芦丁

Rutin是天然的黄酮苷,具有抗炎,抗氧化、抗过敏、抗病毒等功效。

信号通路 >> 自噬 >> 自噬

天然产物 >> 黄酮类化合物

研究领域 >> 炎症/免疫

[1]. E. H. Aksu, et al. Rutin ameliorates cisplatin-induced reproductive damagevia suppression of oxidative stress and apoptosis in adultmale rats. Andrologia. 2016 Apr 23.

[2]. Han YH, et al. Lipin1-Mediated Repression of Adipogenesis by Rutin.Am J Chin Med. 2016;44(3):565-78

[3]. Lu N, et al. Effects of rutin on the redox reactions of hemoglobin. Int J Biol Macromol. 2016 Apr 25;89:175-180.

雷帕霉素 | 蛋白酶体抑制剂 | 放线菌酮 | 3-甲基腺嘌呤 | LY294002 | 瑞沙托维 | (+)-JQ1 | 4-(4-氟苯基)-2-(4-甲基亚磺酰基苯基)-5-(4-吡啶基)-1H-咪唑 | 吡唑蒽酮(SP600125) | U0126-EtOH | 放线菌素D | 磷酸氯喹 | CHIR-99021 (CT99021) | MK-2206 2HCl | Dorsomorphin dihydrochloride

DATA ITEMS CITED :

12

MOLECULAR FORMULA :

C27-H30-O16

MOLECULAR WEIGHT :

610.57

WISWESSER LINE NOTATION :

T66 BO EVJ CR CQ DQ& GQ IQ DO- BT6OTJ CQ DQ EQ F1O- BT6OTJ CQ DQ EQ F1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

2 gm/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

200 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

950 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - guinea pig

DOSE/DURATION :

2 gm/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

973 gm/kg/3Y-C

TOXIC EFFECTS :

Tumorigenic - neoplastic by RTECS criteria Liver - tumors

TYPE OF TEST :

Specific locus test

MUTATION DATA

TYPE OF TEST :

Body fluid assay

TEST SYSTEM :

Rodent - rat Bacteria - Salmonella typhimurium

DOSE/DURATION :

2 gm/kg

REFERENCE :

FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 25,9,1987 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80506 No. of Facilities: 68 (estimated) No. of Industries: 1 No. of Occupations: 6 No. of Employees: 2770 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80506 No. of Facilities: 19 (estimated) No. of Industries: 1 No. of Occupations: 9 No. of Employees: 934 (estimated) No. of Female Employees: 506 (estimated)