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花椒毒酚,花椒毒醇

花椒毒酚,花椒毒醇用途

Xanthotoxol 是一种具有生物活性的线性呋喃香豆素,有强烈的药理学活性,如抗炎,抗氧化,5-HT 拮抗和神经保护作用。

花椒毒酚,花椒毒醇名称

[ CAS 号 ]:
2009-24-7

[ 中文名 ]:
花椒毒醇

[ 英文名 ]:
Xanthotoxol

[中文别名 ]:

[英文别名 ]:

9-hydroxyfuro[3,2-g]chromen-7-one
8-Hydroxypsoralen
T C566 DO LVOJ BQ
8-Hydroxy-4':5',6:7-furocoumarin
7H-Furo[3,2-g][1]benzopyran-7-one, 9-hydroxy-
9-Hydroxy-7H-furo[3,2-g]chromen-7-one
Xanthotoxol
EINECS 217-923-1

花椒毒酚,花椒毒醇生物活性

[ 描述 ]:

Xanthotoxol 是一种具有生物活性的线性呋喃香豆素,有强烈的药理学活性,如抗炎,抗氧化,5-HT 拮抗和神经保护作用。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 5-HT受体

信号通路 >> 神经信号通路 >> 5-HT受体

天然产物 >> 苯丙酸类

研究领域 >> 炎症/免疫

研究领域 >> 神经疾病

[ 靶点 ]

5-HT[1]

[参考文献]

[1]. Ma Z, et al. Metabolism and Metabolic Inhibition of Xanthotoxol in Human Liver Microsomes. Evid Based Complement Alternat Med. 2016;2016:5416509.

[相关活性小分子]

花椒毒酚,花椒毒醇物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 沸点 ]:
428.1±45.0 °C at 760 mmHg

[ 熔点 ]:
250ºC

[ 分子式 ]:
C₁₁H₆O₄

[ 分子量 ]:
202.163

[ 闪点 ]:
212.7±28.7 °C

[ 精确质量 ]:
202.026611

[ PSA ]:
63.58000

[ LogP ]:
0.72

[ 蒸汽压 ]:
0.0±1.1 mmHg at 25°C

[ 折射率 ]:
1.711

[ 储存条件 ]:
-20°C

花椒毒酚,花椒毒醇毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LV1069000

CHEMICAL NAME :: 7H-Furo(3,2-g)(1)benzopyran-7-one, 9-hydroxy-

CAS REGISTRY NUMBER :: 2009-24-7

BEILSTEIN REFERENCE NO. :: 0189491

LAST UPDATED :: 199612

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C11-H6-O4

MOLECULAR WEIGHT :: 202.17

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 480 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JOETD7 Journal of Ethnopharmacology. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1979- Volume(issue)/page/year: 36,239,1992

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JOETD7 Journal of Ethnopharmacology. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1979- Volume(issue)/page/year: 36,239,1992

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 468 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JOETD7 Journal of Ethnopharmacology. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1979- Volume(issue)/page/year: 36,239,1992

花椒毒酚,花椒毒醇安全信息

[ 风险声明 (欧洲) ]:
25

[ 安全声明 (欧洲) ]:
20-45

[ 危险品运输编码 ]:
UN 2810

[ 海关编码 ]:
2932999099

花椒毒酚,花椒毒醇合成路线

详细合成路线

花椒毒酚,花椒毒醇上下游产品

花椒毒酚,花椒毒醇上游产品

花椒毒酚,花椒毒醇下游产品

花椒毒酚,花椒毒醇海关

[ 海关编码 ]: 2932999099

[ 中文概述 ]:
2932999099. 其他仅含氧杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%