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芦荟大黄素

芦荟大黄素用途

芦荟大黄素(Aloe emodin)是从芦荟叶中提取出的羟基蒽醌,已被证明体外和体内抗肿瘤活性。

芦荟大黄素名称

[ CAS 号 ]:
481-72-1

[ 中文名 ]:
芦荟大黄素

[ 英文名 ]:
Aloeemodin

[中文别名 ]:

[英文别名 ]:

EINECS 207-571-7
Aloe emodin
MFCD00017373
1,8-Dihydroxy-3-(hydroxymethyl)anthracen-9,10-dion
1,8-Dihydroxy-3-(hydroxymethyl)anthraquinone
ALOE-EMODIN
Aloeemodin
3-Hydroxymethylchrysazine
EMODINE
Rhabarberone

芦荟大黄素生物活性

[ 描述 ]:

芦荟大黄素(Aloe emodin)是从芦荟叶中提取出的羟基蒽醌,已被证明体外和体内抗肿瘤活性。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 癌症

天然产物 >> 醌类

[参考文献]

[1]. Huang PH, et al. Emodin and Aloe-Emodin Suppress Breast Cancer Cell Proliferation through ER α Inhibition. Evid Based Complement Alternat Med. 2013;2013:376123.

[2]. Liu K, et al. Aloe-emodin suppresses prostate cancer by targeting the mTOR complex 2. Carcinogenesis. 2012 Jul;33(7):1406-11.

[3]. Li SW, et al. Antiviral activity of aloe-emodin against influenza A virus via galectin-3 up-regulation. Eur J Pharmacol. 2014 Sep 5;738:125-32.

[4]. Suboj P, et al. Aloe emodin inhibits colon cancer cell migration/angiogenesis by downregulating MMP-2/9, RhoB and VEGF via reduced DNA binding activity of NF-κB. Eur J Pharm Sci. 2012 Apr 11;45(5):581-91.

[相关活性小分子]

芦荟大黄素物理化学性质

[ 密度 ]:
1.6±0.1 g/cm3

[ 沸点 ]:
568.8±50.0 °C at 760 mmHg

[ 熔点 ]:
223-224°C

[ 分子式 ]:
C₁₅H₁₀O₅

[ 分子量 ]:
270.237

[ 闪点 ]:
311.9±26.6 °C

[ 精确质量 ]:
270.052826

[ PSA ]:
94.83000

[ LogP ]:
3.38

[ 外观性状 ]:
橙色针状结晶(由甲苯中)。易溶于热乙醇，在苯及乙醚中呈黄色，在氨水和硫酸中呈绯红色，属蒽醌类化合物，在酸性溶液中被还原则生成蒽酚及其互变异构体的蒽酮。熔点：223～224℃

[ 蒸汽压 ]:
0.0±1.6 mmHg at 25°C

[ 折射率 ]:
1.746

[ 储存条件 ]:
2-8°C

[ 稳定性 ]:
Hygroscopic

芦荟大黄素毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CB6712200

CHEMICAL NAME :: Anthraquinone, 1,8-dihydroxy-3-hydroxymethyl-

CAS REGISTRY NUMBER :: 481-72-1

BEILSTEIN REFERENCE NO. :: 2059062

LAST UPDATED :: 199612

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C15-H10-O5

MOLECULAR WEIGHT :: 270.25

WISWESSER LINE NOTATION :: L C666 BV IVJ DQ F1Q NQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation in mammalian somatic cells

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 10 mg/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 240,1,1990

芦荟大黄素安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R36/37/38:Irritating to eyes, respiratory system and skin .

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
CB6712200

芦荟大黄素合成路线

详细合成路线

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芦荟大黄素文献

Correlation between reduction potentials and inhibitions of Epstein-Barr virus activation by anthraquinone derivatives.

Bioorg. Med. Chem. Lett. 18 , 4106-9, (2008)

As a continuation of studies using natural and synthetic products as cancer chemopreventive agents, we used cyclic voltammetry to examine the reduction-oxidation potentials of methylated emodin deriva...

In vitro inhibition of Streptococcus mutans biofilm formation on hydroxyapatite by subinhibitory concentrations of anthraquinones.

Antimicrob. Agents Chemother. 51 , 1541-4, (2007)

We report that certain anthraquinones (AQs) reduce Streptococcus mutans biofilm formation on hydroxyapatite at concentrations below the MIC. Although AQs are known to generate reactive oxygen species,...

High-affinity, non-nucleotide-derived competitive antagonists of platelet P2Y12 receptors.

J. Med. Chem. 52 , 3784-93, (2009)

Anthraquinone derivatives related to the moderately potent, nonselective P2Y(12) receptor antagonist reactive blue 2 (6) have been synthesized and optimized with respect to P2Y(12) receptor affinity. ...

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