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N-(2-氨基-2-氧代乙基)-N-(羧甲基)甘氨酸

N-(2-氨基-2-氧代乙基)-N-(羧甲基)甘氨酸用途

Tubulysin A(TubA)是黏液性细菌的产物,体外具有抗血管生成、抗有丝分裂、抗增殖的作用。

N-(2-氨基-2-氧代乙基)-N-(羧甲基)甘氨酸名称

[ CAS 号 ]:
205304-86-5

[ 中文名 ]:
N-(2-氨基-2-氧代乙基)-N-(羧甲基)甘氨酸

[ 英文名 ]:
Tubulysin A

[英文别名 ]:

TubA
Tubulysin A

N-(2-氨基-2-氧代乙基)-N-(羧甲基)甘氨酸生物活性

[ 描述 ]:

Tubulysin A(TubA)是黏液性细菌的产物,体外具有抗血管生成、抗有丝分裂、抗增殖的作用。

[ 相关类别 ]:

信号通路 >> 抗体- 药物偶联物 >> ADC细胞毒素

信号通路 >> 细胞周期/DNA损伤 >> 微管/微管蛋白

信号通路 >> 细胞骨架 >> 微管/微管蛋白

研究领域 >> 癌症

[参考文献]

[1]. Kaur G, et al. Biological evaluation of tubulysin A: a potential anticancer and antiangiogenic natural product. Biochem J. 2006 Jun 1;396(2):235-42.

[2]. Sasse F, et al. Tubulysins, new cytostatic peptides from myxobacteria acting on microtubuli. Production, isolation, physico-chemical and biological properties. J Antibiot (Tokyo). 2000 Sep;53(9):879-85.

[3]. Khalil MW, et al. Mechanism of action of tubulysin, an antimitotic peptide from myxobacteria. Chembiochem. 2006 Apr;7(4):678-83.

[相关活性小分子]

N-(2-氨基-2-氧代乙基)-N-(羧甲基)甘氨酸物理化学性质

[ 分子式 ]:
C₄₃H₆₅N₅O₁₀S

[ 分子量 ]:
844.06900

[ 精确质量 ]:
843.44500

[ PSA ]:
239.99000

[ LogP ]:
7.06310

[ 外观性状 ]:
colorless or white

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
organic solvents: soluble

N-(2-氨基-2-氧代乙基)-N-(羧甲基)甘氨酸安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301-H311-H315-H319-H331-H335

[ 警示性声明 ]:
P261-P280-P301 + P310-P305 + P351 + P338-P311

[ 个人防护装备 ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T

[ 风险声明 (欧洲) ]:
23/24/25-36/37/38

[ 安全声明 (欧洲) ]:
36/37-45

[ 危险品运输编码 ]:
UN 2811 6.1 / PGIII

N-(2-氨基-2-氧代乙基)-N-(羧甲基)甘氨酸文献

A complex of ZO-1 and the BAR-domain protein TOCA-1 regulates actin assembly at the tight junction.

Mol. Biol. Cell 26 , 2769-87, (2015)

Assembly and sealing of the tight junction barrier are critically dependent on the perijunctional actin cytoskeleton, yet little is known about physical and functional links between barrier-forming pr...

Biological evaluation of tubulysin A: a potential anticancer and antiangiogenic natural product.

Biochem. J. 396 , 235-242, (2006)

Tubulysin A (tubA) is a natural product isolated from a strain of myxobacteria that has been shown to depolymerize microtubules and induce mitotic arrest. The potential of tubA as an anticancer and an...

An antibody to de-N-acetyl sialic acid containing-polysialic acid identifies an intracellular antigen and induces apoptosis in human cancer cell lines.

PLoS ONE 6 , e27249, (2011)

Polysialic acid (PSA), an α2,8-linked homopolymer of N-acetylneuraminic acid (Neu5Ac), is developmentally regulated and its expression is thought to be restricted to a few tissues in adults. Recently,...

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