抗霉素A

抗霉素A用途

Antimycin A3 是从多种链霉菌中分离出来的抗生素,具有抗真菌活性。Antimycin A3 是有效的呼吸 (respiration) 抑制剂。Antimycin A3 抑制泛醇-细胞色素 c 氧化还原酶 (ubiquinol-cytochrome c oxidoreductase) 的电子转移活性,并阻止人类癌细胞的生长。Antimycin A3 也抑制 ATP 柠檬酸裂解酶,Ki 值为 60.1 µM。

抗霉素A名称

[ CAS 号 ]:
522-70-3

[ 中文名 ]:
抗霉素A

[ 英文名 ]:
Antimycin A3

[英文别名 ]:

antimycina3
ioxonan-3-yl)-3-formamidosalicylamide,stereoisomer
Blastmycin

抗霉素A生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 癌症

研究领域 >> 感染

[体外研究]

抗霉素A3通过选择性杀伤表达高水平抗凋亡Bcl-2和Bcl-XL的癌细胞而诱导癌细胞凋亡[1]。

[参考文献]

[1]. Ade Arsianti, et al. Synthesis and anticancer activity of polyhydroxylated 18-membered analogue of antimycin A3. Tetrahedron.Volume 68, Issue 13, 1 April 2012, Pages 2884-2891.

[2]. Miyoshi H, et al. Inhibition of electron transport of rat liver mitochondria by unnatural (-)-antimycin A3.

[3]. Barrow CJ, et al. Antimycins, inhibitors of ATP-citrate lyase, from a Streptomyces sp. J Antibiot (Tokyo). 1997 Sep;50(9):729-33.

抗霉素A物理化学性质

[ 密度 ]:
1.25g/cm3

[ 沸点 ]:
745.5ºC at 760mmHg

[ 分子式 ]:
C₂₆H₃₆N₂O₉

[ 分子量 ]:
520.57200

[ 闪点 ]:
404.7ºC

[ 精确质量 ]:
520.24200

[ PSA ]:
157.33000

[ LogP ]:
3.80000

[ 折射率 ]:
1.549

[ 储存条件 ]:
库房通风低温干燥,与食品原料分开储运

抗霉素A毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NY1502900

CHEMICAL NAME :: Isovaleric acid, N-ester with N-(7-butyl-8-hydroxy-4,9-dimethyl-2,6-dioxo-1,5-dioxo nan-3-yl) -3-formamidosalicylamide, stereoisomer

CAS REGISTRY NUMBER :: 522-70-3

LAST UPDATED :: 199709

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C26-H36-N2-O9

MOLECULAR WEIGHT :: 520.64

WISWESSER LINE NOTATION :: T9OV EOVTJ CMVR BQ CMVH& D1 G4 HOV1Y1&1 I1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1800 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JAJAAA Journal of Antibiotics, Series A. (Tokyo, Japan) V.6-20, 1953-67. For publisher information, see JANTAJ. Volume(issue)/page/year: 10,39,1957

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1600 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JAJAAA Journal of Antibiotics, Series A. (Tokyo, Japan) V.6-20, 1953-67. For publisher information, see JANTAJ. Volume(issue)/page/year: 10,39,1957

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 900 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85FZAT "Index of Antibiotics from Actinomycetes," Umezawa, H. et al., eds., Tokyo, Univ. of Tokyo Press, 1967 Volume(issue)/page/year: -,145,1967

抗霉素A安全信息

[ 风险声明 (欧洲) ]:
23/24/25

[ 危险品运输编码 ]:
UN 3172

[ WGK德国 ]:
2

[ RTECS号 ]:
EB3140000

[ 包装等级 ]:
II

[ 危险类别 ]:
6.1(a)