Secalciferol-d6

Secalciferol-d6用途

Secalciferol-d6((24R)-24,25-二羟维生素D3-d6)是氘标记的Secalciferol。Secalciferol是维生素D的代谢物,维生素D可能是一种抗炎类固醇,参与骨骨化[1][2]。

Secalciferol-d6名称

[ CAS 号 ]:
1440957-55-0

[ 英文名 ]:
Secalciferol-d6

Secalciferol-d6生物活性

[ 描述 ]:

Secalciferol-d6((24R)-24,25-二羟维生素D3-d6)是氘标记的Secalciferol。Secalciferol是维生素D的代谢物,维生素D可能是一种抗炎类固醇,参与骨骨化[1][2]。

[ 相关类别 ]:

信号通路 >> 维生素 D 相关 >> VD/VDR

研究领域 >> 炎症/免疫

[体外研究]

氢、碳和其他元素的稳定重同位素已被纳入药物分子,主要作为药物开发过程中定量的示踪剂。氘化因其可能影响药物的药代动力学和代谢特征而受到关注[1]。

[参考文献]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Yamamoto T, Ozono K, Shima M, et al. 24R,25-dihydroxyvitamin D3 increases cyclic GMP contents, leading to an enhancement of osteocalcin synthesis by 1,25-dihydroxyvitamin D3 in cultured human osteoblastic cells. Exp Cell Res. 1998 Oct 10;244(1):71-6.

[3]. Sakaki T, Sawada N, Takeyama K, et al. Enzymatic properties of mouse 25-hydroxyvitamin D3 1 α-hydroxylase expressed in Escherichia coli. Eur J Biochem. 1999 Feb;259(3):731-8.

[4]. Norman AW, Okamura WH, Bishop JE, Henry HL. Update on biological actions of 1α,25(OH)2-vitamin D3 (rapid effects) and 24R,25(OH)2-vitamin D3. Mol Cell Endocrinol. 2002 Nov 29;197(1-2):1-13

[5]. Hurst-Kennedy J, Zhong M, Gupta V et al. 24R,25-Dihydroxyvitamin D3, lysophosphatidic acid, and p53: a signaling axis in the inhibition of phosphate-induced chondrocyte apoptosis. J Steroid Biochem Mol Biol. 2010 Oct;122(4):264-71.

[6]. Wehmeier KR, Alamir AR, Sultan S, et al. 24, 25-dihydroxycholecalciferol but not 25-hydroxycholecalciferol suppresses apolipoprotein A-I gene expression. Life Sci. 2011 Jan 3;88(1-2):110-6.

[7]. Rubin LP, Yeung B, Vouros P et al. Evidence for human placental synthesis of 24,25-dihydroxyvitamin D3 and 23,25-dihydroxyvitamin D3. Pediatr Res. 1993 Jul;34(1):98-104.

Secalciferol-d6物理化学性质

[ 分子式 ]:
C₂₇H₃₈D₆O₃

[ 分子量 ]:
422.68

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相关化合物

[Secalciferol-d6]化源网提供Secalciferol-d6CAS号1440957-55-0，Secalciferol-d6MSDS及其说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。CAS号查询Secalciferol-d6上化源网，专业又轻松。>>电脑版：Secalciferol-d6

标题：【Secalciferol-d6】Secalciferol-d6 CAS号:1440957-55-0【结构式性质活性】-化源网地址：https://www.chemsrc.com/amp/cas/1440957-55-0_1682416.html