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SC 19220

SC 19220用途

SC-19220是一种竞争性前列腺素E2受体拮抗剂。SC-19220增加了氨基甲酸乙酯麻醉大鼠的膀胱容量,降低了排尿效率(由缓慢经膀胱充盈引起)。SC-19220可以恢复烧伤脓毒症后骨髓粒细胞和单核细胞生成的平衡[1][2]。

SC 19220名称

[ CAS 号 ]:
19395-87-0

[ 英文名 ]:
SC 19220

[英文别名 ]:

Lopac-S-3065
N,N-Dimethylsphingosine
Tocris-1206

SC 19220生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 前列腺素受体

[ 靶点 ]

PGE2[1]

[参考文献]

[1]. Maggi CA, et al. The effect of SC-19220, a prostaglandin antagonist, on the micturition reflex in rats. Eur J Pharmacol. 1988 Aug 2;152(3):273-9.

[2]. Santangelo S, Shoup M, Gamelli RL, Shankar R. Prostaglandin E2 receptor antagonist (SC-19220) treatment restores the balance to bone marrow myelopoiesis after burn sepsis. J Trauma. 2000 May;48(5):826-30; discussion 830-1.

SC 19220物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 分子式 ]:
C₁₆H₁₄ClN₃O₃

[ 分子量 ]:
331.754

[ 精确质量 ]:
331.072357

[ PSA ]:
70.67000

[ LogP ]:
2.20

[ 折射率 ]:
1.624

[ 储存条件 ]:
-20°C，密闭，干燥

SC 19220MSDS

详细MSDS(安全技术说明书)

SC 19220安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

SC 19220文献

The role of prostaglandin E and thromboxane-prostanoid receptors in the response to prostaglandin E2 in the aorta of Wistar Kyoto rats and spontaneously hypertensive rats.

Cardiovasc. Res. 78(1) , 130-8, (2008)

The present study examined the hypothesis that prostaglandin E2 (PGE2) through activation of prostaglandin E (EP) receptor contributes to endothelium-dependent contractions.Western blotting revealed t...

Prostanoid receptors involved in regulation of the beating rate of neonatal rat cardiomyocytes.

PLoS ONE 7(9) , e45273, (2012)

Although prostanoids are known to be involved in regulation of the spontaneous beating rate of cultured neonatal rat cardiomyocytes, the various subtypes of prostanoid receptors have not been investig...

Prostaglandin E₂ possesses different potencies in inducing Vascular Endothelial Growth Factor and Interleukin-8 production in COPD human lung fibroblasts.

Prostaglandins Leukot. Essent. Fatty Acids 106 , 11-Aug, (2016)

We studied the role of PGE2, its biosynthetic enzymes and its receptors, in regulating the functions of lung fibroblasts through the production of Vascular Endothelial Growth Factor (VEGF) and Interle...

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