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甲麦角林

甲麦角林用途

Metergoline是一种麦角灵化学类的精神药物，常用作各种血清素和多巴胺受体的配体。

甲麦角林名称

[ CAS 号 ]:
17692-51-2

[ 中文名 ]:
甲麦角林

[ 英文名 ]:
Metergoline

[中文别名 ]:

美塔可宁

[英文别名 ]:

EINECS 241-686-3
MFCD00153829

甲麦角林生物活性

[ 描述 ]:

Metergoline是一种麦角灵化学类的精神药物,常用作各种血清素和多巴胺受体的配体。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 5-HT受体

信号通路 >> 神经信号通路 >> 5-HT受体

研究领域 >> 神经疾病

[相关活性小分子]

甲麦角林物理化学性质

[ 密度 ]:
1.25g/cm3

[ 沸点 ]:
612.5ºC at 760mmHg

[ 熔点 ]:
148-150 °C(lit.)

[ 分子式 ]:
C₂₅H₂₉N₃O₂

[ 分子量 ]:
403.51700

[ 闪点 ]:
324.2ºC

[ 精确质量 ]:
403.22600

[ PSA ]:
46.50000

[ LogP ]:
4.39350

[ 蒸汽压 ]:
0mmHg at 25°C

[ 储存条件 ]:
−20°C

[ 水溶解性 ]:
0.1 M HCl: 1.4 mg/mL

甲麦角林MSDS

详细MSDS(安全技术说明书)

甲麦角林毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: FA1070000

CHEMICAL NAME :: Carbamic acid, (((8-beta)-1,6-dimethylergolin-8-yl)methyl)-, benzyl ester

CAS REGISTRY NUMBER :: 17692-51-2

LAST UPDATED :: 199703

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C25-H29-N3-O2

MOLECULAR WEIGHT :: 403.57

WISWESSER LINE NOTATION :: T C6656 1A P GN LNTT&&J E1MVO1R& G1 L1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 430 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869- Volume(issue)/page/year: 207,421,1965

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 85 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869- Volume(issue)/page/year: 207,421,1965

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 21200 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4176182

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 20 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869- Volume(issue)/page/year: 207,421,1965 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1200 ug/kg

SEX/DURATION :: lactating female 5 day(s) post-birth

TOXIC EFFECTS :: Reproductive - Maternal Effects - postpartum Reproductive - Maternal Effects - other effects

REFERENCE :: OBGNAS Obstetrics and Gynecology. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1953- Volume(issue)/page/year: 51,113,1978

甲麦角林安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H312-H332

[ 警示性声明 ]:
P280

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
R20/21/22

[ 安全声明 (欧洲) ]:
S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
FA1070000

甲麦角林文献

5-HT receptor subtypes as key targets in mediating pigment dispersion within melanophores of teleost, Oreochromis mossambicus.

Comp. Biochem. Physiol. B Biochem. Mol. Biol. 164(2) , 117-23, (2013)

The presence of distinct class of 5-HT receptors in the melanophores of tilapia (Oreochromis mossambicus) is reported. The cellular responses to 5-HT (5-hydroxytryptamine), 5-HT(1), and 5-HT(2), agoni...

Suppression of transcriptional drift extends C. elegans lifespan by postponing the onset of mortality.

Elife 4 , (2015)

Longevity mechanisms increase lifespan by counteracting the effects of aging. However, whether longevity mechanisms counteract the effects of aging continually throughout life, or whether they act dur...

Pharmacological characterisation of the thermogenic effect of bupropion.

Eur. J. Pharmacol. 498(1-3) , 219-25, (2004)

The pharmacological mechanism of bupropion's thermogenic effect has been investigated in female Wistar rats by measuring oxygen consumption at thermoneutrality (29 degrees C). Bupropion (30 mg/kg) rap...

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