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盐酸齐拉西酮

盐酸齐拉西酮用途

Ziprasidone(CP88059)是5-HT和多巴胺受体拮抗剂,有抗精神病活性。

盐酸齐拉西酮名称

[ CAS 号 ]:
138982-67-9

[ 中文名 ]:
齐拉西酮盐酸盐一水合物

[ 英文名 ]:
Ziprasidone Hydrochloride Monohydrate

[中文别名 ]:

[英文别名 ]:

cp 88059-1
Ziprasidone
Ziprasidone Hydrochloride Monohydrate
Ziprasidone hydrochloride
MFCD06795476
Ziprasidone (hydrochloride monohydrate)

盐酸齐拉西酮生物活性

[ 描述 ]:

Ziprasidone(CP88059)是5-HT和多巴胺受体拮抗剂,有抗精神病活性。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 5-HT受体

信号通路 >> 神经信号通路 >> 5-HT受体

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 多巴胺受体

信号通路 >> 神经信号通路 >> 多巴胺受体

研究领域 >> 神经疾病

[参考文献]

[1]. Papakostas GI, Petersen TJ, Nierenberg AA, et al. Ziprasidone augmentation of selective serotonin reuptake inhibitors (SSRIs) for SSRI-resistant major depressive disorder. The Journal of Clinical Psychiatry. 2004, 65(2):217-221.

[2]. Paul E. Keck, Marcio Versiani, Steven Potkin, et al. Ziprasidone in the Treatment of Acute Bipolar Mania: A Three-Week, Placebo-Controlled, Double-Blind, Randomized Trial. Am J Psychiatry 2003;160:741-748.

[3]. Glen L. Stimmel, Mary A. Gutierrez, Vivian Lee. Ziprasidone: An atypical antipsychotic drug for the treatment of schizophrenia. Clinical Therapeutics, 2002, 24(1):21-37.

[4]. Anne W Schmidt, Lorraine A Lebel, Harry R Howard Jr. et al. Ziprasidone: a novel antipsychotic agent with a unique human receptor binding profile. European Journal of Pharmacology. 2001,425(3):197-201.

[5]. Ziprasidone

[相关活性小分子]

盐酸齐拉西酮物理化学性质

[ 沸点 ]:
554.8ºC at 760 mmHg

[ 熔点 ]:
300°C

[ 分子式 ]:
C₂₁H₂₄Cl₂N₄O₂S

[ 分子量 ]:
467.412

[ 精确质量 ]:
466.099701

[ PSA ]:
85.94000

[ LogP ]:
4.68760

[ 外观性状 ]:
固体;White to Orange to Green powder to crystal

[ 蒸汽压 ]:
2.38E-12mmHg at 25°C

[ 储存条件 ]:
Room temp

盐酸齐拉西酮MSDS

详细MSDS(安全技术说明书)

盐酸齐拉西酮安全信息

[ 符号 ]:

GHS07, GHS08

[ 信号词 ]:
Warning

[ 危害声明 ]:
H317-H373

[ 警示性声明 ]:
P260-P280

[ 靶器官 ]:
Central nervous system, Liver

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R36/37/38:Irritating to eyes, respiratory system and skin .

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
2934999090

盐酸齐拉西酮海关

[ 海关编码 ]: 2934999090

[ 中文概述 ]:
2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

盐酸齐拉西酮文献

Gingival pain: an unusual side effect of ziprasidone.

BMJ Case Rep. 2013 , doi:10.1136/bcr-2012-007577, (2013)

The patient is a 52-year-old man with schizophrenia who developed severe, unremitting gingival pain after his ziprasidone dosage was increased from 80 to 120 mg. His physical examination and laborator...

A thorough QTc study of 3 doses of iloperidone including metabolic inhibition via CYP2D6 and/or CYP3A4 and a comparison to quetiapine and ziprasidone.

J. Clin. Psychopharmacol. 33(1) , 3-10, (2013)

The potential for iloperidone, a D2/5-HT2A antipsychotic, to affect the heart rate-corrected QT interval (QTc) was assessed in the absence and presence of metabolic inhibitors in a randomized, open-la...

Association between second-generation antipsychotics and changes in body mass index in adolescents.

J. Adolesc. Health 52(3) , 336-43, (2013)

To assess the association of second-generation antipsychotics (SGAs) with changes in body mass index (BMI) among adolescents compared with a matched untreated comparison group.A retrospective cohort s...

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