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乙二醇二甲醚

乙二醇二甲醚用途

【用途一】
主要用于聚合物化学、电化学、硼化学工艺领域，还用作树脂、硝化纤维素等的溶剂
【用途二】
主要用作溶剂和有机合成中间体
【用途三】
用作溶剂和有机合成中间体。

乙二醇二甲醚名称

[ CAS 号 ]:
110-71-4

[ 中文名 ]:
乙二醇二甲醚

[ 英文名 ]:
1,2-dimethoxyethane

[中文别名 ]:

1,2-二甲氧基乙烷

[英文别名 ]:

1,2-dimethyloxyethane
Ethylene glycol dimethyl ether
MFCD00008502
1,2-Dimethoxydiphenid
Ethylene glycol dimethyl ether,stabilized with BHT
1,2-methoxyethane
dimethyl cellosolve
1,2-Dimethoxyethane
EINECS 203-794-9
1,2-dimethoxy-ethane

乙二醇二甲醚物理化学性质

[ 密度 ]:
0.8±0.1 g/cm3

[ 沸点 ]:
84-86 ºC

[ 熔点 ]:
-69 °C

[ 分子式 ]:
C₄H₁₀O₂

[ 分子量 ]:
90.121

[ 闪点 ]:
6 ºC

[ 精确质量 ]:
90.068077

[ PSA ]:
18.46000

[ LogP ]:
-0.44

[ 外观性状 ]:
水白色液体

[ 蒸汽密度 ]:
3.1 (20 °C, vs air)

[ 蒸汽压 ]:
80.6±0.1 mmHg at 25°C

[ 折射率 ]:
1.367

[ 储存条件 ]:
库房通风低温干燥,与氧化剂分开存放

[ 稳定性 ]:
Stable, but explosive peroxides may form on exposure to air. Test for the presence of peroxides before heating. Avoid heat, light, air. Highly flammable. Store under inert gas.

[ 水溶解性 ]:
Miscible

乙二醇二甲醚MSDS

乙二醇二甲醚毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KI1451000

CHEMICAL NAME :: Ethane, 1,2-dimethoxy-

CAS REGISTRY NUMBER :: 110-71-4

BEILSTEIN REFERENCE NO. :: 1209237

LAST UPDATED :: 199806

DATA ITEMS CITED :: 20

MOLECULAR FORMULA :: C4-H10-O2

MOLECULAR WEIGHT :: 90.14

WISWESSER LINE NOTATION :: 1O2O1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0539769

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 63 gm/m3/6H

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - irritability

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0571323

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0571323

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0571323

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0571323

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0539769 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4000 ppm/4H/2W-I

TOXIC EFFECTS :: Behavioral - changes in psychophysiological tests Lungs, Thorax, or Respiration - other changes Related to Chronic Data - death

REFERENCE :: AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 25,369,1964 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 660 mg/kg

SEX/DURATION :: female 8-18 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Specific Developmental Abnormalities - homeostasis

REFERENCE :: REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 5,157,1991

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 660 mg/kg

SEX/DURATION :: female 8-18 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - stillbirth Reproductive - Effects on Newborn - live birth index (measured after birth) Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive)

REFERENCE :: REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 5,157,1991

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 660 mg/kg

SEX/DURATION :: female 8-18 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)

REFERENCE :: REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987- Volume(issue)/page/year: 5,157,1991

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1960 mg/kg

SEX/DURATION :: female 7-10 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetal death Reproductive - Specific Developmental Abnormalities - other developmental abnormalities

REFERENCE :: NISFAY Nippon Sanka Fujinka Gakkai Zasshi. Journal of the Japan Society of Obstetrics and Gynecology. (Nippon Sanka Fujinka Gakkai Zasshi, Hoken Kaikan Bekkan, 1-1 Sadohara-cho, Ichigaya, Shijuku-ku, Tokyo 162, Japan) V.1- 1949- Volume(issue)/page/year: 32,113,1980

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1400 mg/kg

SEX/DURATION :: female 7-10 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - Central Nervous System

REFERENCE :: NISFAY Nippon Sanka Fujinka Gakkai Zasshi. Journal of the Japan Society of Obstetrics and Gynecology. (Nippon Sanka Fujinka Gakkai Zasshi, Hoken Kaikan Bekkan, 1-1 Sadohara-cho, Ichigaya, Shijuku-ku, Tokyo 162, Japan) V.1- 1949- Volume(issue)/page/year: 32,113,1980

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 361 mg/kg

SEX/DURATION :: female 11 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

REFERENCE :: TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 35,321,1987

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 16 gm/kg

SEX/DURATION :: female 7-14 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

REFERENCE :: EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972- Volume(issue)/page/year: 57,141,1984 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 10 mg/m3 JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83728 No. of Facilities: 68 (estimated) No. of Industries: 3 No. of Occupations: 2 No. of Employees: 265 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83728 No. of Facilities: 94 (estimated) No. of Industries: 4 No. of Occupations: 7 No. of Employees: 3319 (estimated) No. of Female Employees: 1003 (estimated)

乙二醇二甲醚安全信息

[ 符号 ]:

GHS02, GHS07, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H315-H360FD

[ 补充危害声明 ]:
May form explosive peroxides.

[ 警示性声明 ]:
P201-P210-P308 + P313

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
F:Flammable

[ 风险声明 (欧洲) ]:
R11;R19;R20;R60;R61

[ 安全声明 (欧洲) ]:
S53-S45

[ 危险品运输编码 ]:
UN 2252 3/PG 2

[ WGK德国 ]:
1

[ RTECS号 ]:
KI1451000

[ 包装等级 ]:
II

[ 危险类别 ]:
3

[ 海关编码 ]:
29091900

乙二醇二甲醚合成路线

乙二醇二甲醚上下游产品

乙二醇二甲醚上游产品

乙二醇二甲醚下游产品

乙二醇二甲醚制备

1.由乙二醇单甲醚与金属钠；氯甲烷反应而得。将乙二醇单甲醚与金属钠一起回流，直至金属钠完全反应，降温至45℃，通入氯甲烷。反应毕，进行分馏，收集84-85.5℃馏分，即得成品。

精制方法：过氧化物的检验方法与乙醚相同。过氧化物可用氯化亚锡一起回流或通过活性氧化铝除去。然后添加少量的金属钠以除微量的水分。其他精制方法有先用钠丝干燥，在氮气流下加氢化铝锂蒸馏。也可以先用无水氯化钙干燥数天，过滤、加金属钠蒸馏，或加氢化铝锂保存，用前蒸馏。

2.边搅拌边将金属钠于60℃下分次少量加到乙二醇单甲醚中，控制温度在78～81℃，金属钠加完后，降温至45℃，然后通入氯甲烷。反应式为：

反应结束后，蒸馏，收集84.5～85.5℃馏分，即得乙二醇二甲醚。

3.用钠丝干燥后，在氮气存在下加氢化铝锂蒸馏，也可用无水氯化钙干燥数天后，滤去氯化钙，再加金属钠蒸馏，或加入氢化铝锂后放置，现用现蒸馏。

乙二醇二甲醚海关

[ 海关编码 ]: 2909199090

[ 中文概述 ]:
2909199090. 其他无环醚及其卤化衍生物（包括磺化，硝化或亚硝化衍生物）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:5.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2909199090. other acyclic ethers and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%

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