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2-巯基苯并噻唑

2-巯基苯并噻唑用途

2-Mercaptobenzothiazole 是一种内源性代谢产物。

2-巯基苯并噻唑名称

[ CAS 号 ]:
149-30-4

[ 中文名 ]:
2-巯基苯并噻唑

[ 英文名 ]:
2-Mercaptobenzothiazole

[中文别名 ]:

[英文别名 ]:

AG 63
T56 BMYSJ CUS
ROTAX
2-Benzothiazolethiol,MBT
2-mercapto-benzothiazole
2-Benzothiazolethiol (MBT)
2-sulfanyl-1,3-benzothiazole
2-MBT
Sulfur Accelerator M
CAPTAX

2-巯基苯并噻唑生物活性

[ 描述 ]:

2-Mercaptobenzothiazole 是一种内源性代谢产物。

[ 相关类别 ]:

研究领域 >> 代谢疾病

2-巯基苯并噻唑物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 沸点 ]:
305.0±25.0 °C at 760 mmHg

[ 熔点 ]:
177-181 °C(lit.)

[ 分子式 ]:
C₇H₅NS₂

[ 分子量 ]:
167.251

[ 闪点 ]:
243 ºC (dec.)

[ 精确质量 ]:
166.986343

[ PSA ]:
79.93000

[ LogP ]:
2.38

[ 外观性状 ]:
米色或淡黄色粉末带有一种微弱气味

[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C

[ 折射率 ]:
1.784

[ 储存条件 ]:
通风低温干燥,与库房食品原料,酸类和氧化剂分开存放

[ 稳定性 ]:
Stable. Incompatible with strong oxidizing agents. Flammable.

[ 水溶解性 ]:
<0.1 g/100 mL at 19 ºC

2-巯基苯并噻唑MSDS

2-巯基苯并噻唑毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DL6475000

CHEMICAL NAME :: 2-Benzothiazolethiol

CAS REGISTRY NUMBER :: 149-30-4

LAST UPDATED :: 199710

DATA ITEMS CITED :: 29

MOLECULAR FORMULA :: C7-H5-N-S2

MOLECULAR WEIGHT :: 167.25

WISWESSER LINE NOTATION :: T56 BN DSJ CSH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >1270 mg/m3

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1158 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >7940 mg/kg

TOXIC EFFECTS :: Behavioral - food intake (animal) Behavioral - changes in motor activity (specific assay)

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - quail

DOSE/DURATION :: >2150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 12220 mg/kg/13W-I

TOXIC EFFECTS :: Liver - changes in liver weight

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 18 gm/kg/16D-I

TOXIC EFFECTS :: Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 97500 mg/kg/13W-I

TOXIC EFFECTS :: Liver - changes in liver weight Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 174 gm/kg/86W-C

TOXIC EFFECTS :: Kidney, Ureter, Bladder - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 770 mg/kg/7D-I

TOXIC EFFECTS :: Liver - hepatitis (hepatocellular necrosis), zonal Liver - liver function tests impaired

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 195 gm/kg/2Y-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Blood - leukemia Gastrointestinal - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 35 gm/kg/78W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors Blood - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 215 mg/kg

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Blood - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 195 gm/kg/2Y-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Parenteral

DOSE :: 800 mg/kg

SEX/DURATION :: male 2 day(s) pre-mating female 2 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Embryo or Fetus - fetal death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Parenteral

DOSE :: 400 mg/kg

SEX/DURATION :: female 4-11 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Embryo or Fetus - fetal death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 4176 mg/kg

SEX/DURATION :: female 6-14 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - eye/ear Reproductive - Specific Developmental Abnormalities - gastrointestinal system

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 351 mg/L

REFERENCE :: NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-332,1988 *** REVIEWS *** TOXICOLOGY REVIEW JJOMDZ JOM, Journal of Occupational Medicine. (American Occupational Medicine Assoc., 150 N. Wacker Dr., Chicago, IL 60606) V.10- 1968- Volume(issue)/page/year: 15,808,1973 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84030 No. of Facilities: 2428 (estimated) No. of Industries: 45 No. of Occupations: 40 No. of Employees: 42637 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84030 No. of Facilities: 4825 (estimated) No. of Industries: 74 No. of Occupations: 62 No. of Employees: 86509 (estimated) No. of Female Employees: 16409 (estimated)

2-巯基苯并噻唑安全信息

[ 符号 ]:

GHS07, GHS09

[ 信号词 ]:
Warning

[ 危害声明 ]:
H317-H410

[ 警示性声明 ]:
P273-P280-P501

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant

[ 风险声明 (欧洲) ]:
R43;R50/53

[ 安全声明 (欧洲) ]:
S24-S37-S60-S61

[ 危险品运输编码 ]:
UN 3077 9/PG 3

[ WGK德国 ]:
2

[ RTECS号 ]:
DL6475000

[ 包装等级 ]:
I; II; III

[ 危险类别 ]:
6.1

[ 海关编码 ]:
29342020

2-巯基苯并噻唑合成路线

2-巯基苯并噻唑上下游产品

2-巯基苯并噻唑上游产品

2-巯基苯并噻唑下游产品

2-巯基苯并噻唑制备

1. 该品有许多生产方法，但主要是分别以苯胺、邻硝基氯苯和二苯硫脲为原料的3种方法。1.以苯胺为原料通常是将苯胺、二硫化碳和硫磺在高压釜中直接反应，也可用脂肪胺、二甲基甲酰胺、三噻唑烷和多取甲醛等代替二硫化碳，使苯胺和硫磺的压力下反应。用苯胺为原料的方法，其反应压力都较高，一般在4MPa以上，有高达15MPa，因此也称高压法。

2. 以邻硝基氯苯为原料邻硝基氯苯与还原剂硫氢化钠、多硫化钠或硫化氢反应都可还原成邻氨基硫酚。进一步与二硫化碳反应而制得促进剂M。这类方法有的反应时间较长（硫氢化钠约需20h），但都可在常压或较低压力下进行，又称常压法。

3. 以二苯硫脲为原料此法的反应压力介于前述两种方法之间，在4MPa以下，一般称中压法。见水处理剂 03301。

4. 其制备方法是以邻氯硝基苯、多硫化钠、二硫化碳为原料，在110～130℃温度、343kPa压力下反应生成2-巯基苯并噻唑钠盐，再用硫酸进行酸化、水洗得产品。

5. 工业上大多采用邻硝基氯苯法、苯胺法、硝基苯和苯胺混合法三种方法生产。苯胺法合成M是我国各助剂厂普遍采用的方法。在合成釜中投入一定比例的苯胺、CS2和硫黄，在搅拌下升温，在温度240～260℃、压力9.0～10.0MPa下保温反应3h。反应结束后于一定pH值条件下碱溶，除去不溶物，溶液经酸化、脱水和干燥后得到产品促进剂M。也可以采用苯胺为主要原料，先与二硫化碳生成犖取代含硫化合物，再在浓硫酸和溴化钠存在下合环反应得产物，反应均在常温常压下进行，产率达90%。合成反应式如下

6. 常压法　将硫化钠、硫磺制成多硫化钠，然后将多硫化钠、邻硝基氯苯、二硫化碳在100～130℃和低于0.34MPa压力下，缩合成2-巯基苯并噻唑的钠盐。经25%～30%的硫酸进行一次酸化（ph值2～3）、水洗（80℃）、氢氧化钠碱溶 (ph值11.5～12）、过滤、硫酸二次酸化（温度60～65℃，ph值4～5）、中和、水洗、干燥、粉碎，即为成品。

2-巯基苯并噻唑海关

[ 海关编码 ]: 2933199090

[ 中文概述 ]:
2933199090. 其他结构上有非稠合吡唑环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933199090. other compounds containing an unfused pyrazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

2-巯基苯并噻唑文献

Micro-scale strategy to detect spermine and spermidine by MALDI-TOF MS in foods and identification of apoptosis-related proteins by nano-flow UPLC-MS/MS after treatment with spermine and spermidine.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 978-979 , 131-7, (2015)

Spermine and spermidine are multiple-nitrogen compounds found in many foods. Both compounds are essential for cell growth and human health. This study established a simple and fast method of detecting...

Simple analytical strategy for MALDI-TOF-MS and nanoUPLC-MS/MS: quantitating curcumin in food condiments and dietary supplements and screening of acrylamide-induced ROS protein indicators reduced by curcumin.

Food Chem. 174 , 571-6, (2014)

Curcumin is the major active ingredient of turmeric and is widely used as a preservative, flavouring and colouring agent. Curcumin is a potent substance with several functions, including antioxidant, ...

Rapid and sensitive LC-MS-MS determination of 2-mercaptobenzothiazole, a rubber additive, in human urine.

Anal. Bioanal. Chem 407(12) , 3417-23, (2015)

2-Mercaptobenzothiazole (MBT) is one of the most important vulcanization accelerators in the industrial production of rubber, especially car tires. Given its wide use in household articles and industr...

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