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磷酸三(1,3-二氯-2-丙基)酯

磷酸三(1,3-二氯-2-丙基)酯用途

TDCPP 是三 (2,3-二溴丙基) 磷酸酯 (Tris) 的氯化类似物,它是在环境中检测到的最多的有机磷阻燃剂 (OPFR) 之一。

磷酸三(1,3-二氯-2-丙基)酯名称

[ CAS 号 ]:
13674-87-8

[ 中文名 ]:
磷酸三(1,3-二氯异丙基)酯

[ 英文名 ]:
TDCPP

[中文别名 ]:

[英文别名 ]:

Phosphoric Acid Tris(1,3-dichloro-2-propyl) Ester
Tris(1,3-dichloro-2-propanyl) phosphate
Tri(β,β'-dichloroisopropyl) phosphate
MFCD00083121
Tris(1,3-dichloropropan-2-yl) phosphate
TDCPP
Tris(1,3-dichloroisopropyl) phosphate
EINECS 237-159-2
Tris(1,3-dichloro-2-propyl) phosphate
1,3-Dichloro-2-propanol phosphate (3:1)

磷酸三(1,3-二氯-2-丙基)酯生物活性

[ 描述 ]:

TDCPP 是三 (2,3-二溴丙基) 磷酸酯 (Tris) 的氯化类似物,它是在环境中检测到的最多的有机磷阻燃剂 (OPFR) 之一。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 癌症

[体外研究]

在浓度>68μg/ mL之前,暴露于TDCPP不会显着影响细胞活力。在暴露于136μg/ mL TDCPP后,HCEC显示16％的细胞活力丧失。此外,TDCPP在暴露于≥272μg/ mL TDCPP后诱导活细胞急剧减少(87％)。基于细胞活力,使用非线性回归,TDCPP的LC50值为202μg/ mL。与对照相比,暴露于TDCPP的细胞表现出细胞凋亡的浓度依赖性增加。暴露于2μg/ mL TDCPP后,抗凋亡Bcl-2蛋白表达增加至1.4倍,在20μg/ mL时增加1.2倍,但与对照相比,在200μg/ mL时动态减少至0.4倍。在200μg/ mL TDCPP下,caspase-3活性增加至对照的2.1倍[1]。 TDCPP在较低浓度下抑制细胞生长(IC50为27μM),而细胞活力和毒性在较高浓度下受到影响(IC50分别为171μM和168μM)[2]。

[激酶实验]

根据制造商的指南，使用基于荧光素酶的ATP测定试剂盒，在含有0,2,20或200μg/ mL TDCPP的DMEM中生长的HCEC中测定细胞ATP含量。简而言之，暴露24小时后，用裂解缓冲液裂解HCEC。然后将裂解物在12,000g，4℃下离心5分钟。然后，将100μL上清液与100μLATP检测工作稀释液混合。通过荧光酶标仪[1]检查亮度。

[细胞实验]

为了检查TDCPP对细胞活力的影响，将HCEC以1×10 5个细胞/ mL的密度种植到96孔板（100μL/孔）中过夜。然后，将培养基更换为含有0.034,0.34,3.4,34,68,136,272或340μg/ mL TDCPP和溶剂载体（0.1％，v / v）的新鲜培养基，并培养24小时。根据制造商的说明，使用CCK-8细胞活力测定试剂盒检测细胞活力。暴露后，通过倒置显微镜观察并记录细胞形态[1]。

[参考文献]

[1]. Xiang P, et al. Effects of organophosphorus flame retardant TDCPP on normal human corneal epithelial cells: Implications for human health. Environ Pollut. 2017 Nov;230:22-30.

[2]. Killilea DW, et al. Flame retardant tris(1,3-dichloro-2-propyl)phosphate (TDCPP) toxicity is attenuated by N-acetylcysteine in human kidney cells. Toxicol Rep. 2017 May 17;4:260-264.

[相关活性小分子]

磷酸三(1,3-二氯-2-丙基)酯物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 沸点 ]:
457.4±40.0 °C at 760 mmHg

[ 熔点 ]:
-64°C

[ 分子式 ]:
C₉H₁₅Cl₆O₄P

[ 分子量 ]:
430.905

[ 闪点 ]:
377.7±35.0 °C

[ 精确质量 ]:
427.883911

[ PSA ]:
54.57000

[ LogP ]:
1.79

[ 外观性状 ]:
无色粘性液体

[ 蒸汽压 ]:
0.0±1.1 mmHg at 25°C

[ 折射率 ]:
1.497

[ 储存条件 ]:
室温

[ 水溶解性 ]:
<0.1 g/100 mL at 24 ºC

磷酸三(1,3-二氯-2-丙基)酯MSDS

详细MSDS(安全技术说明书)

磷酸三(1,3-二氯-2-丙基)酯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UB1473000

CAS REGISTRY NUMBER :: 13674-87-8

BEILSTEIN REFERENCE NO. :: 1715458

LAST UPDATED :: 199710

DATA ITEMS CITED :: 17

MOLECULAR FORMULA :: C9-H15-Cl6-O4-P

MOLECULAR WEIGHT :: 430.91

WISWESSER LINE NOTATION :: G1Y1GOPO&OY1G1GOY1G1G

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1850 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2250 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - tremor Behavioral - convulsions or effect on seizure threshold

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >23700 mg/kg

TOXIC EFFECTS :: Behavioral - irritability Gastrointestinal - hypermotility, diarrhea Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 15561 mg/kg/13W-C

TOXIC EFFECTS :: Gastrointestinal - tumors Kidney, Ureter, Bladder - tumors Blood - pigmented or nucleated red blood cells

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 16800 mg/kg/12W-I

TOXIC EFFECTS :: Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - chicken

DOSE/DURATION :: 24 gm/kg/5D-C

TOXIC EFFECTS :: Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 58400 mg/kg/2Y-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 3600 mg/kg

SEX/DURATION :: female 7-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Effects on Embryo or Fetus - fetal death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 3600 mg/kg

SEX/DURATION :: female 7-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetal death

MUTATION DATA

TYPE OF TEST :: Morphological transformation

TEST SYSTEM :: Rodent - hamster Embryo

DOSE/DURATION :: 20 umol/L

REFERENCE :: APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 56,20,1985 *** REVIEWS *** TOXICOLOGY REVIEW CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW. Volume(issue)/page/year: 17,101,1980

磷酸三(1,3-二氯-2-丙基)酯安全信息

[ 符号 ]:

GHS08, GHS09

[ 信号词 ]:
Warning

[ 危害声明 ]:
H351-H411

[ 警示性声明 ]:
P273-P281

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
Xn: Harmful;N: Dangerous for the environment;

[ 风险声明 (欧洲) ]:
R20/21/22

[ 安全声明 (欧洲) ]:
S26-S36/37/39-S61

[ 危险品运输编码 ]:
UN 3082 9/PG 3

[ RTECS号 ]:
UB1473000

[ 海关编码 ]:
2919900090

磷酸三(1,3-二氯-2-丙基)酯合成路线

详细合成路线

磷酸三(1,3-二氯-2-丙基)酯上下游产品

磷酸三(1,3-二氯-2-丙基)酯上游产品

磷酸三(1,3-二氯-2-丙基)酯下游产品

磷酸三(1,3-二氯-2-丙基)酯海关

[ 海关编码 ]: 2919900090

[ 中文概述 ]:
HS:2919900090 其他磷酸酯及其盐（包括乳磷酸盐）（包括它们的卤化，磺化，硝化和亚硝化衍生物）增值税率:17.0% 退税率:9.0% 监管条件:AB(入境货物通关单,出境货物通关单) 最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验 M.进口商品检验 N.出口商品检验

[ Summary ]:
2919900090 other phosphoric esters and their salts, including lactophosphates; their halogenated, sulphonated, nitrated or nitrosated derivatives。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:6.5%。general tariff:30.0%

磷酸三(1,3-二氯-2-丙基)酯文献

Haloalkylphosphorus hydrolases purified from Sphingomonas sp. strain TDK1 and Sphingobium sp. strain TCM1.

Appl. Environ. Microbiol. 80(18) , 5866-73, (2014)

Phosphotriesterases catalyze the first step of organophosphorus triester degradation. The bacterial phosphotriesterases purified and characterized to date hydrolyze mainly aryl dialkyl phosphates, suc...

Developmental exposure to the organophosphorus flame retardant tris(1,3-dichloro-2-propyl) phosphate: estrogenic activity, endocrine disruption and reproductive effects on zebrafish.

Aquat. Toxicol. 160 , 163-71, (2015)

Tris(1,3-dichloro-2-propyl) phosphate (TDCPP) is an organophosphate flame retardant that is detectable in the environment and biota, prompting concern over its risk to wildlife and human health. Our o...

Urinary metabolites of organophosphate flame retardants: temporal variability and correlations with house dust concentrations.

Environ. Health Perspect. 121 , 580-5, (2013)

A reduction in the use of polybrominated diphenyl ethers (PBDEs) because of human health concerns may result in an increased use of and human exposure to organophosphate flame retardants (OPFRs). Huma...

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