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5-羟基吲哚-3-乙酸

5-羟基吲哚-3-乙酸用途

5-Hydroxyindole-3-acetic acid 是 5-羟色胺或甲氧基肾上腺素的主要代谢产物,被用作神经内分泌肿瘤的生物标志物。

5-羟基吲哚-3-乙酸名称

[ CAS 号 ]:
54-16-0

[ 中文名 ]:
5-羟基吲哚-3-乙酸

[ 英文名 ]:
5-Hydroxyindole-3-acetic acid

[中文别名 ]:

[英文别名 ]:

5-Hydroxyindoleacetic acid
(5-Hydroxy-1H-indol-3-yl)acetic acid
2-(5-Hydroxy-1H-indol-3-yl)acetic acid
(5-hydroxyindol-3-yl)acetic acid
5-hydroxy-indole-3-acetic acid
EINECS 200-195-4
MFCD00005639
5-Hydroxyindoleacetate
5-Hydroxyindole-3-acetic Acid
1H-Indole-3-acetic acid, 5-hydroxy-

5-羟基吲哚-3-乙酸生物活性

[ 描述 ]:

5-Hydroxyindole-3-acetic acid 是 5-羟色胺或甲氧基肾上腺素的主要代谢产物,被用作神经内分泌肿瘤的生物标志物。

[ 相关类别 ]:

研究领域 >> 神经疾病

天然产物 >> 酸和醛

研究领域 >> 癌症

[ 靶点 ]

Human Endogenous Metabolite

[体外研究]

5-羟基吲哚-3-乙酸(5HIAA)是由5-羟色胺代谢产生的代谢产物,后者由必需氨基酸色氨酸合成。 5-羟色胺主要通过肝脏和肺部的单胺氧化酶代谢[1]。

[参考文献]

[1]. Corcuff JB, et al. Urinary sampling for 5HIAA and metanephrines determination: revisiting the recommendations. Endocr Connect. 2017 Aug;6(6):R87-R98.

[相关活性小分子]

5-羟基吲哚-3-乙酸物理化学性质

[ 密度 ]:
1.496±0.06 g/cm3

[ 沸点 ]:
497.1±30.0 °C at 760 mmHg

[ 熔点 ]:
161-164ºC (dec.)(lit.)

[ 分子式 ]:
C₁₀H₉NO₃

[ 分子量 ]:
191.183

[ 闪点 ]:
254.4±24.6 °C

[ 精确质量 ]:
191.058243

[ PSA ]:
73.32000

[ LogP ]:
0.26

[ 外观性状 ]:
固体;White to Amber to Dark purple powder to crystal

[ 蒸汽压 ]:
0.0±1.3 mmHg at 25°C

[ 折射率 ]:
1.740

[ 储存条件 ]:
存放于惰性气体之中;避免光,空气

[ 水溶解性 ]:
Sparingly soluble (11 g/L) (25 ºC)

5-羟基吲哚-3-乙酸MSDS

5-羟基吲哚-3-乙酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NL3650000

CHEMICAL NAME :: 1H-Indole-3-acetic acid, 5-hydroxy-

CAS REGISTRY NUMBER :: 54-16-0

BEILSTEIN REFERENCE NO. :: 0168797

LAST UPDATED :: 199709

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C10-H9-N-O3

MOLECULAR WEIGHT :: 191.20

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1125 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity)

REFERENCE :: JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76- Volume(issue)/page/year: 1,515,1976 ** TUMORIGENIC DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2000 mg/kg/20W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumor types after systemic administration not seen spontaneously

REFERENCE :: AICCA6 Acta Unio Internationalis Contra Cancrum. (Louvain, Belgium) V.1-20, 1936-64. For publisher information, see IJCNAW. Volume(issue)/page/year: 19,660,1963

5-羟基吲哚-3-乙酸安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 安全声明 (欧洲) ]:
S22;S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
NL3650000

[ 海关编码 ]:
2933990090

5-羟基吲哚-3-乙酸合成路线

5-羟基吲哚-3-乙酸上下游产品

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5-羟基吲哚-3-乙酸海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

5-羟基吲哚-3-乙酸文献

Permeation of Dopamine Sulfate through the Blood-Brain Barrier.

PLoS ONE 10 , e0133904, (2015)

Dopamine sulfate (DA-3- and DA-4-S) have been determined in the human brain, but it is unclear whether they are locally formed in the central nervous system (CNS), or transported into the CNS from per...

Chemical genetics reveals a complex functional ground state of neural stem cells.

Nat. Chem. Biol. 3(5) , 268-273, (2007)

The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain canc...

The urinary ratio of 3-hydroxykynurenine/3-hydroxyanthranilic acid is an index to predicting the adverse effects of D-tryptophan in rats.

J. Nutr. Sci. Vitaminol. 60(4) , 261-8, (2014)

The adverse effects of D-tryptophan and the possibility of it being a surrogate index for predicting adverse effects in rats were investigated. Male rats were fed one of several test diets (20% casein...

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