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莫匹罗星

莫匹罗星用途

【用途一】
局部用抗生素。通过可逆地结合于异亮氨酸转移RNA合成酶，阻止异亮氨酸参人，从而使细胞内含异亮氨酸的所有蛋白质的合成停止。用于急性原发性皮肤细菌感染，如毛囊炎、脓疱病。

莫匹罗星名称

[ CAS 号 ]:
12650-69-0

[ 中文名 ]:
莫匹罗星

[ 英文名 ]:
Mupirocin

[中文别名 ]:

[英文别名 ]:

Pseudomonic acid
Bactoderm
MFCD03792664
Pseudomonic acid A
Mupirocin
EINECS 231-791-2
Turixin
BACTROBAN
Mupirocin [USAN:BAN:INN]
Mupirocina

莫匹罗星生物活性

[ 描述 ]:

莫匹罗星(Mupirocin)是一抗生素化合物。

[ 相关类别 ]:

信号通路 >> 抗感染 >> 细菌

研究领域 >> 感染

[参考文献]

[1]. Hughes J, et al. Inhibition of isoleucyl-transfer ribonucleic acid synthetase in Escherichia coli by pseudomonic acid. Biochem J. 1978 Oct 15;176(1):305-18.

[2]. Cookson BD. The emergence of mupirocin resistance: a challenge to infection control and antibiotic prescribing practice. J Antimicrob Chemother. 1998 Jan;41(1):11-8.

[相关活性小分子]

莫匹罗星物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
672.3±55.0 °C at 760 mmHg

[ 熔点 ]:
77-780C

[ 分子式 ]:
C₂₆H₄₄O₉

[ 分子量 ]:
500.622

[ 闪点 ]:
216.5±25.0 °C

[ 精确质量 ]:
500.298523

[ PSA ]:
146.05000

[ LogP ]:
3.44

[ 外观性状 ]:
固体

[ 蒸汽压 ]:
0.0±4.7 mmHg at 25°C

[ 折射率 ]:
1.524

[ 储存条件 ]:
-20°C Freezer, Under Inert Atmosphere

[ 水溶解性 ]:
H2O: 12 mg/mL, soluble

莫匹罗星安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 安全声明 (欧洲) ]:
S2

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
RA6907000

[ 海关编码 ]:
2941909000

莫匹罗星合成路线

详细合成路线

莫匹罗星上下游产品

莫匹罗星上游产品

莫匹罗星下游产品

莫匹罗星制备

由荧光假单胞菌产生的一类物质，包括假单胞菌酸A、B、C、D，莫匹罗星即其中的主要代谢物假单胞菌酸A。

莫匹罗星海关

[ 海关编码 ]: 2941909000

莫匹罗星文献

Purification and characterization of the Staphylococcus aureus bacillithiol transferase BstA.

Biochim. Biophys. Acta 1840(9) , 2851-61, (2014)

Gram-positive bacteria in the phylum Firmicutes synthesize the low molecular weight thiol bacillithiol rather than glutathione or mycothiol. The bacillithiol transferase YfiT from Bacillus subtilis wa...

Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

J. Sci. Ind. Res. 65(10) , 808, (2006)

Drug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI typ...

Simultaneous monitoring of Staphylococcus aureus growth in a multi-parametric microfluidic platform using microscopy and impedance spectroscopy.

Bioelectrochemistry 105 , 56-64, (2015)

We describe the design, construction, and characterization of a scalable microfluidic platform that allows continuous monitoring of biofilm proliferation under shear stress conditions. Compared to oth...

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