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双醋瑞因; 二乙酰大黄酸; 二乙酰二氢蒽羧酸

双醋瑞因; 二乙酰大黄酸; 二乙酰二氢蒽羧酸用途

Diacerein是白介素-1β抑制剂,是慢效的蒽醌类化合物。

双醋瑞因; 二乙酰大黄酸; 二乙酰二氢蒽羧酸名称

[ CAS 号 ]:
13739-02-1

[ 中文名 ]:
1,8-二乙酰基-3-羧基蒽醌

[ 英文名 ]:
Diacerein

[中文别名 ]:

[英文别名 ]:

DIACERHEIN
MFCD00468030
DIACETYL RHEIN
Fisiodar
4,5-diacetylrhein
Rhein Diacetate
SF 277
rhein,diacetate
Diacerein
artrodar

双醋瑞因; 二乙酰大黄酸; 二乙酰二氢蒽羧酸生物活性

[ 描述 ]:

Diacerein是白介素-1β抑制剂,是慢效的蒽醌类化合物。

[ 相关类别 ]:

信号通路 >> 免疫及炎症 >> 白细胞介素相关

研究领域 >> 炎症/免疫

天然产物 >> 醌类

[参考文献]

[1]. http://en.wikipedia.org/wiki/Diacerein

[相关活性小分子]

双醋瑞因; 二乙酰大黄酸; 二乙酰二氢蒽羧酸物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 沸点 ]:
631.5±55.0 °C at 760 mmHg

[ 熔点 ]:
217-2180C

[ 分子式 ]:
C₁₉H₁₂O₈

[ 分子量 ]:
368.294

[ 闪点 ]:
231.8±25.0 °C

[ 精确质量 ]:
368.053223

[ PSA ]:
124.04000

[ LogP ]:
1.99

[ 外观性状 ]:
固体;Light yellow to Amber to Dark green powder to crystal

[ 蒸汽压 ]:
0.0±1.9 mmHg at 25°C

[ 折射率 ]:
1.634

[ 储存条件 ]:
Refrigerator

双醋瑞因; 二乙酰大黄酸; 二乙酰二氢蒽羧酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CB8781000

CHEMICAL NAME :: 2-Anthroic acid, 9,10-dihydro-4,5-dihydroxy-9,10-dioxo-, diacetate

CAS REGISTRY NUMBER :: 13739-02-1

BEILSTEIN REFERENCE NO. :: 2184909

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C19-H12-O8

MOLECULAR WEIGHT :: 368.31

WISWESSER LINE NOTATION :: L C666 BV IVJ DOV1 FVQ NOV1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 7500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 4,445,1979

双醋瑞因; 二乙酰大黄酸; 二乙酰二氢蒽羧酸安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P305 + P351 + P338

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
36/37/38

[ 安全声明 (欧洲) ]:
26-36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
CB8781000

[ 海关编码 ]:
2918990090

双醋瑞因; 二乙酰大黄酸; 二乙酰二氢蒽羧酸合成路线

详细合成路线

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双醋瑞因; 二乙酰大黄酸; 二乙酰二氢蒽羧酸海关

[ 海关编码 ]: 2918990090

[ 中文概述 ]:
2918990090. 其他含其他附加含氧基羧酸（包括酸酐、酰卤化物、过氧化物和过氧酸及该税号的衍生物）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

双醋瑞因; 二乙酰大黄酸; 二乙酰二氢蒽羧酸文献

[Diacerein].

Ann. Ital. Med. Int. 1(2) , 172-4, (1986)

[Efficacy of diacerein on the symptoms and radiographic progression of osteoarthritis].

Presse Med. 31(39 Pt 2) , 4S13-5, (2002)

SYMPTOMATIC EFFECTS OF DIACEREIN: Data obtained from several clinical trials have demonstrated that relief of joint pain obtained with the interleukin-1 inhibitor diacerein is comparable with that obs...

Diacerein as a disease-modulating agent in osteoarthritis.

Curr. Rheumatol. Rep. 3(6) , 479-83, (2001)

This paper reviews the most recent clinical and experimental studies on diacerein, both of which are under investigation. Diacerein could be a disease-modulating agent in osteoarthritis because struct...

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