α-卡茄碱

α-卡茄碱用途

α-Chaconine,从Solanum tuberosum L. cv Jayoung 分离的,可在转录水平抑制 COX-2,IL-1β,IL-6 和 TNF-α 表达。α-Chaconine 作用于 RAW 264.7 巨噬细胞,在蛋白和 mRNA 水平上抑制 LPS 诱导的 iNOS 和 COX-2 表达及其启动子活性。α-Chaconine 具有抗炎作用。

α-卡茄碱名称

[ CAS 号 ]:
20562-03-2

[ 中文名 ]:
卡茄碱

[ 英文名 ]:
alpha-Chaconine

[英文别名 ]:

chaconine
chaconine,a
a-chaconine with tlc
a-chaconine
a-chaconine from potato sprouts
alpa-chaconine

α-卡茄碱生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 炎症/免疫

信号通路 >> 免疫及炎症 >> COX

[ 靶点 ]

COX-2

[体外研究]

α-查康宁通过减少c-jun的易位和磷酸化来减弱激活蛋白-1(AP-1)的转录活性。α-查康碱通过脂多糖诱导的264.7巨噬细胞中的AP-1失活抑制脂多糖诱导的炎症介质,并保护小鼠免受内毒素休克。α- Chaconine也抑制了位于MKK7/JNK信号上游的TGF-β激活激酶-1(TAK1)的磷酸化[1]。

[参考文献]

[1]. Lee KG, et al. α-Chaconine isolated from a Solanum tuberosum L. cv Jayoung suppresses lipopolysaccharide-induced pro-inflammatory mediators via AP-1 inactivation in RAW 264.7 macrophages and protects mice from endotoxin shock. Chem Biol Interact. 2015 Jun 25;235:85-94.

α-卡茄碱物理化学性质

[ 密度 ]:
1.37 g/cm3

[ 熔点 ]:
228-236ºC

[ 分子式 ]:
C₄₅H₇₃NO₁₄

[ 分子量 ]:
852.05900

[ 精确质量 ]:
851.50300

[ PSA ]:
220.46000

[ LogP ]:
1.12070

[ 折射率 ]:
1.621

[ 储存条件 ]:
库房低温通风干燥,与食品原料分开存放

[ 水溶解性 ]:
pyridine: 10 mg/mL, clear, very faintly yellow

α-卡茄碱毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: FL6700000

CHEMICAL NAME :: alpha-Chaconine

CAS REGISTRY NUMBER :: 20562-03-2

BEILSTEIN REFERENCE NO. :: 0077396

LAST UPDATED :: 199612

DATA ITEMS CITED :: 10

MOLECULAR FORMULA :: C45-H73-N-O14

MOLECULAR WEIGHT :: 852.19

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 84 mg/kg

TOXIC EFFECTS :: Blood - hemorrhage

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 19 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - cyanosis

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 160 mg/kg/8D-I

TOXIC EFFECTS :: Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 80 mg/kg/2D-I

TOXIC EFFECTS :: Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 40 mg/kg

SEX/DURATION :: female 5-12 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 20 mg/kg

SEX/DURATION :: female 5-12 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 165 mg/kg

SEX/DURATION :: female 8 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - Central Nervous System

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 90 mg/kg/3D (Continuous)

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 33,191,1995 *** REVIEWS *** TOXICOLOGY REVIEW FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 17,61,1979

α-卡茄碱安全信息

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
R63

[ 安全声明 (欧洲) ]:
22-36/37

[ 危险品运输编码 ]:
UN 1544

[ WGK德国 ]:
3

[ RTECS号 ]:
FL6700000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)