[Ala1,3,11,15]-内皮素1

[Ala1,3,11,15]-内皮素1用途

[Ala1,3,11,15]-内皮素(53-63)是一种ETB激动剂。[Ala1,3,11,15]-内皮素(53-63)对ETB具有选择性,IC50值范围为0.33 nM至0.61 nM。[Ala1,3,11,15]-内皮素(53-63)可用于血管收缩的研究[1][2]。

[Ala1,3,11,15]-内皮素1名称

[ CAS 号 ]:
121204-87-3

[ 中文名 ]:
[Ala1,3,11,15]-内皮素1

[ 英文名 ]:
(Ala1.3.11.15)-Endothelin-1 trifluoroacetate salt

[中文别名 ]:

[丙氨酸1,3,11,15]-内皮素1

[英文别名 ]:

asasslmdkeavyfahldiiw
MFCD00143562
4 ala et-1

[Ala1,3,11,15]-内皮素1生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 心血管疾病

研究领域 >> 内分泌

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 内皮素受体

[ 靶点 ]

IC50 for ETB: 0.61 nM (Bronchus); 0.61 nM (Lung); 0.33 nM (Cerebellum); 2200 nM (VSMC)[1]

[体外研究]

[Ala1,3,11,15]-内皮素(53-63)(0.1μM)对ETB具有选择性,在支气管、肺、小脑和VSMC中IC50值分别为0.61 nM、0.61 nM、0.33 nM、2200 nM[1]。

[Ala1,3,11,15]-内皮素1物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
2391.5±65.0 °C at 760 mmHg

[ 分子式 ]:
C₁₀₉H₁₆₃N₂₅O₃₂S

[ 分子量 ]:
2367.674

[ 闪点 ]:
1400.1±34.3 °C

[ 精确质量 ]:
2366.161621

[ PSA ]:
933.93000

[ LogP ]:
3.12

[ 蒸汽压 ]:
0.0±0.3 mmHg at 25°C

[ 折射率 ]:
1.586

[ 储存条件 ]:
−20°C

[Ala1,3,11,15]-内皮素1MSDS

详细MSDS(安全技术说明书)

[Ala1,3,11,15]-内皮素1安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[Ala1,3,11,15]-内皮素1文献

Alterations in ET-1, not nitric oxide, in 1-week-old lambs with increased pulmonary blood flow.

Am. J. Physiol. Heart Circ. Physiol. 284(2) , H480-90, (2003)

Altered pulmonary vascular reactivity is a source of morbidity and mortality for children with congenital heart disease and increased pulmonary blood flow. Nitric oxide (NO) and endothelin (ET)-1 are ...

Endothelin receptor blockade does not alter the increase in pulmonary blood flow due to oxygen ventilation in fetal lambs.

Pediatr. Res. 40(1) , 152-7, (1996)

At birth, pulmonary vasodilation occurs during rhythmic distension of the lungs with oxygen. Both mechanical and humoral factors are involved, including the release of vasoactive substances such as pr...

Production of monocyte chemoattractant protein-1 and cytokine-induced neutrophil chemoattractant-1 in rat brain is stimulated by intracerebroventricular administration of an endothelin ETB receptor agonist.

Neuroreport 18(12) , 1275-9, (2007)

The role of endothelin (ET)B receptors in chemokine production in the brain of rats was examined. Intracerebroventricular administration of 500 pmol/day of Ala(1,3,11,15)-ET-1, a selective ETB agonist...

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