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消草磺灵

消草磺灵用途

米扎林是一种二硝基苯胺类除草剂,与植物微管蛋白结合并在体外抑制微管聚合。米扎林解聚MTs并阻止新MTs在有丝分裂周期的所有阶段聚合[1]。

消草磺灵名称

[ CAS 号 ]:
19044-88-3

[ 中文名 ]:
氨磺乐灵

[ 英文名 ]:
Oryzalin

[中文别名 ]:

安磺灵

[英文别名 ]:

4-(dipropylamino)-3,5-dinitrobenzene-1-sulfonamide
Surflan
Caswell No. 623A
4-(dipropylamino)-3,5-dinitrobenzenesulfonamide
Ryzelan
MFCD00078725
3,5-dinitro-N4,N4-dipropylsulfanilamide
Dirimal
ORYZALIN
3,5-Dinitro-4-dipropylamino-benzenesulphonamide

消草磺灵生物活性

[ 描述 ]:

米扎林是一种二硝基苯胺类除草剂,与植物微管蛋白结合并在体外抑制微管聚合。米扎林解聚MTs并阻止新MTs在有丝分裂周期的所有阶段聚合[1]。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 细胞周期/DNA损伤 >> 微管/微管蛋白

信号通路 >> 细胞骨架 >> 微管/微管蛋白

[参考文献]

[1]. Morejohn LC, et al. Oryzalin, a dinitroaniline herbicide, binds to plant tubulin and inhibits microtubule polymerization in vitro. Planta. 1987 Oct;172(2):252-64.

消草磺灵物理化学性质

[ 密度 ]:
1.2

[ 沸点 ]:
514ºC at 760mmHg

[ 熔点 ]:
141°C

[ 分子式 ]:
C₁₂H₁₈N₄O₆S

[ 分子量 ]:
346.36000

[ 闪点 ]:
264.6ºC

[ 精确质量 ]:
346.09500

[ PSA ]:
163.42000

[ LogP ]:
4.60430

[ 外观性状 ]:
黄色-橙色晶体

[ 蒸汽压 ]:
1.13E-10mmHg at 25°C

[ 折射率 ]:
1.588

[ 储存条件 ]:
库房通风低温干燥,与食品原料分开储运

消草磺灵MSDS

消草磺灵毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WO9350000

CHEMICAL NAME :: Sulfanilamide, 3,5-dinitro-N(sup 4),N(sup 4)-dipropyl-

CAS REGISTRY NUMBER :: 19044-88-3

LAST UPDATED :: 199710

DATA ITEMS CITED :: 11

MOLECULAR FORMULA :: C12-H18-N4-O6-S

MOLECULAR WEIGHT :: 346.40

WISWESSER LINE NOTATION :: ZSWR CNW ENW DN3&3

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 10000 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - chicken

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - gerbil

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 300 ug/plate

REFERENCE :: KHFKDF K'o Hsueh Fa Chan Yueh K'an. Progress in Sciences. (Kuo Chia K'o Hsueh Wei Yuan Hui, 2 Canton St., Taipei 107, Taiwan) V.1- 1973- Volume(issue)/page/year: 8,551,1980 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989

消草磺灵安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves

[ 危害码 (欧洲) ]:
N:Dangerousfortheenvironment;

[ 风险声明 (欧洲) ]:
R51/53

[ 安全声明 (欧洲) ]:
S60

[ 危险品运输编码 ]:
UN 3077

[ RTECS号 ]:
WO9350000

[ 海关编码 ]:
2935009017

消草磺灵合成路线

消草磺灵海关

[ 海关编码 ]: 2935009017

[ 中文概述 ]:
2935009017 磺草膦,氨磺乐灵,三氟啶磺隆,啶磺草胺等〔包括甲基碘磺隆钠盐〕。监管条件:S(进出口农药登记证明)。增值税率:17.0%。退税率:9.0%。最低关税:6.5%。普通关税:35.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ 监管条件 ]: S.进出口农药登记证明

[ Summary ]:
2935009017 4-(dipropylamino)-3,5-dinitrobenzenesulfonamide。supervision conditions:s(import or export registration certificate for pesticides)。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:6.5%。general tariff:35.0%

消草磺灵文献

Salt stress-induced disassembly of Arabidopsis cortical microtubule arrays involves 26S proteasome-dependent degradation of SPIRAL1.

Plant Cell 23(9) , 3412-27, (2011)

The dynamic instability of cortical microtubules (MTs) (i.e., their ability to rapidly alternate between phases of growth and shrinkage) plays an essential role in plant growth and development. In add...

Arabidopsis dynamin-related proteins, DRP2A and DRP2B, function coordinately in post-Golgi trafficking.

Biochem. Biophys. Res. Commun. 456(1) , 238-44, (2015)

Dynamin-related proteins (DRPs) are large GTPases involved in a wide range of cellular membrane remodeling processes. In Arabidopsis thaliana, two paralogous land plant-specific type DRPs, DRP2A and D...

Microtubules Are Essential for Guard-Cell Function in Vicia and Arabidopsis

Mol. Plant 5(3) , 601-10, (2012)

Radially arranged cortical microtubules are a prominent feature of guard cells. Guard cells expressing GFP-tubulin showed consistent changes in the appearance of microtubules when stomata opened or cl...

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