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DC-胆固醇

DC-胆固醇用途

在合适的实验条件下,DC-Chol盐酸盐能抑制Aβ40原纤维的形成。DC-Chol盐酸盐以剂量依赖性方式强烈抑制氧化hCT的淀粉样变性[1][2]。

DC-胆固醇名称

[ CAS 号 ]:
166023-21-8

[ 中文名 ]:
O-[(N,N-二甲基氨基乙基)-氨基甲酰基]胆固醇盐酸盐

[ 英文名 ]:
DC-cholesterol hydrochloride

[中文别名 ]:

DC-胆固醇

[英文别名 ]:

DC-cholesterol hydrochloride
marinobufotoxin
3β-[N-(Dimethylaminoethane)carbamoyl]cholesterol

DC-胆固醇生物活性

[ 描述 ]:

在合适的实验条件下,DC-Chol盐酸盐能抑制Aβ40原纤维的形成。DC-Chol盐酸盐以剂量依赖性方式强烈抑制氧化hCT的淀粉样变性[1][2]。

[ 相关类别 ]:

研究领域 >> 神经疾病

[参考文献]

[1]. Esmail A Elbassal, et al. Effects of Charged Cholesterol Derivatives on Aβ40 Amyloid Formation. J Phys Chem B. 2016 Jan 14;120(1):59-68.

[2]. Richard Lantz, et al. Effects of disulfide bond and cholesterol derivatives on human calcitonin amyloid formation. Biopolymers. 2020 May;111(5):e23343.

DC-胆固醇物理化学性质

[ 分子式 ]:
C₃₂H₅₇ClN₂O₂

[ 分子量 ]:
537.26000

[ 精确质量 ]:
536.41100

[ PSA ]:
45.06000

[ LogP ]:
8.69060

[ 外观性状 ]:
白色粉末

[ 储存条件 ]:
-20℃，密封，干燥

DC-胆固醇安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

DC-胆固醇文献

In vitro liposome-mediated DNA transfection of epithelial cell lines using the cationic liposome DC-Chol/DOPE.

Gene Ther. 2 , 603-613, (1995)

Clinical trials using cationic liposome-mediated DNA transfer have now been initiated for several disorders including cystic fibrosis. Previous studies have shown that the level of gene expression ach...

Lipofection reagents prepared by a simple ethanol injection technique.

Biotechniques 18 , 1027-1032, (1995)

Cationic liposomes are being utilized for the delivery of DNA into mammalian cells both in vitro and in vivo. In this report, we describe a rapid, simple injection method for the preparation of cation...

The use of cationic liposomes DC-CHOL/DOPE and DDAB/DOPE for direct transfer of Escherichia coli cytosine deaminase gene into growing melanoma tumors.

Gene Ther. 3 , 1026-1031, (1996)

An attempt was made to use simple cationic liposomes DC-Chol/DOPE and DDAB/DOPE (DC-Chol is 3 beta (N(N',N-dimethylaminoethane) carbamoyl) cholesterol, DDAB is dimethyldioctadecyl ammonium bromide and...

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