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普拉格雷

普拉格雷用途

Prasugrel是ADP受体抑制剂,能通过不可逆的与P2Y12受体结合降低血小板的聚集。

普拉格雷名称

[ CAS 号 ]:
150322-43-3

[ 中文名 ]:
普拉格雷

[ 英文名 ]:
Prasugrel

[中文别名 ]:

普拉格雷中间体-2

[英文别名 ]:

Prasugrel
Unii-34K66tbt99
Effient
Efient

普拉格雷生物活性

[ 描述 ]:

Prasugrel是ADP受体抑制剂,能通过不可逆的与P2Y12受体结合降低血小板的聚集。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> P2Y受体

研究领域 >> 心血管疾病

[参考文献]

[1]. Pharmacokinetic basis of the antiplatelet action of prasugrel By Schroer, Karsten; Siller-Matula, Jolanta M.; Huber, Kurt From Fundamental & Clinical Pharmacology (2012), 26(1), 39-46.

[2]. Selective Blockade of P2Y12 Receptors by Prasugrel Inhibits Myocardial Infarction Induced by Thrombotic Coronary Artery Occlusion in Rats By Sugidachi, Atsuhiro; Yamaguchi, Shinji; Jakubowski, Joseph A.; Ohno, Kosaku; Tomizawa, Atsuyuki; Hashimoto, Masami; Niitsu, Yoichi From Journal of Cardiovascular Pharmacology (2011), 58(3), 329-334.

[3]. Darius H.Prasugrel.Hamostaseologie. 2012 Aug 1;32(3):186-90.

[4]. Alexopoulos D, Galati A, Xanthopoulou I, Mavronasiou E, Kassimis G, Theodoropoulos KC, Makris G, Damelou A, Tsigkas G, Hahalis G, Davlouros P.Ticagrelor versus prasugrel in acute coronary syndrome patients with high on-clopidogrel platelet reactivity following percutaneous coronary intervention: a pharmacodynamic study.J Am Coll Cardiol. 2012 Jul 17;60(3):193-9.

[5]. Spiel AO, Derhaschnig U, Schwameis M, Bartko J, Siller-Matula JM, Jilma B.Effects of prasugrel on platelet inhibition during systemic endotoxaemia: a randomized controlled trial.Clin Sci (Lond). 2012 Nov 1;123(10):591-600.

[相关活性小分子]

普拉格雷物理化学性质

[ 密度 ]:
1.347

[ 沸点 ]:
493.5ºC at 760 mmHg

[ 熔点 ]:
122 °C

[ 分子式 ]:
C₂₀H₂₀FNO₃S

[ 分子量 ]:
373.44100

[ 闪点 ]:
252.3ºC

[ 精确质量 ]:
373.11500

[ PSA ]:
74.85000

[ LogP ]:
3.82890

[ 外观性状 ]:
白色固体

[ 蒸汽压 ]:
0mmHg at 25°C

[ 折射率 ]:
1.619

[ 储存条件 ]:
2-8°C

普拉格雷MSDS

普拉格雷安全信息

[ 危害码 (欧洲) ]:
Xi

[ 危险品运输编码 ]:
NONH for all modes of transport

普拉格雷合成路线

普拉格雷上下游产品

普拉格雷上游产品

普拉格雷下游产品

普拉格雷文献

Human valacyclovir hydrolase/biphenyl hydrolase-like protein is a highly efficient homocysteine thiolactonase.

PLoS ONE 9(10) , e110054, (2014)

Homocysteinylation of lysine residues by homocysteine thiolactone (HCTL), a reactive homocysteine metabolite, results in protein aggregation and malfunction, and is a well-known risk factor for cardio...

Effect of grapefruit juice on the bioactivation of prasugrel.

Br. J. Clin. Pharmacol. 80 , 139-45, (2015)

The P2Y12 inhibitor prasugrel is a prodrug, which is activated after its initial hydrolysis partly by cytochrome P450 (CYP) 3A4. Grapefruit juice, a strong inactivator of intestinal CYP3A4, greatly re...

Safety of short-term dual antiplatelet therapy after drug-eluting stents: An updated meta-analysis with direct and adjusted indirect comparison of randomized control trials.

Int. J. Cardiol. 181 , 331-9, (2015)

Duration of dual antiplatelet therapy (DAPT) following drug-eluting stents (DES) remains controversial and is a topic of ongoing research.Direct and adjusted indirect comparisons of all the recent ran...

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