1-(2,3-二氢-1,4-苯并二恶英-5-基)-4-(2,3-二氢-1H-茚满-2-基)哌嗪

S-15535 是一种具有高选择性的 5-HT1A 受体配体。S-15535 是突触后 5-HT1A 受体的拮抗剂,也是突触前 5-HT1A 受体的激动剂。S-15535 可用于精神疾病的研究,如抗焦虑。

[ 描述 ]:

[ 相关类别 ]:

[ 靶点 ]

[参考文献]

[ 密度 ]:
1.228g/cm3

[ 沸点 ]:
504.5ºC at 760mmHg

[ 分子式 ]:
C₂₁H₂₄N₂O₂

[ 分子量 ]:
336.42700

[ 闪点 ]:
148.9ºC

[ 精确质量 ]:
336.18400

[ PSA ]:
24.94000

[ LogP ]:
2.75010

[ 外观性状 ]:
白色固体

[ 蒸汽压 ]:
2.63E-10mmHg at 25°C

[ 折射率 ]:
1.628

[ 储存条件 ]:
2-8℃

[ 符号 ]:

GHS09

[ 信号词 ]:
Warning

[ 危害声明 ]:
H400

[ 警示性声明 ]:
P273

[ 个人防护装备 ]:
Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi

[ 危险品运输编码 ]:
UN 3077 9 / PGIII

S 15535, a novel benzodioxopiperazine ligand of serotonin (5-HT)1A receptors: I. Interaction with cloned human (h)5-HT1A, dopamine hD2/hD3 and h alpha2A-adrenergic receptors in relation to modulation of cortical monoamine release and activity in models of potential antidepressant activity.

J. Pharmacol. Exp. Ther. 282(1) , 132-47, (1997)

The novel, potential anxiolytic, S 15535 (4-(benzodioxan-5-yl)1-(indan-2-yl)piperazine), is an agonist and antagonist (weak partial agonist) at pre- and postsynaptic serotonin (5-HT)1A receptors, resp...

Differential modulation by GTPgammaS of agonist and inverse agonist binding to h5-HT(1A) receptors revealed by [3H]-WAY100,635.

Br. J. Pharmacol. 132(2) , 518-24, (2001)

1. The interaction of serotonergic ligands at human (h) 5-HT(1A) receptors expressed in Chinese hamster ovary cells was examined with the selective 'neutral' 5-HT(1A) antagonist [(3)H]-WAY100,635. Its...

Improvement in the selectivity and metabolic stability of the serotonin 5-HT(1A) ligand, S 15535: a series of cis- and trans-2-(arylcycloalkylamine) 1-indanols.

J. Med. Chem. 45(1) , 165-76, (2002)

S 15535 (1) displays a distinctive profile of agonist and antagonist (weak partial agonist) activity at pre- and postsynaptic 5-HT(1A) receptors, respectively. It has proven to be active in several mo...

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公司名：上海化源世纪贸易有限公司

区域：上海市普陀区

价格：

联系人：徐经理

产品详情：1-(2,3-二氢-1,4-苯并二恶英-5-基)-4-(2,3-二氢-1H-茚满-2-基)哌嗪

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公司名：上海创赛科技有限公司

区域：上海市嘉定区

价格：
￥655.0/5mg ￥2186.0/25mg ￥5829.0/100mg

联系人：夏言

产品详情：[Perfemiker]1-(2，3-二氢-1，4-苯并二恶英-5-基)-4-(2，3-二氢-1H-茚满-2-基)哌嗪,95%

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