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抗霉素

抗霉素用途

抵抗素是一种五环聚酮类抗生素,具有抗癌活性并诱导细胞凋亡[1][2][3][4]。

抗霉素名称

[ CAS 号 ]:
20004-62-0

[ 中文名 ]:
抗霉素

[ 英文名 ]:
Resistomycin

[英文别名 ]:

A 3733A
Itamycin
Geliomycin
Antibiotic A 3733a
Croceomycin

抗霉素生物活性

[ 描述 ]:

抵抗素是一种五环聚酮类抗生素,具有抗癌活性并诱导细胞凋亡[1][2][3][4]。

[ 相关类别 ]:

信号通路 >> 细胞凋亡 >> 细胞凋亡

研究领域 >> 癌症

信号通路 >> 抗感染 >> 细菌

[体外研究]

抵抗素通过抑制E3连接酶Pellino-1和诱导蜗牛/蛞蝓降解来减轻三重阴性乳腺癌的进展[1]。如表面等离子体共振所示,抵抗霉素对GST-Pellino-1(KD=2.58μM)具有高度亲和力[1]。抵抗素处理降低TNBC细胞中蜗牛和蛞蝓的表达[1]。抵抗素通过激活p38 MAPK通路在体内外诱导人肝癌细胞凋亡和周期阻滞[3]。

抗霉素物理化学性质

[ 分子式 ]:
C₂₂H₁₆O₆

[ 分子量 ]:
376.35900

[ 精确质量 ]:
376.09500

[ PSA ]:
115.06000

[ LogP ]:
3.65590

[ 储存条件 ]:
-20°C，密闭，干燥

抗霉素毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DJ6350000

CHEMICAL NAME :: 2H-Benzo(cd)pyrene-2,6(1H)-dione, 3,5,7,10-tetrahydroxy-1,1,9-trimethyl-

CAS REGISTRY NUMBER :: 20004-62-0

BEILSTEIN REFERENCE NO. :: 2187224

LAST UPDATED :: 199707

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C22-H16-O6

MOLECULAR WEIGHT :: 376.38

WISWESSER LINE NOTATION :: L C6666 B6 3ABC S GV IV RHJ EQ KQ M1 OQ R1 R1 SQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 3,354,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 20 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 3,351,1980 ** TUMORIGENIC DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Implant

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 20750 ug/kg

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors Tumorigenic - tumors at site of application

REFERENCE :: JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC) V.61-79, 1978-87. For publisher information, see JNCIEQ. Volume(issue)/page/year: 71,539,1983

抗霉素安全信息

[ 海关编码 ]:
2914400090

抗霉素合成路线

详细合成路线

抗霉素海关

[ 海关编码 ]: 2914400090

[ 中文概述 ]:
2914400090 其他酮醇及酮醛。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:5.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 丙酮报明包装

[ Summary ]:
2914400090 other ketone-alcohols and ketone-aldehydes。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

抗霉素