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相思子碱

相思子碱用途

(S)-Indoximod (1-Methyl-L-tryptophan) 是吲哚胺-2,3-双加氧酶 (IDO) 抑制剂。(S)-Indoximod 可用于癌症研究。

相思子碱名称

[ CAS 号 ]:
21339-55-9

[ 中文名 ]:
1-甲基-L-色氨酸

[ 英文名 ]:
(S)-Indoximod

[中文别名 ]:

[英文别名 ]:

1-Methyl-L-tryptophan
DL-1-Methyltryptophan
MFCD00467133
L-Tryptophan, 1-methyl-
1-methyl-(D,L)-tryptophan
1-Methyl-L-tryptophane
H-L-Trp(N-CH3)-OH
H-Trp(1-Me)-OH
BIDD:GT0440

相思子碱生物活性

[ 描述 ]:

(S)-Indoximod (1-Methyl-L-tryptophan) 是吲哚胺-2,3-双加氧酶 (IDO) 抑制剂。(S)-Indoximod 可用于癌症研究。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 代谢酶/蛋白酶 >> 吲哚胺2,3-二氧化酶(IDO)

[ 靶点 ]

Indoleamine 2,3-Dioxygenase (IDO)[1]

[参考文献]

[1]. Huang GL, et, al. PEG-Poly(1-Methyl-l-Tryptophan)-Based Polymeric Micelles as Enzymatically Activated Inhibitors of Indoleamine 2,3-Dioxygenase. Nanomaterials (Basel). 2019 May 9;9(5):719.

[2]. Liu X, et, al. 1-L-MT, an IDO inhibitor, prevented colitis-associated cancer by inducing CDC20 inhibition-mediated mitotic death of colon cancer cells. Int J Cancer. 2018 Sep 15;143(6):1516-1529.

相思子碱物理化学性质

[ 密度 ]:
1.28

[ 沸点 ]:
429.3±35.0 °C at 760 mmHg

[ 熔点 ]:
223-226 ºC

[ 分子式 ]:
C₁₂H₁₄N₂O₂

[ 分子量 ]:
218.252

[ 闪点 ]:
213.4±25.9 °C

[ 精确质量 ]:
218.105530

[ PSA ]:
68.25000

[ LogP ]:
1.43

[ 蒸汽压 ]:
0.0±1.1 mmHg at 25°C

[ 折射率 ]:
1.625

[ 储存条件 ]:
2-8°C

相思子碱MSDS

相思子碱毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YN7135000

CHEMICAL NAME :: L-Tryptophan, 1-methyl-

CAS REGISTRY NUMBER :: 21339-55-9

LAST UPDATED :: 198910

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C12-H14-N2-O2

MOLECULAR WEIGHT :: 218.28

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 286 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76- Volume(issue)/page/year: 1,515,1976

相思子碱安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
R20/21/22

[ 安全声明 (欧洲) ]:
36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
YN7135000

[ 海关编码 ]:
2933990090

相思子碱合成路线

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相思子碱上游产品

相思子碱下游产品

相思子碱海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

相思子碱文献

Human renal tubular epithelial cells suppress alloreactive T cell proliferation.

Clin. Exp. Immunol. 179(3) , 509-19, (2015)

Renal tubular epithelial cells (TECs) are one of the main targets of alloreactive T cells during acute rejection. We hypothesize that TECs modulate the outcome of alloimmunity by executing immunosuppr...

Induction of indoleamine 2,3-dioxygenase (IDO) enzymatic activity contributes to interferon-gamma induced apoptosis and death receptor 5 expression in human non-small cell lung cancer cells.

Asian Pac. J. Cancer Prev. 15(18) , 7995-8001, (2014)

Interferon-gamma (IFN-γ) has been used to treat various malignant tumors. However, the molecular mechanisms underlying the direct anti-proliferative activity of IFN-γ are poorly understood. In the pre...

Interferon gamma-mediated BoHV-4 replication restriction in bovine endometrial stromal cells is host IDO1 gene expression independent and BoHV-4 IE2 gene expression dependent.

Biol. Reprod. 91(5) , 112, (2014)

In the present work the interaction between bovine herpesvirus 4 (BoHV-4)-infected bovine endometrial stromal cells (BESCs) and interferon gamma (IFNG) was investigated. Starting from the particular t...

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