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PEPA

PEPA用途

PEPA是AMPAR变构调节剂,能结合GluA2o/GluA3o的LBDs结构域。

PEPA名称

[ CAS 号 ]:
141286-78-4

[ 中文名 ]:
PEPA

[ 英文名 ]:
PEPA

[英文别名 ]:

PEPA

PEPA生物活性

[ 描述 ]:

PEPA是AMPAR变构调节剂,能结合GluA2o/GluA3o的LBDs结构域。

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> iGluR

信号通路 >> 神经信号通路 >> iGluR

研究领域 >> 神经疾病

[参考文献]

[1]. Sekiguchi M, et al. Pharmacological detection of AMPA receptor heterogeneity by use of two allosteric potentiators in rat hippocampal cultures. Br J Pharmacol. 1998 Apr;123(7):1294-303.

[2]. Ahmed AH, et al. Molecular mechanism of flop selectivity and subsite recognition for an AMPA receptor allosteric modulator: structures of GluA2 and GluA3 in complexes with PEPA. Biochemistry. 2010 Apr 6;49(13):2843-50.

[3]. Yamada D, et al. Facilitating actions of an AMPA receptor potentiator upon extinction of contextually conditioned fear response in stressed mice. Neurosci Lett. 2011 Jan 25;488(3):242-6.

[4]. Zhang QG, et al. Positive modulation of AMPA receptors prevents downregulation of GluR2 expression and activates the Lyn-ERK1/2-CREB signaling in rat brain ischemia. Hippocampus. 2010 Jan;20(1):65-77.

[相关活性小分子]

PEPA物理化学性质

[ 分子式 ]:
C₁₆H₁₆F₂N₂O₄S₂

[ 分子量 ]:
402.43600

[ 精确质量 ]:
402.05200

[ PSA ]:
132.17000

[ LogP ]:
4.07150

[ 储存条件 ]:
2-8℃

PEPAMSDS

详细MSDS(安全技术说明书)

PEPA安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
2935009090

PEPA海关

[ 海关编码 ]: 2935009090

[ 中文概述 ]:
2935009090 其他磺（酰）胺. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:35.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

PEPA文献

Positive modulation of AMPA receptors prevents downregulation of GluR2 expression and activates the Lyn-ERK1/2-CREB signaling in rat brain ischemia.

Psychopharmacology 20 , 65-77, (2010)

alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs) are responsible for excitotoxicity induced by ischemic injury in hippocampal CA1 neurons, whereas the molecular mechanisms r...

Activation of AMPA receptor in the infralimbic cortex facilitates extinction and attenuates the heroin-seeking behavior in rats.

Neurosci. Lett. 612 , 126-31, (2016)

Infralimbic cortex (IL) is proposed to suppress cocaine seeking after extinction, but whether the IL regulates the extinction and reinstatement of heroin-seeking behavior is unknown. To address this i...

The rostromedial tegmental nucleus modulates behavioral inhibition following cocaine self-administration in rats.

Neuropsychopharmacology 40(4) , 861-73, (2015)

Recent findings suggest that the mesolimbic dopamine neurons, known to promote cocaine-seeking behavior, are strongly inhibited by a newly characterized region of the midbrain known as the rostromedia...

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