Pilocarpine-d3 hydrochloride

Pilocarpine-d3 hydrochloride用途

匹罗卡品-d3(盐酸盐)是氘标记的匹罗卡品(盐酸盐)。盐酸毛果芸香碱是一种有效的M3型毒蕈碱乙酰胆碱受体(M3毒蕈碱受体)激动剂。

Pilocarpine-d3 hydrochloride名称

[ CAS 号 ]:
1217838-88-4

[ 英文名 ]:
Pilocarpine-d3 hydrochloride

Pilocarpine-d3 hydrochloride生物活性

[ 描述 ]:

匹罗卡品-d3(盐酸盐)是氘标记的匹罗卡品(盐酸盐)。盐酸毛果芸香碱是一种有效的M3型毒蕈碱乙酰胆碱受体(M3毒蕈碱受体)激动剂。

[ 相关类别 ]:

信号通路 >> 神经信号通路 >> mAChR

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 由mAChR

研究领域 >> 神经疾病

[体外研究]

氢、碳和其他元素的稳定重同位素已被纳入药物分子中,主要作为药物开发过程中定量的示踪剂。氘化因其可能影响药物的药代动力学和代谢特征而受到关注[1]。

[参考文献]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Matsuzaki K, et al. Daily voluntary exercise enhances pilocarpine-induced saliva secretion and aquaporin 1 expression in rat submandibular glands. FEBS Open Bio. 2017 Dec 7;8(1):85-93.

[3]. Tonta MA, et al. Pilocarpine-induced relaxation of rat tail artery by a non-cholinergic mechanism and in the absence of an intact endothelium. Br J Pharmacol. 1994 Jun;112(2):525-32.

[4]. Wang RF, et al. Post-treatment with the GLP-1 analogue liraglutide alleviate chronic inflammation and mitochondrial stress induced by Status epilepticus. Epilepsy Res. 2018 Mar 9;142:45-52.

[5]. Yuan XL, et al. Cytotoxicity of pilocarpine to human corneal stromal cells and its underlying cytotoxic mechanisms. Int J Ophthalmol. 2016 Apr 18;9(4):505-11.

Pilocarpine-d3 hydrochloride物理化学性质

[ 分子式 ]:
C₁₁H₁₄D₃ClN₂O₂

[ 分子量 ]:
247.74

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相关化合物

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