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醋硝香豆素

醋硝香豆素用途

Acenocoumarol是一种抗凝血剂,功能如同一个Vitamin K拮抗剂。

醋硝香豆素名称

[ CAS 号 ]:
152-72-7

[ 中文名 ]:
醋硝香豆素

[ 英文名 ]:
acenocoumarol

[中文别名 ]:

醋硝香豆酮

[英文别名 ]:

UNII:I6WP63U32H
Trombostop
EINECS 205-807-3
MFCD00137816
3-(a-Acetonyl-p-nitrobenzyl)-4-hydroxycoumarin
acenocoumarol

醋硝香豆素生物活性

[ 描述 ]:

Acenocoumarol是一种抗凝血剂,功能如同一个Vitamin K拮抗剂。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 心血管疾病

[相关活性小分子]

醋硝香豆素物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
592.7±50.0 °C at 760 mmHg

[ 熔点 ]:
196-199ºC

[ 分子式 ]:
C₁₉H₁₅NO₆

[ 分子量 ]:
353.326

[ 闪点 ]:
312.3±30.1 °C

[ 精确质量 ]:
353.089935

[ PSA ]:
113.33000

[ LogP ]:
3.15

[ 外观性状 ]:
白色结晶固体

[ 蒸汽压 ]:
0.0±1.8 mmHg at 25°C

[ 折射率 ]:
1.656

[ 储存条件 ]:
库房通风低温干燥,与食品添加剂分开存放

[ 水溶解性 ]:
DMSO, heptane and xylene: ≥17mg/mL

醋硝香豆素毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GN4900000

CHEMICAL NAME :: Coumarin, 3-(alpha-acetonyl-p-nitrobenzyl)-4-hydroxy-

CAS REGISTRY NUMBER :: 152-72-7

LAST UPDATED :: 199504

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C19-H15-N-O6

MOLECULAR WEIGHT :: 353.35

WISWESSER LINE NOTATION :: T66 BOVJ DY1V1&R DNW& EQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 513 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 29ZVAB "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969 Volume(issue)/page/year: -,3,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1470 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 11,85,1956

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 115 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989 Volume(issue)/page/year: 11,6,1989 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Unreported

DOSE :: 24 mg/kg

SEX/DURATION :: female 1-28 week(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)

REFERENCE :: AFPEAM Archives Francaises de Pediatrie. (Doin Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1942- Volume(issue)/page/year: 36,63,1979 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X7380 No. of Facilities: 8 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 239 (estimated) No. of Female Employees: 157 (estimated)

醋硝香豆素安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H315-H319-H335

[ 警示性声明 ]:
P301 + P312 + P330-P305 + P351 + P338

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
63-22-36/37/38

[ 安全声明 (欧洲) ]:
26-36/37

[ 危险品运输编码 ]:
UN 2811

[ RTECS号 ]:
GN4900000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

[ 海关编码 ]:
2932209090

醋硝香豆素合成路线

详细合成路线

醋硝香豆素上下游产品

醋硝香豆素上游产品

醋硝香豆素下游产品

醋硝香豆素制备

将4-羟基香豆素和4-对硝基苯基丁烯-3-酮进行加成反应，得到的新抗凝粗品用丙酮重结晶，总收率55%。

醋硝香豆素海关

[ 海关编码 ]: 2932209090

[ 中文概述 ]:
2932209090. 其他内酯. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

醋硝香豆素文献

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A generic chiral separation strategy for the analysis of acidic compounds in CEC is proposed in completion of an earlier defined strategy for nonacidic compounds. The screening step of this strategy u...

A rapid method for determination of 22 selected drugs in human urine by UHPLC/MS/MS for clinical application.

J. AOAC Int. 97(6) , 1526-37, (2015)

A rapid and sensitive ultra-HPLC/MSIMS (UHPLC/MSIMS) assay method for the simultaneous determination in human urine of 22 drugs belonging to different pharmaceutical groups was developed. The drugs we...

Prophylaxis of experimental endocarditis with antiplatelet and antithrombin agents: a role for long-term prevention of infective endocarditis in humans?

J. Infect. Dis. 211(1) , 72-9, (2014)

Infective endocarditis (IE) mostly occurs after spontaneous low-grade bacteremia. Thus, IE cannot be prevented by circumstantial antibiotic prophylaxis. Platelet activation following bacterial-fibrino...

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