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2-piperidin-1-ylethyl 4-amino-5-chloro-2-methoxybenzoate

用途

ML 10302是一种有效的激动剂5-HT4受体,Ki为1.07 nM。5-羟色胺(5-HT4)受体激动剂通过胆碱能途径刺激肠道运动。ML10302通过激活胆碱能通路,在小肠和结肠中诱导显著的运动前收缩。ML 10302还具有研究神经病学疾病的潜力【1】。

名称

[ CAS 号 ]:
148868-55-7

[ 英文名 ]:
2-piperidin-1-ylethyl 4-amino-5-chloro-2-methoxybenzoate

[英文别名 ]:

生物活性

[ 描述 ]:

ML 10302是一种有效的激动剂5-HT4受体,Ki为1.07 nM。5-羟色胺(5-HT4)受体激动剂通过胆碱能途径刺激肠道运动。ML10302通过激活胆碱能通路,在小肠和结肠中诱导显著的运动前收缩。ML 10302还具有研究神经病学疾病的潜力【1】。

[ 相关类别 ]:

研究领域 >> 神经疾病
信号通路 >> G 蛋白偶联受体/G 蛋白 >> 5-HT受体
信号通路 >> 神经信号通路 >> 5-HT受体

[参考文献]

[1]. Cachard-Chastel M, et al. 5-HT4 receptor agonists increase sAPPalpha levels in the cortex and hippocampus of male C57BL/6j mice. Br J Pharmacol. 2007;150(7):883-892.

[2]. Yang D, et al. New esters of 4-amino-5-chloro-2-methoxybenzoic acid as potent agonists and antagonists for 5-HT4 receptors. J Med Chem. 1997;40(4):608-621.

[3]. De Ponti F, et al. Intestinal motor stimulation by the 5-HT4 receptor agonist ML10302: differential involvement of tachykininergic pathways in the canine small bowel and colon. Neurogastroenterol Motil. 2001;13(6):543-553.

物理化学性质

[ 密度 ]:
1.223g/cm3

[ 沸点 ]:
472.7ºC at 760 mmHg

[ 分子式 ]:
C15H21ClN2O3

[ 分子量 ]:
312.79200

[ 闪点 ]:
239.7ºC

[ 精确质量 ]:
312.12400

[ PSA ]:
64.79000

[ LogP ]:
3.09260

[ 蒸汽压 ]:
4.18E-09mmHg at 25°C

[ 折射率 ]:
1.563

MSDS

详细MSDS(安全技术说明书)

安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
2933399090

合成路线

详细合成路线

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海关

[ 海关编码 ]: 2933399090

[ 中文概述 ]:
2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

文献

Design and synthesis of specific probes for human 5-HT4 receptor dimerization studies.

J. Med. Chem. 48 , 6220-6228, (2005)

Recently, human 5-HT4 receptors have been demonstrated to form constitutive dimers in living cells. To evaluate the role of dimerization on the 5-HT4 receptor function, we investigated the conception ...

New esters of 4-amino-5-chloro-2-methoxybenzoic acid as potent agonists and antagonists for 5-HT4 receptors.

J. Med. Chem. 40 , 608-621, (1997)

A number of benzoates derived from 4-amino-5-chloro-2-methoxybenzoic acid and substituted 1-piperidineethanol were synthesized and found to be potent 5-HT4 receptor agonists in the electrically-stimul...

Intestinal motor stimulation by the 5-HT4 receptor agonist ML10302: differential involvement of tachykininergic pathways in the canine small bowel and colon.

Neurogastroenterol. Motil. 13 , 543-553, (2001)

5-Hydroxytryptamine (5-HT)4 receptor agonists stimulate gut motility through cholinergic pathways, although there are data suggesting that noncholinergic (tachykininergic) excitatory pathways may also...


更多文献

推荐生产厂家/供应商：

公司名：上海化源世纪贸易有限公司

区域：上海市普陀区

价格：

联系人：徐经理

产品详情：ML 10302

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相关化合物

CAS号[148868-55-7]化源网提供[2-piperidin-1-ylethyl 4-amino-5-chloro-2-methoxybenzoate]MSDS、说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。>>电脑版：2-piperidin-1-ylethyl 4-amino-5-chloro-2-methoxybenzoate

标题：【2-piperidin-1-ylethyl 4-amino-5-chloro-2-methoxybenzoate】2-piperidin-1-ylethyl 4-amino-5-chloro-2-methoxybenzoate CAS号:148868-55-7【结构式 性质 活性】-化源网 地址：https://www.chemsrc.com/amp/cas/148868-55-7_1195242.html