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4-氨基-4-脱氧-10-甲基蝶酸

4-氨基-4-脱氧-10-甲基蝶酸用途

Methotrexate metabolite (DAMPA),是 Methotrexate 的活性代谢产物。 Methotrexate 是一种叶酸 (folic acid) 拮抗剂,广泛用作免疫抑制剂和化学治疗剂。

4-氨基-4-脱氧-10-甲基蝶酸名称

[ CAS 号 ]:
19741-14-1

[ 中文名 ]:
4-[N-(2,4-二氨基-6-蝶啶甲基)-N-甲氨基]苯甲酸半盐酸盐n水

[ 英文名 ]:
4-Amino-4-deoxy-10-methylpteroic acid

[中文别名 ]:

[英文别名 ]:

Methotrexate impurity E
S1584_Selleck
Deoxyaminopteroic acid
DAMPA
4-Amino-4-deoxy-10-methylpteroic acid
Methotrexate Impurity 5

4-氨基-4-脱氧-10-甲基蝶酸生物活性

[ 描述 ]:

Methotrexate metabolite (DAMPA),是 Methotrexate 的活性代谢产物。 Methotrexate 是一种叶酸 (folic acid) 拮抗剂,广泛用作免疫抑制剂和化学治疗剂。

[ 相关类别 ]:

信号通路 >> 细胞周期/DNA损伤 >> 叶酸

研究领域 >> 炎症/免疫

[参考文献]

[1]. Schofield RC, et al. Development and validation of a turbulent flow chromatography and tandem mass spectrometry method for the quantitation of methotrexate and its metabolites 7-hydroxy methotrexate and DAMPA in serum. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Oct 1;1002:169-75.

4-氨基-4-脱氧-10-甲基蝶酸物理化学性质

[ 密度 ]:
1.532

[ 沸点 ]:
689.3±65.0 °C at 760 mmHg

[ 熔点 ]:
242 ºC

[ 分子式 ]:
C₁₅H₁₅N₇O₂

[ 分子量 ]:
325.325

[ 闪点 ]:
370.7±34.3 °C

[ 精确质量 ]:
325.128723

[ PSA ]:
144.14000

[ LogP ]:
1.75

[ 蒸汽压 ]:
0.0±2.3 mmHg at 25°C

[ 折射率 ]:
1.799

[ 储存条件 ]:
2-8°C

4-氨基-4-脱氧-10-甲基蝶酸安全信息

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
43-52/53

[ 安全声明 (欧洲) ]:
36/37

[ WGK德国 ]:
3

[ 海关编码 ]:
2933990090

4-氨基-4-脱氧-10-甲基蝶酸海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

4-氨基-4-脱氧-10-甲基蝶酸文献

Chemically induced dimerization of dihydrofolate reductase by a homobifunctional dimer of methotrexate.

Chem. Biol. 7(5) , 313-21, (2000)

Chemically induced dimerization (CID) can be used to manipulate cellular regulatory pathways from signal transduction to transcription, and to create model systems for study of the specific interactio...

An investigation into the source of the deglutamated metabolites of methotrexate in patients treated with high dose infusions.

Ann. Clin. Biochem. 23 ( Pt 2) , 210-5, (1986)

The influence of 7-OH methotrexate metabolite on clinical relevance of methotrexate determination.

Clin. Lab. 57(7-8) , 599-606, (2011)

A modified high performance liquid chromatographic (HPLC) method has been developed for the simultaneous determination of methotrexate (MTX) and its main metabolite 7-hydroxymethotrexate (7-OHMTX) and...

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