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1-(4-甲基苯基)-1H-吡咯-2,5-二酮

1-(4-甲基苯基)-1H-吡咯-2,5-二酮用途

p-Tolylmaleimide is a water channel inhibitor which binds to aquaporin Z (AqpZ).

1-(4-甲基苯基)-1H-吡咯-2,5-二酮名称

[ CAS 号 ]:
1631-28-3

[ 中文名 ]:
1-(4-甲基苯基)-1H-吡咯-2,5-二酮

[ 英文名 ]:
p Tolylmaleimide

[英文别名 ]:

n-p-tolyl-maleimid
N-4-Tolylmaleimide
Maleimide,N-p-Tolyl
MFCD00022581
p-Tolylmaleimide
IT 510

1-(4-甲基苯基)-1H-吡咯-2,5-二酮物理化学性质

[ 密度 ]:
1.277g/cm3

[ 沸点 ]:
333.2ºC at 760mmHg

[ 分子式 ]:
C₁₁H₉NO₂

[ 分子量 ]:
187.19500

[ 闪点 ]:
154.2ºC

[ 精确质量 ]:
187.06300

[ PSA ]:
37.38000

[ LogP ]:
1.48940

[ 蒸汽压 ]:
0.000139mmHg at 25°C

[ 折射率 ]:
1.615

[ 储存条件 ]:
室温，密封，干燥

1-(4-甲基苯基)-1H-吡咯-2,5-二酮毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: ON6475000

CHEMICAL NAME :: Maleimide, N-p-tolyl-

CAS REGISTRY NUMBER :: 1631-28-3

BEILSTEIN REFERENCE NO. :: 0131320

LAST UPDATED :: 199612

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C11-H9-N-O2

MOLECULAR WEIGHT :: 187.21

WISWESSER LINE NOTATION :: T5VNVJ BR D1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 710 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 23,95,1962

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NCNSA6 National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review. (Washington, DC) Volume(issue)/page/year: 5,22,1953

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 360 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 23,95,1962

1-(4-甲基苯基)-1H-吡咯-2,5-二酮安全信息

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 海关编码 ]:
2925190090

1-(4-甲基苯基)-1H-吡咯-2,5-二酮合成路线

详细合成路线

1-(4-甲基苯基)-1H-吡咯-2,5-二酮上下游产品

1-(4-甲基苯基)-1H-吡咯-2,5-二酮上游产品

1-(4-甲基苯基)-1H-吡咯-2,5-二酮下游产品

1-(4-甲基苯基)-1H-吡咯-2,5-二酮海关

[ 海关编码 ]: 2925190090

[ 中文概述 ]:
2925190090 其他酰亚胺及其衍生物盐. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2925190090 other imides and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%