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5-羟基吲哚

5-羟基吲哚用途

5-羟基吲哚是一种羟基化吲哚,广泛存在于各种药理活性剂和天然产物中。5-羟基吲哚减缓N1E-115神经母细胞瘤细胞中5-HT3受体介导的离子电流的脱敏[1][2]。

5-羟基吲哚名称

[ CAS 号 ]:
1953-54-4

[ 中文名 ]:
5-羟基吲哚

[ 英文名 ]:
5-Indolol

[中文别名 ]:

[英文别名 ]:

5-hydroxyindol
5-Hydroxyindole,5-Indolol
5-hydroxy-1H-indol
EINECS 217-782-6
1H-Indol-5-ol
5-Hydroxy-1H-indole
INDOL-5-OL
1H-indole-5-ol
Hydroxy-5-indole
5-Indolol

5-羟基吲哚生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Kooyman AR, et, al. 5-Hydroxyindole slows desensitization of the 5-HT3 receptor-mediated ion current in N1E-115 neuroblastoma cells. Br J Pharmacol. 1993 Feb;108(2):287-9.

[2]. LaPorte M, et, al. 5-Hydroxyindoles by intramolecular alkynol-furan diels-alder cycloaddition. J Org Chem. 2013 Jan 4;78(1):167-74.

5-羟基吲哚物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
343.2±15.0 °C at 760 mmHg

[ 熔点 ]:
105-110ºC

[ 分子式 ]:
C₈H₇NO

[ 分子量 ]:
133.147

[ 闪点 ]:
161.4±20.4 °C

[ 精确质量 ]:
133.052765

[ PSA ]:
36.02000

[ LogP ]:
0.97

[ 外观性状 ]:
灰白色结晶粉末

[ 蒸汽压 ]:
0.0±0.8 mmHg at 25°C

[ 折射率 ]:
1.739

[ 储存条件 ]:
0-6°C

5-羟基吲哚MSDS

5-羟基吲哚毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NM2430000

CHEMICAL NAME :: Indol-5-ol

CAS REGISTRY NUMBER :: 1953-54-4

BEILSTEIN REFERENCE NO. :: 0112349

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C8-H7-N-O

MOLECULAR WEIGHT :: 133.16

WISWESSER LINE NOTATION :: T56 BMJ GQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique. (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France) V.9- 1974- Volume(issue)/page/year: 9,453,1974

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 56 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#01920

5-羟基吲哚安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S37/39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
NM2430000

[ 海关编码 ]:
29339990

5-羟基吲哚合成路线

5-羟基吲哚上下游产品

5-羟基吲哚上游产品

5-羟基吲哚下游产品

5-羟基吲哚海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

5-羟基吲哚文献

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Forensic Sci. Int. 243 , 117-25, (2014)

An UPLC-MS/MS method using ESI+ionization and MRM was developed and fully validated according to international guidelines for the qualitative and quantitative analysis of nine synthetic cannabinoids a...

A separation of tyramine on a 2-(4-methoxyphenyl)ethylamine imprinted polymer: an answer from theoretical and experimental studies.

Talanta 129 , 155-64, (2014)

A 2-(4-methoxyphenyl)ethylamine imprinted polymer (MIP) was successfully applied for the selective separation of tyramine. A computational analysis was used to predict the affinity of the polymer matr...

Determination of selected synthetic cannabinoids and their metabolites by micellar electrokinetic chromatography--mass spectrometry employing perfluoroheptanoic acid-based micellar phase.

Talanta 150 , 568-76, (2016)

Perfluoroheptanoic acid was employed as a volatile micellar phase in background electrolyte for micellar electrokinetic chromatography-tandem mass spectrometry separation and determination of 15 selec...

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