2-咪唑烷酮

2-咪唑烷酮用途

【用途一】
用作甲醛捕获剂，精细化学品的中间体，也用于制树脂和配制增塑剂、喷漆、胶粘剂等
【用途二】
用作甲醛捕获剂，去除经2D-树脂、KB树脂、脲醛树酯、三聚氰胺甲醛树脂等整理后织物中残存的甲醛。该品也用作精细化学品的中间体，用于制造树脂、增塑剂、喷漆、胶粘剂等。
【用途三】
2-咪唑烷酮
【120-93-4】
作为美洛西林钠，阿洛西林钠（azlocillin sodium）的中间体，以及抗血吸虫病、杀虫剂的原料，在印染工业中作为脱醛剂等。降低自硬树脂里游离甲醛的含量，祛除织物甲醛

2-咪唑烷酮名称

[ CAS 号 ]:
120-93-4

[ 中文名 ]:
2-咪唑烷酮

[ 英文名 ]:
2-Imidazolidinone

[中文别名 ]:

[英文别名 ]:

imidazolidin-2-one
2-Imidazolidinone
EINECS 204-436-4
Imidazolidone
Ethylenurea
Ethyleneurea
1,3-(ethane-1,2-diyl)urea
N,N'-ethyleneurea
ethylene urea
urea,ethylene

2-咪唑烷酮物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
358.7±11.0 °C at 760 mmHg

[ 熔点 ]:
129-132 °C(lit.)

[ 分子式 ]:
C₃H₆N₂O

[ 分子量 ]:
86.092

[ 闪点 ]:
202.5±19.4 °C

[ 精确质量 ]:
86.048012

[ PSA ]:
41.13000

[ LogP ]:
-1.23

[ 外观性状 ]:
无色至淡黄色,无气味的粉末

[ 蒸汽压 ]:
0.0±0.8 mmHg at 25°C

[ 折射率 ]:
1.447

[ 储存条件 ]:
库房通风低温干燥,与食品原料分开储运

[ 水溶解性 ]:
soluble

2-咪唑烷酮MSDS

详细MSDS(安全技术说明书)

2-咪唑烷酮毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NJ0570000

CHEMICAL NAME :: 2-Imidazolidinone

CAS REGISTRY NUMBER :: 120-93-4

LAST UPDATED :: 199710

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C3-H6-N2-O

MOLECULAR WEIGHT :: 86.11

WISWESSER LINE NOTATION :: T5MVMTJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique. (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France) V.9- 1974- Volume(issue)/page/year: 17,235,1982 ** TUMORIGENIC DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1000 mg/kg

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Blood - tumors

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB223-159 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 15 mg/kg

SEX/DURATION :: male 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females)

REFERENCE :: 85GUAJ "Antifertility Compounds in the Male and Female," Jackson, H., Springfield, IL, Charles C. Thomas, 1966 Volume(issue)/page/year: -,37,1966 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83666 No. of Facilities: 159 (estimated) No. of Industries: 3 No. of Occupations: 11 No. of Employees: 4032 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83666 No. of Facilities: 76 (estimated) No. of Industries: 3 No. of Occupations: 4 No. of Employees: 6452 (estimated) No. of Female Employees: 347 (estimated)

2-咪唑烷酮安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
1

[ RTECS号 ]:
NJ0570000

[ 海关编码 ]:
2933290090

2-咪唑烷酮合成路线

详细合成路线

2-咪唑烷酮上下游产品

2-咪唑烷酮上游产品

2-咪唑烷酮下游产品

2-咪唑烷酮制备

1、以乙二胺和尿素为原料的合成方法

投料比（质量）乙二胺：尿素：助剂=1：（0.8~0.9）：（0.3~0.5）

把尿素、乙二胺及助剂按比例加到反应釜中，慢慢升温至沸腾。0.5h后，继续升温（须控制升温速度），以慢慢回收助剂和过量乙二胺，直到反应温度升至250，总时间控制在约5h。再在250℃下保温2h，然后冷却，重结晶，得白色的2-咪唑烷酮。其熔点为131~134℃，收率大于95%。

2、以乙二胺与尿素为原料的合成方法

投料比（摩尔比）尿素：乙二醇=4：1

在反应釜中分别投入尿素和乙二醇，开启搅拌，并慢慢升温，在6.5h内升至160~180℃；再用3h将反应物升温至240℃。然后在240℃下搅拌反应1h得到粗产品，粗品经简单真空蒸馏得到精品，收率约为25%（以乙二醇计）。

3、以一氧化碳、硫和乙二胺为原料的合成方法

取30g乙二胺、16g硫和30ml甲醇加到1.8L的不锈钢高压釜中，通入一氧化碳直到0.9MPa时停止。升温至100℃反应2h。然后冷却，放空排出硫化氢，用甲醇漂洗残余物，进一步冷却，过滤除去过量的硫。滤液浓缩至75~100ml，冷却，析出结晶，再过滤、干燥，得2-咪唑烷酮22.4g，熔点131℃，收率58%。

4、以光气和乙二胺为原料的合成方法

在装有滴液漏斗、回流冷凝管、通气管和机械搅拌的300ml四口烧瓶中，加入100ml水，12g乙二胺，开启搅拌。将光气以10g/h的速度经通气管通入反应釜内，同时滴加20%氢氧化钠水溶液，反应温度控制在20℃。2h后，停止通光气，并在20℃下继续搅拌1h。反应结束后，减压蒸馏，残留物用氯仿重结晶，收率可达80%以上。熔点131℃。

5、其他合成方法碳酸亚乙酯与氨反应；COS与乙二胺反应；二异氰酸亚乙酯水解；脲基乙酸二乙酯催化加氢等。

2-咪唑烷酮海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

2-咪唑烷酮文献

Computational thermochemistry of six ureas, imidazolidin-2-one, N,N'-trimethyleneurea, benzimidazolinone, parabanic acid, barbital (5,5'-diethylbarbituric acid), and 3,4,4'-trichlorocarbanilide, with an extension to related compounds.

J. Phys. Chem. A 114(34) , 9237-45, (2010)

A computational study of the structural and thermochemical properties of N-phenyl (open) and N-alkyl (cyclic) ureas, through the use of M05-2X and B3LYP density functional theory calculations has been...

Synthesis of new unsymmetrical 4,5-dihydroxy-2-imidazolidinones. Dynamic NMR spectroscopic study of the prototropic tautomerism in 1-(2-benzimidazolyl)-3-phenyl-4,5-dihydroxy-2-imidazolidinone.

Molecules 11(10) , 768-75, (2006)

The acid-catalyzed cyclocondensation in refluxing acetonitrile of aqueous glyoxal with N-heteroaryl-N'-phenylureas 4a-f (heteroaryl = 2-thiazolyl, 2-pyrimidinyl,2-pyrazinyl, 2-pyridinyl, 3-pyridinyl a...

[Preliminary pharmacological evaluation of new imidazolidinone-2, ethylenediamine and imidazoline derivatives].

Acta Pol. Pharm. 41(4) , 495-504, (1984)

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