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混合甲酚

混合甲酚用途

Cresol是一种有机化合物,是芳香族有机化合物广泛存在的天然及合成基团。

混合甲酚名称

[ CAS 号 ]:
1319-77-3

[ 中文名 ]:
甲酚

[ 英文名 ]:
Cresol

[中文别名 ]:

甲酚异构体混合物

[英文别名 ]:

hydroxytoluene
Cresol, o-
tekresol
Cresol, ortho-
2-hydroxytoluene
Phenol, 2-methyl-
bacillol
m-cresol,p-cresol,mixture of
o-Methylphenol
ortho-cresol

混合甲酚生物活性

[ 描述 ]:

Cresol是一种有机化合物,是芳香族有机化合物广泛存在的天然及合成基团。

[ 相关类别 ]:

信号通路 >> 自噬 >> 自噬

研究领域 >> 其他

[相关活性小分子]

混合甲酚物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
191.0±0.0 °C at 760 mmHg

[ 熔点 ]:
-1--2°C

[ 分子式 ]:
C₇H₈O

[ 分子量 ]:
108.138

[ 闪点 ]:
81.1±0.0 °C

[ 精确质量 ]:
108.057518

[ PSA ]:
60.69000

[ LogP ]:
1.94

[ 外观性状 ]:
淡黄色至淡粉红色液体

[ 蒸汽压 ]:
0.4±0.3 mmHg at 25°C

[ 折射率 ]:
1.546

[ 储存条件 ]:
库房通风低温干燥,与氧化剂分开存放

[ 稳定性 ]:
Stable. Combustible. Incompatible with strong oxidizing agents.

[ 水溶解性 ]:
1.932 g/100 mL

混合甲酚MSDS

详细MSDS(安全技术说明书)

混合甲酚毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GO5950000

CHEMICAL NAME :: Cresol

CAS REGISTRY NUMBER :: 1319-77-3

BEILSTEIN REFERENCE NO. :: 0506719

LAST UPDATED :: 199712

DATA ITEMS CITED :: 44

MOLECULAR FORMULA :: C7-H8-O

MOLECULAR WEIGHT :: 108.15

WISWESSER LINE NOTATION :: QR X1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 177 mg/kg

TOXIC EFFECTS :: Blood - other hemolysis with or without anemia Blood - other changes

REFERENCE :: CMAJAX Canadian Medical Association Journal. (Canadian Medical Assoc., POB 8650, Ottawa, ON K1G 0G8, Canada) V.1- 1911- Volume(issue)/page/year: 130,1319,1984

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human

DOSE/DURATION :: 114 mg/kg

TOXIC EFFECTS :: Vascular - other changes

REFERENCE :: 85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989 Volume(issue)/page/year: 11,404,1989

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1454 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB214-270

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 760 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: KSGZA3 Kyushu Shika Gakkai Zasshi. Journal of the Kyushu Dental Society. (c/o Kyushu Shika Daigaku, 2-6-1 Manazuru, Kokurakita-ku, Kitakyushu, Japan) V.1- 1933- Suspended 1941-50. Volume(issue)/page/year: 36,932,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 2 gm/kg

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 42,417,1977 *** REVIEWS *** ACGIH TLV-TWA 22 mg/m3 (5 ppm) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 MSHA STANDARD:skin 5 ppm (22 mg/m3) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,61,1971 OSHA PEL (Gen Indu):8H TWA 5 ppm (22 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 5 ppm (22 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 5 ppm (22 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 5 ppm (22 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-ARAB Republic of Egypt:TWA 5 ppm (23 mg/m3) JAN 1993 OEL-AUSTRALIA:TWA 5 ppm (22 mg/m3);Skin JAN 1993 OEL-BELGIUM:TWA 5 ppm (22 mg/m3);Skin JAN 1993 OEL-DENMARK:TWA 5 ppm (22 mg/m3);Skin JAN 1993 OEL-FINLAND:TWA 5 ppm (22 mg/m3);STEL 10 ppm (44 mg/m3);Skin JAN 1993 OEL-FRANCE:TWA 5 ppm (22 mg/m3);Skin JAN 1993 OEL-GERMANY:TWA 5 ppm (22 mg/m3);Skin JAN 1993 OEL-HUNGARY:TWA 5 mg/m3;STEL 10 mg/m3 JAN 1993 OEL-INDIA:TWA 5 ppm (22 mg/m3);Skin JAN 1993 OEL-JAPAN:TWA 5 ppm (22 mg/m3);Skin JAN 1993 OEL-THE NETHERLANDS:TWA 5 ppm (22 mg/m3);Skin JAN 1993 OEL-THE PHILIPPINES:TWA 5 ppm (22 mg/m3);Skin JAN 1993 OEL-POLAND:TWA 5 mg/m3 JAN 1993 OEL-RUSSIA:TWA 5 ppm;STEL 0.5 mg/m3;Skin JAN 1993 OEL-SWITZERLAND:TWA 5 ppm (22 mg/m3);STEL 10 ppm (44 mg/m3);Skin JAN 1993 OEL-TURKEY:TWA 5 ppm (22 mg/m3);Skin JAN 1993 OEL-UNITED KINGDOM:TWA 5 ppm (22 mg/m3);Skin JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO CRESOL, all isomers-air:10H TWA 2.3 ppm REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 20380 No. of Facilities: 8215 (estimated) No. of Industries: 86 No. of Occupations: 78 No. of Employees: 71952 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 20380 No. of Facilities: 7461 (estimated) No. of Industries: 84 No. of Occupations: 65 No. of Employees: 132742 (estimated) No. of Female Employees: 28184 (estimated)

混合甲酚安全信息

[ 符号 ]:

GHS05, GHS06, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301 + H311-H314-H341-H412

[ 警示性声明 ]:
P201-P280-P301 + P310 + P330-P303 + P361 + P353-P304 + P340 + P310-P305 + P351 + P338

[ 个人防护装备 ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
T:Toxic

[ 风险声明 (欧洲) ]:
R20;R24/25;R34;R52/53;R68

[ 安全声明 (欧洲) ]:
S26-S36/37/39-S45-S61

[ 危险品运输编码 ]:
UN 2076 6.1/PG 2

[ WGK德国 ]:
1

[ RTECS号 ]:
GO5950000

[ 包装等级 ]:
II

[ 危险类别 ]:
6.1(a)

[ 海关编码 ]:
2707991000

混合甲酚制备

合成甲酚的方法有多种，各种方法得到的产品中异构体的含量也有所不同。

1. 甲苯磺化法该法与苯磺化制苯酚的过程相类似。首先将甲苯磺化得到甲苯磺酸，而后用氢氧化钠处理熔融的磺化物，得到甲酚钠盐。将钠盐与水混合，通入二氧化硫或加入硫酸酸化得到甲酚。在低真空度下蒸去粗甲酚的水分后，再在（80-93.3kPa）的真空度下，收集150-200℃馏分得混合甲酚。其中邻、间、对三种异构体的比例随反应条件而异，一般情况下，对位最多，间位较少，邻位更少。该法生产每吨混甲酚消耗甲苯1374kg，30%液碱5000多kg。

2. 甲基异丙基苯氧化法这是美国赫格里斯炸药公司采用的方法。甲苯用丙烯进行烷基化，得到间、对、位异构体比例为2.5-3：1的甲基异丙苯混合物，其中邻位异构体很少。然后在25-35℃通入含氧气体，将甲基异丙苯氧化为甲基异丙基苯过氧化物，再经硫酸处理，得到富含间、对位异构体的甲酚，同时联产丙酮。该法与异丙苯法生产苯酚和丙酮的工艺相似。

3.煤焦油分馏法由高温炼焦副产粗酚经分馏而得。

混合甲酚海关

[ 海关编码 ]: 2707991000

混合甲酚文献

Purification and characterization of active-site components of the putative p-cresol methylhydroxylase membrane complex from Geobacter metallireducens.

J. Bacteriol. 190(19) , 6493-500, (2008)

p-Cresol methylhydroxylases (PCMH) from aerobic and facultatively anaerobic bacteria are soluble, periplasmic flavocytochromes that catalyze the first step in biological p-cresol degradation, the hydr...

On the decoupling of relaxation modes in a molecular liquid caused by isothermal introduction of 2 nm structural inhomogeneities.

J. Phys. Chem. B 115(48) , 13994-9, (2011)

To support a new interpretation of the origin of the dynamic heterogeneity observed pervasively in fragile liquids as they approach their glass transition temperatures T(g), we demonstrate that the in...

Cresols utilization by Trametes versicolor and substrate interactions in the mixture with phenol.

Biodegradation 21(4) , 625-35, (2010)

The ability of the white rot fungus Trametes versicolor strain 1 to degrade and utilize methylated phenols (cresols) was established for the first time in a medium not containing any other carbon comp...

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