核糖

核糖用途

D-Ribose(mixture of isomers) 是一种能量增强剂,为 ATP 的糖部分,广泛用作慢性疲劳综合症和心肌能量代谢的代谢疗法补充剂。D-Ribose(mixture of isomers) 在蛋白质糖化中具有活性,能够以 RAGE 依赖的方式诱导 NF-κB 炎症。

核糖名称

[ CAS 号 ]:
50-69-1

[ 中文名 ]:
D-核糖

[ 英文名 ]:
D-Ribose

[中文别名 ]:

[英文别名 ]:

RIBOSE,D-(-)
FEMA 3793
EINECS 200-059-4
D-RIB
(2R,3R,4R)-2,3,4,5-Tetrahydroxypentanal
D-Ribose
d-ribos
D-(-)-RIBOSE
Ribose (300 mg)
R-RIBOSE

核糖生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 炎症/免疫

[体外研究]

D-核糖(异构体的混合物)是能量增强剂,并且充当ATP的糖部分,并且广泛用作慢性疲劳综合征或心脏能量代谢的代谢疗法补充剂[1]。 D-核糖(异构体混合物)在蛋白质糖化中具有活性,以RAGE依赖性方式诱导NF-κB炎症[1]。

[参考文献]

[1]. Hong J, et al. D-ribose induces nephropathy through RAGE-dependent NF-κB inflammation. Arch Pharm Res. 2018 Aug;41(8):838-847.

核糖物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 沸点 ]:
415.5±38.0 °C at 760 mmHg

[ 熔点 ]:
88-92ºC

[ 分子式 ]:
C₅H₁₀O₅

[ 分子量 ]:
150.13

[ 闪点 ]:
219.2±23.3 °C

[ 精确质量 ]:
150.052826

[ PSA ]:
97.99000

[ LogP ]:
-2.39

[ 外观性状 ]:
白色至灰白色结晶粉末

[ 蒸汽压 ]:
0.0±2.2 mmHg at 25°C

[ 折射率 ]:
1.544

[ 储存条件 ]:
存放于惰性气体之中;避免湿气 (吸湿)

[ 水溶解性 ]:
水溶性：完全溶解；水溶解度：700 g/l 20 °C；微溶：醇；不溶：乙醚,氯仿

核糖MSDS

核糖毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VJ2275000

CHEMICAL NAME :: Ribose, D-

CAS REGISTRY NUMBER :: 50-69-1

BEILSTEIN REFERENCE NO. :: 1723081

LAST UPDATED :: 199801

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C5-H10-O5

MOLECULAR WEIGHT :: 150.15

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intrauterine

DOSE :: 5045 ug/kg

SEX/DURATION :: female 2 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)

MUTATION DATA

TYPE OF TEST :: Mutation test systems - not otherwise specified

TEST SYSTEM :: Human Lymphocyte

DOSE/DURATION :: 30 mmol/L

REFERENCE :: PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 180,246,1985 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X1001 No. of Facilities: 439 (estimated) No. of Industries: 2 No. of Occupations: 8 No. of Employees: 4169 (estimated) No. of Female Employees: 2111 (estimated)

核糖安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
F

[ 风险声明 (欧洲) ]:
R36/38

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
VJ2275000

[ 海关编码 ]:
2940000000

核糖合成路线

核糖上下游产品

核糖上游产品

核糖下游产品

核糖制备

以D-葡萄糖为原料，接入细菌或枯草杆菌进行发酵，由发酵生成物进行分离、精制而得。

保藏菌种→活化斜面→种子罐培养→发酵→发酵液→

絮凝→上清液→阳离子树脂交换→活性炭脱色→浓缩

→精制→结晶→产品

核糖海关

[ 海关编码 ]: 2912491000

[ 中文概述 ]:
2912491000. 醛醇. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:5.5%. 普通关税:30.0%

[ Summary ]:
2912491000. other aldehyde-alcohols. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%

核糖文献

High-throughput electrophoretic mobility shift assays for quantitative analysis of molecular binding reactions.

Anal. Chem. 86(20) , 10357-64, (2014)

We describe a platform for high-throughput electrophoretic mobility shift assays (EMSAs) for identification and characterization of molecular binding reactions. A photopatterned free-standing polyacry...

TLR signaling modulates side effects of anticancer therapy in the small intestine.

J. Immunol. 194(4) , 1983-95, (2015)

Intestinal mucositis represents the most common complication of intensive chemotherapy, which has a severe adverse impact on quality of life of cancer patients. However, the precise pathophysiology re...

Simplified in vitro refolding and purification of recombinant human granulocyte colony stimulating factor using protein folding cation exchange chromatography.

J. Chromatogr. A. 1379 , 74-82, (2015)

Protein folding-strong cation exchange chromatography (PF-SCX) has been employed for efficient refolding with simultaneous purification of recombinant human granulocyte colony stimulating factor (rhG-...

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核糖