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硝普钠

硝普钠用途

硝普钠二水合物是一种血管舒张剂, 能促使NO释放于血液中。

硝普钠名称

[ CAS 号 ]:
13755-38-9

[ 中文名 ]:
硝普钠二水合物

[ 英文名 ]:
Sodium nitroprusside dihydrate

[中文别名 ]:

[英文别名 ]:

Sodium nitroprusside
EINECS 238-373-9
Nitroprusside sodium
Sodium nitroferricyanide(III) dihydrate
Sodium nitroferricyanide dihydrate
SODIUM NITROPRUSSIDE DIHYDRATE
MFCD00149192
sodium pentacyanidonitrosylferrate(III) dihydrate
Nipridedihydrate
Sodium pentacyanonitrosylferrate dihydrate

硝普钠生物活性

[ 描述 ]:

硝普钠二水合物是一种血管舒张剂, 能促使NO释放于血液中。

[ 相关类别 ]:

信号通路 >> 自噬 >> 自噬

研究领域 >> 心血管疾病

[参考文献]

[1]. Wink, D.A., et al., The effect of various nitric oxide-donor agents on hydrogen peroxide-mediated toxicity: a direct correlation between nitric oxide formation and protection. Arch Biochem Biophys, 1996. 331(2): p. 241-8.

[2]. Garg, U.C. and A. Hassid, Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells. J Clin Invest, 1989. 83(5): p. 1774-7.

[3]. Namazi, H., Sodium nitroprusside as a nitric oxide donor in a rat intestinal ischemia reperfusion model: a novel molecular mechanism. Clinics (Sao Paulo), 2008. 63(3): p. 405.

[相关活性小分子]

硝普钠物理化学性质

[ 密度 ]:
1.72

[ 分子式 ]:
C₅H₄FeN₆Na₂O₃

[ 分子量 ]:
297.948

[ 精确质量 ]:
297.948975

[ PSA ]:
166.84000

[ LogP ]:
0.16990

[ 外观性状 ]:
亮红色

[ 储存条件 ]:
Store at RT.

[ 水溶解性 ]:
400g/l (slow decomposition)

硝普钠MSDS

详细MSDS(安全技术说明书)

硝普钠毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LJ8925000

CHEMICAL NAME :: Ferrate(2-), pentacyanonitrosyl-, disodium, dihydrate

CAS REGISTRY NUMBER :: 13755-38-9

LAST UPDATED :: 199707

DATA ITEMS CITED :: 17

MOLECULAR FORMULA :: C5-Fe-N6-O.2Na.2H2-O

MOLECULAR WEIGHT :: 297.98

WISWESSER LINE NOTATION :: NA2 FE-CN5-NO &QH 2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Human - child

DOSE/DURATION :: 11700 ug/kg/60H-I

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - effect, not otherwise specified

REFERENCE :: CPEDAM Clinical Pediatrics (Philadelphia). (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1962- Volume(issue)/page/year: 31,380,1992

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 20 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- Volume(issue)/page/year: 22,883,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 7 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AANFAE Annales de l'Anesthesiologie Francaise. (Paris, France) V.1-22, 1960-81. Volume(issue)/page/year: 18(2),153,1977

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 9300 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 29,1092,1979

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 9 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AANFAE Annales de l'Anesthesiologie Francaise. (Paris, France) V.1-22, 1960-81. Volume(issue)/page/year: 18(2),153,1977

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 9500 ug/kg

TOXIC EFFECTS :: Behavioral - excitement Lungs, Thorax, or Respiration - respiratory stimulation Gastrointestinal - nausea or vomiting

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 35,480,1929

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 6 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AANFAE Annales de l'Anesthesiologie Francaise. (Paris, France) V.1-22, 1960-81. Volume(issue)/page/year: 18(2),153,1977

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 80 mg/kg

TOXIC EFFECTS :: Behavioral - excitement Lungs, Thorax, or Respiration - respiratory stimulation Gastrointestinal - nausea or vomiting

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 35,480,1929

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 1 mg/kg

TOXIC EFFECTS :: Behavioral - excitement Lungs, Thorax, or Respiration - respiratory stimulation Gastrointestinal - nausea or vomiting

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 35,480,1929

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Behavioral - excitement Lungs, Thorax, or Respiration - respiratory stimulation Gastrointestinal - nausea or vomiting

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 35,480,1929

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 1 mg/kg

TOXIC EFFECTS :: Behavioral - excitement Lungs, Thorax, or Respiration - respiratory stimulation Gastrointestinal - nausea or vomiting

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 35,480,1929

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 40 mg/kg

TOXIC EFFECTS :: Behavioral - excitement Lungs, Thorax, or Respiration - respiratory stimulation Gastrointestinal - nausea or vomiting

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 35,480,1929

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 4800 ug/kg

TOXIC EFFECTS :: Behavioral - excitement Lungs, Thorax, or Respiration - respiratory stimulation Gastrointestinal - nausea or vomiting

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 35,480,1929

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1800 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 29,1092,1979

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Bird - pigeon

DOSE/DURATION :: 10 mg/kg

TOXIC EFFECTS :: Behavioral - excitement Lungs, Thorax, or Respiration - respiratory stimulation Gastrointestinal - nausea or vomiting

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 35,480,1929

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Amphibian - frog

DOSE/DURATION :: 40 mg/kg

TOXIC EFFECTS :: Behavioral - excitement Lungs, Thorax, or Respiration - respiratory stimulation Gastrointestinal - nausea or vomiting

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 35,480,1929 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X6152 No. of Facilities: 76 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 1925 (estimated) No. of Female Employees: 1358 (estimated)

硝普钠安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301

[ 警示性声明 ]:
P301 + P310

[ 个人防护装备 ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T: Toxic;

[ 风险声明 (欧洲) ]:
R25

[ 安全声明 (欧洲) ]:
45-36/37/39-22

[ 危险品运输编码 ]:
UN 3288 6

[ WGK德国 ]:
3

[ RTECS号 ]:
LJ8925000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1

[ 海关编码 ]:
2837199090

硝普钠制备

1.在加热条件下，用水溶解三水合亚铁氰化钾，配制成30%的亚铁氰化钾溶液，并在搅拌下加入超过理论量一倍的亚硝酸钠，加热至85℃，然后缓慢滴加用相对密度为1.84的浓硫酸配制成的21%的稀硫酸，控制加酸速度，以保证反应物温度不超过85～90℃。加酸完毕后，再加入少量相同浓度的稀
硫酸，之后，加热至100℃，保温1～2h，检验溶液中[ Fe(CN)₆ ]^4-和[ Fe(CN)₆ ]^3-离子，若存在，则需再加入少量亚硝酸钠并加热直至溶液中不含[ Fe(CN)₆ ]^4-和[ Fe(CN)₆ ]^3-离子：

反应结束后，滤去不溶物，于搅拌下加入80℃的20%的硫酸铜水溶液：

静置后，分去上层清液，用25～30℃的水洗涤沉淀至洗涤水中SO₄^2- 离子合格。所得的亚硝基铁氰化铜用适量碳酸氢钠浓溶液进行分解：

静置，滤出液体后，用水洗涤沉淀，洗液并入滤液，加入少量醋酸酸化，然后
加热蒸发至原体积的1／2，加入少量醋酸钡，使SO₄^2- 离子沉淀完全，过滤，所得滤液加热蒸发至出现结晶薄膜，冷却结晶，甩干后用热水重结晶，最后于40℃以下干燥，即得成品。

硝普钠海关

[ 海关编码 ]: 2837199090

硝普钠文献

In vivo imaging of reactive oxygen species in mouse brain by using [3H]hydromethidine as a potential radical trapping radiotracer.

J. Cereb. Blood Flow Metab. 34(12) , 1907-13, (2014)

To assess reactive oxygen species (ROS) production by detecting the fluorescent oxidation product, hydroethidine has been used extensively. The present study was undertaken to evaluate the potential o...

Involvement of H1 and H2 receptors and soluble guanylate cyclase in histamine-induced relaxation of rat mesenteric collecting lymphatics.

Microcirculation 21(7) , 593-605, (2014)

This study investigated the roles of the H1 and H2 histamine receptors, NO synthase, and sGC cyclase in histamine-induced modulation of rat mesenteric collecting lymphatic pumping.Isolated rat mesente...

Propofol protects against nitrosative stress-induced apoptotic insults to cerebrovascular endothelial cells via an intrinsic mitochondrial mechanism.

Surgery 154(1) , 58-68, (2013)

Cerebrovascular endothelial cells (CECs), major component cells of the blood-brain barrier, can be injured by oxidative stress. Propofol can protect cells from oxidative injury. The aim of this study ...

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硝普钠