软骨藻酸

软骨藻酸用途

Domoic acid ((-)-Domoic acid; L-Domoic acid) 是一种兴奋性神经递质,从海洋植物 Nitzschia pungens 中分离出来。Domoic acid 通过激活海藻酸酯受体 (kainate receptor) 产生神经毒性作用。

软骨藻酸名称

[ CAS 号 ]:
14277-97-5

[ 中文名 ]:
软骨藻酸

[ 英文名 ]:
Domoic acid

[中文别名 ]:

二甲乙二烯咯三酸

[英文别名 ]:

Domoic acid
MFCD00040640
L-Domoic acid

软骨藻酸生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 神经信号通路 >> iGluR

研究领域 >> 神经疾病

信号通路 >> 跨膜转运 >> iGluR

[参考文献]

[1]. T M Perl, et al. An outbreak of toxic encephalopathy caused by eating mussels contaminated with domoic acid. N Engl J Med. 1990 Jun 21;322(25):1775-80.

[2]. G Debonnel, et al. Domoic acid, the alleged "mussel toxin," might produce its neurotoxic effect through kainate receptor activation: an electrophysiological study in the dorsal hippocampus. Can J Physiol Pharmacol. 1989 Jan;67(1):29-33.

软骨藻酸物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
607.2±55.0 °C at 760 mmHg

[ 熔点 ]:
228ºC

[ 分子式 ]:
C₁₅H₂₁NO₆

[ 分子量 ]:
311.330

[ 闪点 ]:
321.0±31.5 °C

[ 精确质量 ]:
311.136902

[ PSA ]:
123.93000

[ LogP ]:
0.61

[ 外观性状 ]:
白色至灰白色固体

[ 蒸汽压 ]:
0.0±3.7 mmHg at 25°C

[ 折射率 ]:
1.545

软骨藻酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UX9665100

CHEMICAL NAME :: 3-Pyrrolidineacetic acid, 2-carboxy-4-(5-carboxy-1-methyl-1,3-hexadienyl)-, (2S-(2-alpha,3- beta,4-beta(1Z,3E,5S*)))-

CAS REGISTRY NUMBER :: 14277-97-5

LAST UPDATED :: 199706

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C15-H21-N-O6

MOLECULAR WEIGHT :: 311.37

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3600 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.1- 1962- Volume(issue)/page/year: 28,501,1990 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 320 mg/kg/9W-I

TOXIC EFFECTS :: Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 34,525,1996

软骨藻酸安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H312-H332

[ 警示性声明 ]:
P280

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
R20/21/22

[ 危险品运输编码 ]:
UX9665100

[ RTECS号 ]:
UX9665100

软骨藻酸合成路线

详细合成路线

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软骨藻酸文献

Metal-organic framework UiO-66 modified magnetite@silica core-shell magnetic microspheres for magnetic solid-phase extraction of domoic acid from shellfish samples.

J. Chromatogr. A. 1400 , 10-8, (2015)

Fe3O4@SiO2@UiO-66 core-shell magnetic microspheres were synthesized and characterized by transmission electron microscopy, scanning electron microscopy, X-ray diffraction, Fourier transform infrared s...

The prostaglandin EP1 receptor potentiates kainate receptor activation via a protein kinase C pathway and exacerbates status epilepticus.

Neurobiol. Dis. 70 , 74-89, (2014)

Prostaglandin E2 (PGE2) regulates membrane excitability, synaptic transmission, plasticity, and neuronal survival. The consequences of PGE2 release following seizures has been the subject of much stud...

Ursolic acid improves domoic acid-induced cognitive deficits in mice.

Toxicol. Appl. Pharmacol. 271(2) , 127-36, (2013)

Our previous findings suggest that mitochondrial dysfunction is the mechanism underlying cognitive deficits induced by domoic acid (DA). Ursolic acid (UA), a natural triterpenoid compound, possesses m...

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