N-苯基-2-萘胺

N-苯基-2-萘胺用途

【用途一】
适用于天然橡胶、合成橡胶和胶乳
【用途二】
该品是天然橡胶、二烯类合成橡胶、氯丁橡胶及基胶乳用通用型防老剂。对热、氧、屈挠及一般老化有良好的防护作用，并稍优于防老剂甲。对有害金属有抑制作用，但较防老剂甲弱。若与防老剂4010或4010NA并用，则抗热、氧、屈挠龟裂，以及抗臭氧性均有显著提高。本品对天然胶、丁腈胶、丁苯胶的硫化速度无甚影响，对氯丁胶则稍有迟延作用。本品在干胶中容易分解，亦容易分散于水中。本品在橡胶中的溶解度约1.5%，用量不超过1份不会发生喷霜。该品有污染性，在日光下渐变为灰黑色，故不适用于白色或浅色制品。主要用于制造轮胎、胶管、胶带、胶辊、胶鞋、电线电缆绝缘层等工业制品。防老剂丁还可作各种合成橡胶后处理和贮存时的稳定剂，可用作聚甲醛的抗热防老剂。该品对皮肤有一定的刺激性。
【用途三】
检验氯酸盐。有机合成。染料中间体。用作橡胶抗氧剂、润滑剂、聚合抑制剂。

N-苯基-2-萘胺名称

[ CAS 号 ]:
135-88-6

[ 中文名 ]:
N-苯基-2-萘胺

[ 英文名 ]:
N-Phenyl-2-naphthylamine

[中文别名 ]:

[英文别名 ]:

N-Phenyl-2-naphthylamine
2-Naphthalenamine, N-phenyl-
MFCD00004052
N-(2-Naphthyl)aniline
N-Phenyl-2-naphthalenamine
2-Anilinonaphthalene
N-phenylnaphthalen-2-amine
EINECS 205-223-9

N-苯基-2-萘胺物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
395.5±0.0 °C at 760 mmHg

[ 熔点 ]:
105-108 °C(lit.)

[ 分子式 ]:
C₁₆H₁₃N

[ 分子量 ]:
219.281

[ 闪点 ]:
209.2±14.7 °C

[ 精确质量 ]:
219.104797

[ PSA ]:
12.03000

[ LogP ]:
4.20

[ 外观性状 ]:
淡灰色粉末或晶体

[ 蒸汽压 ]:
0.0±0.9 mmHg at 25°C

[ 折射率 ]:
1.702

[ 储存条件 ]:
-20°C

[ 稳定性 ]:
Stable. Incompatible with oxidizing agents.

[ 水溶解性 ]:
Insoluble.

N-苯基-2-萘胺MSDS

详细MSDS(安全技术说明书)

N-苯基-2-萘胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QM4550000

CHEMICAL NAME :: 2-Naphthylamine, N-phenyl-

CAS REGISTRY NUMBER :: 135-88-6

BEILSTEIN REFERENCE NO. :: 2211188

LAST UPDATED :: 199712

DATA ITEMS CITED :: 37

MOLECULAR FORMULA :: C16-H13-N

MOLECULAR WEIGHT :: 219.30

WISWESSER LINE NOTATION :: L66J CMR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 8730 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity)

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 8700 mg/kg

TOXIC EFFECTS :: Brain and Coverings - other degenerative changes Lungs, Thorax, or Respiration - acute pulmonary edema Liver - other changes

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1450 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 19 gm/kg/19D-I

TOXIC EFFECTS :: Kidney, Ureter, Bladder - proteinuria Blood - changes in erythrocyte (RBC) count Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 52 gm/kg/30D-I

TOXIC EFFECTS :: Liver - liver function tests impaired Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 182 gm/kg/13W-I

TOXIC EFFECTS :: Liver - changes in liver weight Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 36400 mg/kg/1Y-I

TOXIC EFFECTS :: Liver - liver function tests impaired Kidney, Ureter, Bladder - urine volume increased Kidney, Ureter, Bladder - proteinuria

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 437 gm/kg/13W-I

TOXIC EFFECTS :: Liver - changes in liver weight Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 433 gm/kg/2Y-C

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, Bladder - Kidney tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 208 gm/kg/97W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors Liver - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 464 mg/kg

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Liver - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 264 gm/kg/99W-C

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors Liver - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 135 gm/kg/78W-I

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Liver - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 17280 mg/kg/9W-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors Kidney, Ureter, Bladder - Kidney tumors

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

REFERENCE :: GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 23(9),57,1979 *** REVIEWS *** ACGIH TLV-Not classifiable as a human carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 16,325,1978 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 16,325,1978 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,318,1987 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA;Carcinogen JAN 1993 OEL-BELGIUM;Carcinogen JAN 1993 OEL-FINLAND;Carcinogen JAN 1993 OEL-GERMANY;Carcinogen JAN 1993 OEL-SWEDEN;Carcinogen JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO N-PHENYL-beta-NAPHTHYLAMINE-air:CA lowest concentration REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80313 No. of Facilities: 751 (estimated) No. of Industries: 15 No. of Occupations: 32 No. of Employees: 16148 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80313 No. of Facilities: 33 (estimated) No. of Industries: 2 No. of Occupations: 4 No. of Employees: 1356 (estimated) No. of Female Employees: 41 (estimated)

N-苯基-2-萘胺安全信息

[ 符号 ]:

GHS07, GHS08, GHS09

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H317-H319-H351-H411

[ 警示性声明 ]:
P273-P280-P305 + P351 + P338

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
Xn,N

[ 风险声明 (欧洲) ]:
R36/38;R40;R43;R51/53

[ 安全声明 (欧洲) ]:
S22-S24/25-S61-S36/37-S26

[ 危险品运输编码 ]:
3077

[ WGK德国 ]:
2

[ RTECS号 ]:
QM4550000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

[ 海关编码 ]:
2921499090

N-苯基-2-萘胺合成路线

详细合成路线

N-苯基-2-萘胺上下游产品

N-苯基-2-萘胺上游产品

N-苯基-2-萘胺下游产品

N-苯基-2-萘胺制备

2-萘酚与苯胺在苯胺盐酸盐的催化下，于250℃进行缩合而得。将2-萘酚与苯加入缩合锅内熔化，投入苯胺盐酸盐进行缩合。反应结束后，用碳酸钠中和。蒸出过量的苯胺，再在真空下脱水干燥，经切片、打粉、包装即得防老剂丁。原料消耗(kg/t)2-萘酚（98.5%) 660 苯胺（99.2%) 425

将苯胺与萘酚按质量比为4.28∶6.63投入反应釜，加热熔融后，搅拌下继续加热至132℃以上，再加入0.09份的苯胺盐酸盐为催化剂，升温至170℃，反应4h。然后升温至250℃，继续加热反应，直到2-萘酚含量在1%以下，加纯碱中和苯胺盐酸盐至中性，进行真空蒸馏，回收苯胺，一直到馏出温度达到235～240℃时，取样分析釜液中苯胺的含量。当用新配制的10%的漂白粉饱和溶液滴加样品液不呈现紫色反应，即可停止蒸馏，趁热出料、干燥、粉碎即得成品。

N-苯基-2-萘胺海关

[ 海关编码 ]: 2921499090

[ 中文概述 ]:
2921499090 其他芳香单胺及衍生物及它们的盐. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2921499090 other aromatic monoamines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

N-苯基-2-萘胺文献

Unusual allergic contact dermatitis to aromatic amines.

Contact Dermatitis 17(1) , 42-4, (1987)

Quantitative analysis of aromatic amines in human urine by gas chromatography-mass spectrometry-selected-ion monitoring.

J. Chromatogr. A. 311(1) , 141-7, (1984)

Dephenylation of the rubber chemical N-phenyl-2-naphthylamine to carcinogenic 2-naphthylamine: a classical problem revisited.

Crit. Rev. Toxicol. 37(7) , 553-66, (2007)

N-phenyl-2-naphthylamine (PBNA) represents an example of a suspected carcinogen that is found negative in mutagenicity and clastogenicity testing as well as in long-term animal carcinogenicity bioassa...

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