1631-28-3

• 常用中文名：1-(4-甲基苯基)-1H-吡咯-2,5-二酮
• 常用英文名：p Tolylmaleimide
• CAS号：1631-28-3
• 分子式：C₁₁H₉NO₂
• 分子量：187.19500
• 发布时间：2018-12-03 18:19:28
• 更新时间：2024-01-12 16:24:05
• p-Tolylmaleimide is a water channel inhibitor which binds to aquaporin Z (AqpZ).

名称

• 中文名: 1-(4-甲基苯基)-1H-吡咯-2,5-二酮
• 英文名: 1-(4-methylphenyl)-1h-pyrrole-2,5-dione
• 英文别名: n-p-tolyl-maleimid; N-4-Tolylmaleimide; Maleimide,N-p-Tolyl; MFCD00022581; p-Tolylmaleimide; IT 510

物化性质

• 密度: 1.277g/cm3
• 沸点: 333.2ºC at 760mmHg
• 分子式: C₁₁H₉NO₂
• 分子量: 187.19500
• 闪点: 154.2ºC
• 精确质量: 187.06300
• PSA: 37.38000
• LogP: 1.48940
• 蒸汽压: 0.000139mmHg at 25°C
• 折射率: 1.615
• 储存条件: 室温， 密封， 干燥
• 计算化学:

  1.疏水参数计算参考值（XlogP）:无

  2.氢键供体数量:0

  3.氢键受体数量:2

  4.可旋转化学键数量:1

  5.互变异构体数量:无

  6.拓扑分子极性表面积37.4

  7.重原子数量:14

  8.表面电荷:0

  9.复杂度:270

  10.同位素原子数量:0

  11.确定原子立构中心数量:0

  12.不确定原子立构中心数量:0

  13.确定化学键立构中心数量:0

  14.不确定化学键立构中心数量:0

  15.共价键单元数量:1

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : ON6475000 CHEMICAL NAME : Maleimide, N-p-tolyl- CAS REGISTRY NUMBER : 1631-28-3 BEILSTEIN REFERENCE NO. : 0131320 LAST UPDATED : 199612 DATA ITEMS CITED : 3 MOLECULAR FORMULA : C11-H9-N-O2 MOLECULAR WEIGHT : 187.21 WISWESSER LINE NOTATION : T5VNVJ BR D1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 710 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 23,95,1962 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 50 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NCNSA6 National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review. (Washington, DC) Volume(issue)/page/year: 5,22,1953 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 360 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 23,95,1962

安全

• 危害码 (欧洲): Xi: Irritant;
• 海关编码: 2925190090

合成路线

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海关

海关编码	2925190090
中文概述	2925190090 其他酰亚胺及其衍生物盐. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:6.5% 普通关税:30.0%
申报要素	品名, 成分含量, 用途
Summary	2925190090 other imides and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%