3

[ WGK德国 ]:
3

[ RTECS号 ]:
AC8680000

[ 海关编码 ]:
2934999090

3-乙酰氨基四氢-2-噻吩合成路线

详细合成路线

3-乙酰氨基四氢-2-噻吩上下游产品

3-乙酰氨基四氢-2-噻吩上游产品

3-乙酰氨基四氢-2-噻吩下游产品

3-乙酰氨基四氢-2-噻吩海关

[ 海关编码 ]: 2934999090

[ 中文概述 ]:
2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

3-乙酰氨基四氢-2-噻吩文献

Interleukin-1 beta increases the activity of superoxide dismutase in rat pancreatic islets.

Endocrinology 130(5) , 2851-7, (1992)

The suppressive effects of interleukin-1 beta (IL-1 beta) on the function of pancreatic islets may be related to induction of gene transcription and protein synthesis. Presently, the effects of human ...

Inability of thiol compounds to restore CNS arylsulfatases inhibited by methyl mercury.

Pharmacol. Toxicol. 69(1) , 71-4, (1991)

Arylsulfatase A and B activities have been analysed in different areas of the CNS (olfactory bulbs, cerebral hemispheres, cerebellum, medulla oblongata and spinal cord) during methyl mercuric chloride...

Recurrent fixed drug eruption caused by citiolone.

J. Investig. Allergol. Clin. Immunol. 7(3) , 193-4, (1997)

Citiolone (N-acetylhomocysteinethiolactone) is a thiolic-derived medication frequently used in Spain and in other countries as a mucolytic agent for the treatment of certain hepatic disorders. Mucolyt...

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