聚钨酸钠

聚钨酸钠用途

POM1是一种有效的、外核苷三磷酸二磷酸水解酶 (NTPDase) 的抑制剂,其对NTPDase 1、NTPDase 3 和 NTPDase 2 的 Ki 值分别为2.58 μM、3.26 μM 和 28.8 μM。POM1 能够抑制 ATP 的分解,并阻断中枢突触传递,这是独立于抑制NTPDase 而发挥作用的。

聚钨酸钠名称

[ CAS 号 ]:
12141-67-2

[ 中文名 ]:
聚钨酸钠

[ 英文名 ]:
POM 1

[中文别名 ]:

[英文别名 ]:

SODIUM POLYTUNGSTATE
POM 1
4-Acetyl-1,1-dimethylpiperazinium iodide
Sodium metatungstate monohydrate
EINECS 412-770-9
Sodium metatungstate
SODIUM POLYTINGSTATE
hexasodium tungstate hydrate
Sodium polytungstate solution
TUNGSTATEHEXASODIUM

聚钨酸钠生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 神经疾病

[ 靶点 ]

Ki: 2.58 μM (NTPDase 1), 3.26 μM (NTPDase 3), 28.8 μM (NTPDase 2)[1].

[参考文献]

[1]. Müller CE, et al. Polyoxometalates--a new class of potent ecto-nucleoside triphosphate diphosphohydrolase (NTPDase) inhibitors. Bioorg Med Chem Lett. 2006 Dec 1;16(23):5943-7.

[2]. Wall et al. The novel NTPDase inhibitor sodium polyoxotungstate (POM-1) inhibits ATP breakdown but also blocks central synaptic transmission, an action independent of NTPDase inhibition. Neuropharmacology. 2008 Dec;55(7):1251-8.

聚钨酸钠物理化学性质

[ 密度 ]:
3.1 g/cm3

[ 分子式 ]:
H₂Na₆O₄₀W₁₂

[ 分子量 ]:
2986.01

[ 精确质量 ]:
2969.15000

[ PSA ]:
701.67000

[ 外观性状 ]:
白色-灰色

[ 折射率 ]:
n20/D 1.5555

[ 储存条件 ]:
Store at RT

[ 水溶解性 ]:
Soluble in water.

聚钨酸钠MSDS

详细MSDS(安全技术说明书)

聚钨酸钠安全信息

[ 符号 ]:

GHS05

[ 信号词 ]:
Danger

[ 危害声明 ]:
H318-H412

[ 警示性声明 ]:
P273-P280-P305 + P351 + P338

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
R22

[ 安全声明 (欧洲) ]:
26-39-61

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

聚钨酸钠文献

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Regulatory T cell-derived adenosine induces dendritic cell migration through the Epac-Rap1 pathway.

J. Immunol. 194(8) , 3735-44, (2015)

Dendritic cells (DC) are one target for immune suppression by regulatory T cells (Treg), because their interaction results in reduced T cell stimulatory capacity and secretion of inhibitory cytokines ...

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