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脱水穿心莲内酯

脱水穿心莲内酯用途

脱水穿心莲内酯(Dehydroandrographolide)是从中草药穿心莲提取的天然化合物,具有抗感染活性。

脱水穿心莲内酯名称

[ CAS 号 ]:
134418-28-3

[ 中文名 ]:
脱水穿心莲内酯

[ 英文名 ]:
Dehydroandrographolide

[中文别名 ]:

[英文别名 ]:

Dehydroanddrographolide
2(3H)-Furanone,3-[2-[(1S,4aS,5R,6R,8aS)-decahydro
DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE
Dehydroandrographoline
ANDROGRAPHOLIDE,DEHYDRO
14-Deoxy-11-dehydroandrographolide
Dehydrographkide

脱水穿心莲内酯生物活性

[ 描述 ]:

脱水穿心莲内酯(Dehydroandrographolide)是从中草药穿心莲提取的天然化合物,具有抗感染活性。

[ 相关类别 ]:

信号通路 >> 抗感染 >> 流感病毒

天然产物 >> 萜类化合物和糖苷

研究领域 >> 感染

[参考文献]

[1]. Chen Q, et al. Pharmacokinetics and tolerance of dehydroandrographolide succinate injection after intravenous administration in healthy Chinese volunteers. Acta Pharmacol Sin. 2012 Oct;33(10):1332-6.

[2]. Chao WW, et al. Isolation and identification of bioactive compounds in Andrographis paniculata (Chuanxinlian). Chin Med. 2010 May 13;5:17.

[3]. Basak A, et al. Inhibition of proprotein convertases-1, -7 and furin by diterpines of Andrographis paniculata and their succinoyl esters. Biochem J. 1999 Feb 15;338 ( Pt 1):107-13.

[4]. Zhu T, et al. Dehydroandrographolide succinate inhibits oxidative stress in mice with lipopolysaccharide-induced acute lung injury by inactivating iNOS. Nan Fang Yi Ke Da Xue Xue Bao. 2012 Sep;32(9):1238-41.

[5]. Chen H, et al. Synthesis, structure-activity relationships and biological evaluation of dehydroandrographolide and andrographolide derivatives as novel anti-hepatitis B virus agents. Bioorg Med Chem Lett. 2014 May 15;24(10):2353-9.

[相关活性小分子]

脱水穿心莲内酯物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
512.8±50.0 °C at 760 mmHg

[ 分子式 ]:
C₂₀H₂₈O₄

[ 分子量 ]:
332.43

[ 闪点 ]:
178.3±23.6 °C

[ PSA ]:
86.99000

[ LogP ]:
2.97

[ 蒸汽压 ]:
0.0±3.0 mmHg at 25°C

[ 折射率 ]:
1.584

[ 储存条件 ]:
室温

脱水穿心莲内酯安全信息

[ 危害码 (欧洲) ]:
Xi

[ 安全声明 (欧洲) ]:
24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
LU3490300

脱水穿心莲内酯

脱水穿心莲内酯用途

脱水穿心莲内酯名称

脱水穿心莲内酯生物活性

脱水穿心莲内酯物理化学性质

脱水穿心莲内酯安全信息

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