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大黄酸

大黄酸用途

Rhein 是一种蒽醌类化合物,具有抗炎、抗氧化、抗癌等作用。

大黄酸名称

[ CAS 号 ]:
478-43-3

[ 中文名 ]:
大黄酸

[ 英文名 ]:
Rhein

[中文别名 ]:

[英文别名 ]:

Rhein
1,8-dihydroxy-3-carboxy-9,10-anthraquinone
EINECS 207-521-4
Cassic acid
Rheic acid
Rhubarb Yellow
1,8-dihydroxyanthraquinone-3-carboxylic acid
1,8-dihydroxy-3-carboxyanthraquinone
MFCD00009618
Monorhein

大黄酸生物活性

[ 描述 ]:

Rhein 是一种蒽醌类化合物,具有抗炎、抗氧化、抗癌等作用。

[ 相关类别 ]:

信号通路 >> 自噬 >> 自噬

研究领域 >> 癌症

天然产物 >> 醌类

研究领域 >> 炎症/免疫

研究领域 >> 感染

[参考文献]

[1]. Xiaowen Chen, et al. Toll-like receptor 4 is involved in a protective effect of rhein on immunoglobulin A nephropathy. Indian J Pharmacol. 2015 Jan-Feb; 47(1): 27–33.

[2]. Hou ML, et al. The Drug-Drug Effects of Rhein on the Pharmacokinetics and Pharmacodynamics of Clozapine in Rat Brain Extracellular Fluid by In Vivo Microdialysis. J Pharmacol Exp Ther. 2015 Oct;355(1):125-34.

[3]. Yan-Xi Zhou, et al. Rhein: A Review of Pharmacological Activities. Evid Based Complement Alternat Med. 2015; 2015: 578107.

[相关活性小分子]

大黄酸物理化学性质

[ 密度 ]:
1.7±0.1 g/cm3

[ 沸点 ]:
597.8±50.0 °C at 760 mmHg

[ 熔点 ]:
≥300 °C(lit.)

[ 分子式 ]:
C₁₅H₈O₆

[ 分子量 ]:
284.220

[ 闪点 ]:
329.4±26.6 °C

[ 精确质量 ]:
284.032074

[ PSA ]:
111.90000

[ LogP ]:
4.58

[ 外观性状 ]:
为咖啡色针晶，升华后为黄色针晶。熔点 321-322℃，水溶性<0.1g/100mL

[ 蒸汽压 ]:
0.0±1.8 mmHg at 25°C

[ 折射率 ]:
1.761

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
<0.1 g/100 mL at 17 ºC

大黄酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CA9516000

CHEMICAL NAME :: 2-Anthracenecarboxylic acid, 9,10-dihydro-4,5-dihydroxy-9,10-dioxo-

CAS REGISTRY NUMBER :: 478-43-3

BEILSTEIN REFERENCE NO. :: 2222155

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C15-H8-O6

MOLECULAR WEIGHT :: 284.23

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PHTOEH Pharmacology and Toxicology (Copenhagen). (Munksgaard International Pub., POB 2148, DK-1016 Copenhagen K, Denmark) V.60- 1987- Volume(issue)/page/year: 61,153,1987

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >25 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PHTOEH Pharmacology and Toxicology (Copenhagen). (Munksgaard International Pub., POB 2148, DK-1016 Copenhagen K, Denmark) V.60- 1987- Volume(issue)/page/year: 61,153,1987

大黄酸安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R36/37/38:Irritating to eyes, respiratory system and skin .

[ 安全声明 (欧洲) ]:
S26-S37/39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
CA9516000

[ 海关编码 ]:
2918990090

大黄酸合成路线

详细合成路线

大黄酸上下游产品

大黄酸上游产品

大黄酸下游产品

大黄酸海关

[ 海关编码 ]: 2918990090

[ 中文概述 ]:
2918990090. 其他含其他附加含氧基羧酸（包括酸酐、酰卤化物、过氧化物和过氧酸及该税号的衍生物）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

大黄酸文献

Factors affecting formulation characteristics and stability of ascorbic acid in water-in-oil creams.

Int. J. Cosmet. Sci. 36(5) , 494-504, (2014)

The present investigation is based on the formulation of water-in-oil (w/o) cream preparations of ascorbic acid (AA) at pH 4-6 using different emollients and humectants.The preparations were stored in...

Binding of bis-(2-ethylhexyl) phthalate at the surface of hydrozincite nanocrystals: An example of organic molecules absorption onto nanocrystalline minerals.

J. Colloid. Interface Sci. 457 , 298-306, (2015)

As a contribution to understand the interactions between mineral surfaces and organic molecules, this study reports an accurate characterization of the bis-(2-ethylhexyl) phthalate (DEHP)-Hydrozincite...

Antioxidants in heat-processed koji and the production mechanisms.

Food Chem. 187 , 364-9, (2015)

We previously developed antioxidative heat-processed (HP)-koji via two-step heating (55 °C/2days → 75 °C/3 days) of white-koji. In this study, we isolated antioxidants in HP-koji and investigated thei...

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大黄酸