硫酸洛贝林

硫酸洛贝林用途

Lobeline sulfate (α-Lobeline sulfate; L-Lobeline sulfate) 是一种非兴奋性试剂,可以改变大脑中多巴胺的吸收。 Lobeline sulfate (α-Lobeline sulfate; L-Lobeline sulfate) 可以抑制尼古丁引起的机能亢进并有助于有效戒烟。

硫酸洛贝林名称

[ CAS 号 ]:
134-64-5

[ 中文名 ]:
硫酸山梗菜碱

[ 英文名 ]:
Lobeline sulfate

[中文别名 ]:

[英文别名 ]:

Lobeline sulfate
EINECS 205-151-8
MFCD00135592

硫酸洛贝林生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 神经疾病

[ 靶点 ]

IC50: endogenous metabolite[1]

[参考文献]

[1]. Robert J. Laffan, et al.EMETIC ACTION OF NICOTINE AND LOBELINE. Journal of Pharmacology and Experimental Therapeutics December 1957, 121 (4) 468-476

[2]. https://mayoclinic.pure.elsevier.com/en/publications/a-smoking-cessation-trial-with-lobeline-sulfate-a-pilot-st

硫酸洛贝林物理化学性质

[ 密度 ]:
1.085g/cm3

[ 沸点 ]:
485.6ºC at 760mmHg

[ 熔点 ]:
152-154 °C

[ 分子式 ]:
C₄₄H₅₆N₂O₈S

[ 分子量 ]:
772.98900

[ 闪点 ]:
247.5ºC

[ 精确质量 ]:
772.37600

[ PSA ]:
164.06000

[ LogP ]:
8.77580

[ 外观性状 ]:
白色粉末

[ 蒸汽压 ]:
3.05E-10mmHg at 25°C

硫酸洛贝林MSDS

详细MSDS(安全技术说明书)

硫酸洛贝林毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: OJ8490170

CAS REGISTRY NUMBER :: 134-64-5

LAST UPDATED :: 198609

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C22-H27-N-O2.1/2H2-O4-S

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 55300 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: VHTODE Veterinary and Human Toxicology. (American College of Veterinary and Comparative Toxicology, Publication Office, Comparative Toxicology, Manhattan, KS 66506) V.19- 1977- Volume(issue)/page/year: 27,1,1985

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Bird - pigeon

DOSE/DURATION :: 54600 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FDWU** "Ueber die Wirkung Verschiedener Gifte Auf Vogel, Dissertation," Forchheimer, L., Pharmakologischen Institut der Universitat Wurzburg, Fed. Rep. Ger., 1931 Volume(issue)/page/year: -,-,1931

硫酸洛贝林安全信息

[ 危害码 (欧洲) ]:
T:Toxic;

[ 风险声明 (欧洲) ]:
R23/24/25

[ 安全声明 (欧洲) ]:
S45-S38-S36/37/39-S28A

[ 危险品运输编码 ]:
2811

[ RTECS号 ]:
OJ8490170

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1

[ 海关编码 ]:
2933399090

硫酸洛贝林海关

[ 海关编码 ]: 2933399090

[ 中文概述 ]:
2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%