3-(二甲基氨基)丙腈

3-(二甲基氨基)丙腈用途

【用途一】
用于固氮酶细胞分析中蛋白质、酶、核酸分子量的圆盘电泳法的测定
【用途二】
β-二甲氨基丙腈是杀菌剂霜霉威的中间体。
【用途三】
有机合成中间体，用于合成多种维生素B，也可用作有机溶剂、高分子合成引发剂（促聚剂）以及电镀添加剂的中间体。作为分析试剂，用于固氮酶细胞的分析中蛋白质、酶、核梅分子量的圆盘电泳法的测定。

3-(二甲基氨基)丙腈名称

[ CAS 号 ]:
1738-25-6

[ 中文名 ]:
二甲氨基丙腈

[ 英文名 ]:
Dimethylaminopropionitrile

[中文别名 ]:

[英文别名 ]:

2-DIMETHYLAMINOETHYL CYANIDE
Cyanogum41catalyst
MFCD00001957
3-(Dimethylamino)propanenitrile
3-(DIMETHYLAMINO)PROPIONITRILE
EINECS 217-090-4
Dimethylaminopropion
3-(N,N-dimethylamino)-propionitrile
3-dimethylaminopropannitril
3-(dimethylamino)-propionitril

3-(二甲基氨基)丙腈物理化学性质

[ 密度 ]:
0.87 g/mL at 25 °C(lit.)

[ 沸点 ]:
171 °C750 mm Hg(lit.)

[ 熔点 ]:
−43 °C(lit.)

[ 分子式 ]:
C₅H₁₀N₂

[ 分子量 ]:
98.14630

[ 闪点 ]:
145 °F

[ 精确质量 ]:
98.08440

[ PSA ]:
27.03000

[ LogP ]:
0.46168

[ 外观性状 ]:
无色,非固定的流体

[ 蒸汽压 ]:
1.24mmHg at 25°C

[ 折射率 ]:
n20/D 1.426(lit.)

[ 储存条件 ]:
库房通风低温干燥,与食品、氧化剂、酸类分开储运

[ 水溶解性 ]:
0.5 g/L (20 ºC)

3-(二甲基氨基)丙腈MSDS

3-(二甲基氨基)丙腈毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UG1575000

CHEMICAL NAME :: Propionitrile, 3-(dimethylamino)-

CAS REGISTRY NUMBER :: 1738-25-6

BEILSTEIN REFERENCE NO. :: 0773779

LAST UPDATED :: 199710

DATA ITEMS CITED :: 12

MOLECULAR FORMULA :: C5-H10-N2

MOLECULAR WEIGHT :: 98.17

WISWESSER LINE NOTATION :: NC2N1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,923,1986

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,923,1986 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2600 uL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 23,95,1962

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,923,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 180 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#00201

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1410 uL/kg

REFERENCE :: AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 23,95,1962 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 10 mg/m3 JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO DIMETHYLAMINOPROPIONITRILE-air:min expos to NIAX REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M3293 No. of Facilities: 145 (estimated) No. of Industries: 2 No. of Occupations: 3 No. of Employees: 1990 (estimated)

3-(二甲基氨基)丙腈安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302 + H312-H319

[ 警示性声明 ]:
P280-P305 + P351 + P338

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
R21;R36/38

[ 安全声明 (欧洲) ]:
S26-S36/37-S24/25

[ 危险品运输编码 ]:
2927

[ WGK德国 ]:
1

[ RTECS号 ]:
UG1575000

[ 包装等级 ]:
II

[ 危险类别 ]:
6.1(a)

[ 海关编码 ]:
29269095

3-(二甲基氨基)丙腈合成路线

3-(二甲基氨基)丙腈上下游产品

3-(二甲基氨基)丙腈上游产品

3-(二甲基氨基)丙腈下游产品

3-(二甲基氨基)丙腈制备

由丙烯腈与二甲胺反应而得。先将丙烯腈在冰冷却下加入二甲胺溶液中，然后进行加热，通过吸收，分馏精馏，收集171-173℃馏分，即得本品。原料消耗定额：丙烯腈670kg/t、二甲胺（40%）1500kg/t。其制备方法是在反应釜中投入丙烯腈，开动搅拌和夹套水，在适宜的温度下通入二甲胺气体至规定量，反应1h取样分析得产品。反应方程式：

3-(二甲基氨基)丙腈海关

[ 海关编码 ]: 2926909090

[ 中文概述 ]:
2926909090 其他腈基化合物. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
HS:2926909090 other nitrile-function compounds VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

3-(二甲基氨基)丙腈文献

The urotoxic effects of N,N'-dimethylaminopropionitrile. 2. In vivo and in vitro metabolism.

Toxicol. Appl. Pharmacol. 110(1) , 61-9, (1991)

The urotoxicity and metabolism of N,N'-dimethylaminopropionitrile (DMAPN) were investigated in male Sprague-Dawley rats. Animals treated with 525 mg DMAPN/kg or equimolar doses of commercially availab...

Purification of RNA molecules by gel techniques.

Meth. Enzymol. 180 , 14-25, (1989)

[Morbidity study of employees exposed to dimethylaminopropionitrile].

Zentralbl. Arbeitsmed. Arbeitsschutz. Prophyl. Ergonomie 32(5) , 181-4, (1982)

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