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唑螨酯

唑螨酯用途

(E) -苯吡肟是一种有效的杀螨剂[1]。

唑螨酯名称

[ CAS 号 ]:
134098-61-6

[ 中文名 ]:
唑螨酯

[ 英文名 ]:
Fenpyroximate

[中文别名 ]:

杀螨王

[英文别名 ]:

Trophloabul
DANITORON
Fenpyroximate
uate
MFCD00274596
fenproximate
ORTUS
KIRON
nni850
DANITRON

唑螨酯生物活性

[ 描述 ]:

(E) -苯吡肟是一种有效的杀螨剂[1]。

[ 相关类别 ]:

研究领域 >> 感染

[参考文献]

[1]. Motoba. K, et al. Species-specific detoxification metabolism of fenpyroximate, a potent acaricide.

唑螨酯物理化学性质

[ 密度 ]:
1.13 g/cm3

[ 沸点 ]:
546.2ºC at 760 mmHg

[ 熔点 ]:
99-102°C

[ 分子式 ]:
C₂₄H₂₇N₃O₄

[ 分子量 ]:
421.48900

[ 闪点 ]:
284.1ºC

[ 精确质量 ]:
421.20000

[ PSA ]:
74.94000

[ LogP ]:
5.02680

[ 外观性状 ]:
白色结晶粉末

[ 储存条件 ]:
室温，干燥，密封

唑螨酯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DG9081200

CHEMICAL NAME :: Benzoic acid, 4-(((((1,3-dimethyl-5-phenoxy-1H-pyrazol-4-yl)methyle ne)amino)oxy)methyl)-, 1,1-dimethylethyl ester, (E)-

CAS REGISTRY NUMBER :: 134098-61-6

LAST UPDATED :: 199607

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C24-H27-N3-O4

MOLECULAR WEIGHT :: 421.54

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 245 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 17,S261,1992

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 330 mg/m3/4H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 17,S261,1992

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 17,S261,1992

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 440 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 17,S261,1992 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2730 mg/kg/13W-C

TOXIC EFFECTS :: Liver - other changes Kidney, Ureter, Bladder - urine volume decreased Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases

REFERENCE :: NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 17,S261,1992

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 6552 mg/kg/2Y-C

TOXIC EFFECTS :: Behavioral - food intake (animal) Kidney, Ureter, Bladder - urine volume decreased Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 17,S261,1992

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 4550 mg/kg/13W-I

TOXIC EFFECTS :: Cardiac - change in rate Liver - changes in liver weight

REFERENCE :: NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 17,S261,1992

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 5460 mg/kg/52W-I

TOXIC EFFECTS :: Cardiac - EKG changes not diagnostic of specified effects Cardiac - change in rate Gastrointestinal - hypermotility, diarrhea

REFERENCE :: NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 17,S261,1992

唑螨酯安全信息

[ 危害码 (欧洲) ]:
Xn;N

[ 风险声明 (欧洲) ]:
R36/37/38:Irritating to eyes, respiratory system and skin .

[ 安全声明 (欧洲) ]:
S26-S36/37/39

[ WGK德国 ]:
3.0

[ 危险类别 ]:
9.0

[ 海关编码 ]:
2942000000

唑螨酯制备

1、 5-氯-1，3-二甲基-4-吡唑甲醛的制备先用乙酰乙酸乙酯与甲肼作用，生成1，3-二甲基吡唑-5-酮。然后加入到三氯氧磷-二甲基甲酰胺溶液中。于110～115℃反应8h，得5-氯-1，3-二甲基-4-吡唑甲醛。

2、 1，3-二甲基-5-苯氧基-4-吡唑甲醛的制备先将苯酚、甲醇钠的甲醇溶液加热回流，蒸出甲醇，加入DMF和上步反应产物，于100℃反应4h，减压回收DMF后，冷却、加水、用二氯乙烷萃取，得1，3-二甲基-5-苯氧基-4-吡唑甲醛。

3、 1,3-二甲基-5-苯氧基-4-吡唑甲醛肟的制备将上步产物溶于甲醇中，加入盐酸羟胺，在搅拌下加入氢氧化钾溶液，于60℃反应1h，减压蒸去甲醇，水洗干燥后得白色1，3-二甲基-5-苯氧基-4-吡唑甲醛肟。

4、唑螨酯的合成将上步产物与4-溴甲基苯甲酸特丁酯（合成方法参见特开昭63-183564， 63-267754）在丙酮溶剂中，加入适量碳酸钾，回流反应8h得唑螨酯，目的产物为反式异构体。

唑螨酯海关

[ 海关编码 ]: 2942000000

唑螨酯