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α-高野尻霉素

α-高野尻霉素用途

α-高野尻霉素是一种有效的α-葡萄糖苷酶抑制剂[1]。

α-高野尻霉素名称

[ CAS 号 ]:
119557-99-2

[ 中文名 ]:
α-高野尻霉素

[ 英文名 ]:
a-Homonojirimycin

[中文别名 ]:

[英文别名 ]:

Hnj cpd
MFCD06797112
Homonojirimycin
2,6-Dideoxy-2,6-imino-D-glycero-L-gulo-heptitol
a-Homonojirimycin
α-Homonojirimycin

α-高野尻霉素生物活性

[ 描述 ]:

α-高野尻霉素是一种有效的α-葡萄糖苷酶抑制剂[1]。

[ 相关类别 ]:

研究领域 >> 代谢疾病

[参考文献]

[1]. Geoffrey C. et al. α-Homonojirimycin [2,6-dideoxy-2,6-imino-d-glycero-l-gulo-heptitol] from omphalea diandra L.: isolation and glucosidase inhibtion. 1988, 29(49), 6483-6485.

α-高野尻霉素物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 沸点 ]:
432.0±45.0 °C at 760 mmHg

[ 熔点 ]:
207ºC

[ 分子式 ]:
C₇H₁₅NO₅

[ 分子量 ]:
193.198

[ 闪点 ]:
224.7±19.3 °C

[ 精确质量 ]:
193.095016

[ PSA ]:
113.18000

[ LogP ]:
-2.62

[ 外观性状 ]:
白色-类白色晶体-粉末

[ 蒸汽压 ]:
0.0±2.3 mmHg at 25°C

[ 折射率 ]:
1.583

[ 储存条件 ]:
-20°C

α-高野尻霉素安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

α-高野尻霉素合成路线

详细合成路线

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α-高野尻霉素文献

In vitro inhibition of glycogen-degrading enzymes and glycosidases by six-membered sugar mimics and their evaluation in cell cultures

Bioorg. Chem. 16 , 7330-7336, (2008)

An amyio-1, 6-glucosidase inhibitor enhanced inhibition of hepatic glucose production in combination with glycogen phosphorylase inhibitor. The inhibitory activity of 1-deoxynojirimycin ( 1) toward hu...

Homonojirimycin analogues and their glucosides from Lobelia sessilifolia and Adenophora spp. (Campanulaceae).

Carbohydr. Res. 323(1-4) , 73-80, (2000)

2,6-Dideoxy-7-O-(beta-D-glucopyranosyl) 2,6-imino-D-glycero-L-gulo- heptitol (7-O-beta-D-glucopyranosyl-alpha-homonojirimycin, 1) was isolated from the 50% methanol extract of the whole plant of Lobel...

Eight stereoisomers of homonojirimycin from D-mannose.

Org. Lett. 14(8) , 2050-3, (2012)

Although there are 32 6-azidoheptitols, there are only 16 homonojirimycin (HNJ) stereoisomers. Two epimeric azidoalditols derived from d-mannose allow the synthesis in water of eight stereoisomers of ...

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