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Dicarbine

Dicarbine用途

Dicarbine能够阻断多巴胺受体 (dopamine receptors) 在大脑不同部位的分布,抑制因刺激网状结构中脑部分而引起的条件反射。Dicarbine 在临床上可用于治疗精神分裂症和酒精性精神病患者。

Dicarbine名称

[ CAS 号 ]:
17411-19-7

[ 中文名 ]:
Dicarbine

[ 英文名 ]:
Dicarbine

[英文别名 ]:

Carbidine
Dicarbine

Dicarbine生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 多巴胺受体

信号通路 >> 神经信号通路 >> 多巴胺受体

研究领域 >> 神经疾病

[ 靶点 ]

Dopamine receptor[1][2].

[参考文献]

[1]. Barkov NK, et al. [Effect of carbidine on conditioned defense reflexes]. Biull Eksp Biol Med. 1975 Apr;79(4):61-4.

[2]. DICARBINE

Dicarbine物理化学性质

[ 密度 ]:
1.043g/cm3

[ 沸点 ]:
305.7ºC at 760mmHg

[ 分子式 ]:
C₁₃H₁₈N₂

[ 分子量 ]:
202.30

[ 闪点 ]:
128.8ºC

[ 精确质量 ]:
202.14700

[ PSA ]:
15.27000

[ LogP ]:
2.28410

[ 蒸汽压 ]:
0.000806mmHg at 25°C

[ 折射率 ]:
1.554

Dicarbine毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UU9990175

CHEMICAL NAME :: 1H-Pyrido(4,3-b)indole, 2,3,4,4a,5,9b-hexahydro-2,8-dimethyl-

CAS REGISTRY NUMBER :: 17411-19-7

LAST UPDATED :: 199712

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C13-H18-N2

MOLECULAR WEIGHT :: 202.33

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 357 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #3983239

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 153 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #3983239

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 237 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #3983239

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 79 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #3983239

Dicarbine安全信息

[ 海关编码 ]:
2933990090

Dicarbine合成路线

详细合成路线

Dicarbine上下游产品

Dicarbine上游产品

Dicarbine下游产品

Dicarbine海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%