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四乙二醇二甲醚

四乙二醇二甲醚用途

Me-PEG4-Me 是一种 PROTAC linker,属于 PEG 类。可用于合成 PROTAC 分子。

四乙二醇二甲醚名称

[ CAS 号 ]:
143-24-8

[ 中文名 ]:
四乙二醇二甲醚

[ 英文名 ]:
Me-PEG4-Me

[中文别名 ]:

[英文别名 ]:

tetraglyme
Dimethyltetraglycol
Bis[2-(2-methoxyethoxy)ethyl] ether
MFCD00008505
2,5,8,11,14-Pentaoxapentadecane
EINECS 205-594-7
Dimethoxytetraethylene glycol
Tetraethylene glycol dimethyl ether

四乙二醇二甲醚生物活性

[ 描述 ]:

Me-PEG4-Me 是一种 PROTAC linker,属于 PEG 类。可用于合成 PROTAC 分子。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 蛋白裂解靶向嵌合体 >> PROTAC Linker

[ 靶点 ]

PEGs

[体外研究]

PROTACs包含两个不同的配体,通过连接体连接；一个是E3泛素连接酶的配体,另一个是靶蛋白的配体。PROTACs利用细胞内泛素-蛋白酶体系统选择性降解靶蛋白[1]。

[参考文献]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

四乙二醇二甲醚物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
275.3±0.0 °C at 760 mmHg

[ 熔点 ]:
−30 °C(lit.)

[ 分子式 ]:
C₁₀H₂₂O₅

[ 分子量 ]:
222.279

[ 闪点 ]:
140.6±0.0 °C

[ 精确质量 ]:
222.146729

[ PSA ]:
46.15000

[ LogP ]:
-1.51

[ 外观性状 ]:
透明液体

[ 蒸汽密度 ]:
7.7 (vs air)

[ 蒸汽压 ]:
0.0±0.5 mmHg at 25°C

[ 折射率 ]:
1.421

[ 储存条件 ]:
存放于惰性气体之中;避免空气,湿气 (吸湿)

[ 水溶解性 ]:
可溶

四乙二醇二甲醚MSDS

四乙二醇二甲醚毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SB0400000

CHEMICAL NAME :: 2,5,8,11,14-Pentaoxapentadecane

CAS REGISTRY NUMBER :: 143-24-8

BEILSTEIN REFERENCE NO. :: 1760005

LAST UPDATED :: 199710

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C10-H22-O5

MOLECULAR WEIGHT :: 222.32

WISWESSER LINE NOTATION :: 1O2O2O2O2O1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918- Volume(issue)/page/year: 29,1363,1946 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5140 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Gastrointestinal - other changes Kidney, Ureter, Bladder - other changes

REFERENCE :: JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 23,259,1941 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 1000 ppm/7H

SEX/DURATION :: male 5 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females) Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 70,303,1983

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 1000 ppm/7H

SEX/DURATION :: male 5 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 70,303,1983

四乙二醇二甲醚安全信息

[ 符号 ]:

GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H360Df

[ 警示性声明 ]:
P201-P308 + P313

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
Xi:Irritant;

[ 风险声明 (欧洲) ]:
R19;R43

[ 安全声明 (欧洲) ]:
S36-S24

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
1

[ RTECS号 ]:
SB0400000

[ 海关编码 ]:
2942000000

四乙二醇二甲醚合成路线

四乙二醇二甲醚制备

1.主要采用二乙醇单甲醚与氯化亚砜合成法。将二乙醇单甲醚用氯化亚砜氯化,再另将二乙醇单甲醚制成醇钠,然后将两者进行缩合反应,最后经过滤、真空蒸馏而得。

四乙二醇二甲醚海关

[ 海关编码 ]: 2901100000

[ 中文概述 ]:
2901100000 饱和无环烃。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:2.0%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 用作气体燃料的应报明包装容器容积, 散装货物应报明

[ Summary ]:
2901100000 saturated acyclic hydrocarbons。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:2.0%。General tariff:30.0%

四乙二醇二甲醚文献

Radical Cationic Pathway for the Decay of Ionized Glyme Molecules in Liquid Solution.

J. Phys. Chem. B 119 , 14472-8, (2015)

Chemical stability of primary radical cations (RCs) generated in irradiated matter determines substantially the radiation resistance of organic materials. Transformations of the RCs of the glyme molec...

Development of bipolar all-solid-state lithium battery based on quasi-solid-state electrolyte containing tetraglyme-LiTFSA equimolar complex.

Sci. Rep. 5 , 8869, (2015)

The development of high energy-density lithium-ion secondary batteries as storage batteries in vehicles is attracting increasing attention. In this study, high-voltage bipolar stacked batteries with a...

Mechanism and Kinetics of Li2S Precipitation in Lithium-Sulfur Batteries.

Adv. Mater. 27 , 5203-9, (2015)

The kinetics of Li2 S electrodeposition onto carbon in lithium-sulfur batteries are characterized. Electrodeposition is found to be dominated by a 2D nucleation and growth process with rate constants ...

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