A-葡糖-A-葡糖苷

A-葡糖-A-葡糖苷用途

曲二糖是一种口服活性益生元双糖,能特异性抑制α-葡萄糖苷酶I的活性。曲二糖对双歧杆菌、乳酸菌和真细菌是一种增殖因子。曲二糖是一种低热量甜味剂,能够增加铁的吸收。Kojibios具有抗毒活性。Kojibios减少体内炎症标志物的肝脏表达[1][2]。

A-葡糖-A-葡糖苷名称

[ CAS 号 ]:
2140-29-6

[ 中文名 ]:
2-O-α-D-吡喃葡萄糖-D-葡萄糖

[ 英文名 ]:
Kojibiose

[中文别名 ]:

a-葡糖-a-葡糖苷

[英文别名 ]:

KOJIBIOSE
Glc1-|A-2Gal

A-葡糖-A-葡糖苷生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 感染

研究领域 >> 炎症/免疫

研究领域 >> 代谢疾病

[体内研究]

曲二糖 (0.5%；w/w每日摄入饮食; 持续 20天) 显着改善花生酸 (ARa；饮食每天 0.3毫克；持续 20天) 诱导的肝脏改变的严重程度[1]。动物模型：雌性Wistar白化大鼠,3周龄,使用链脲佐菌素(STZ；HY-13753),每天两次25 mg/kg,持续24小时[1]剂量：0.5%,w/w给药：饮食；结果：显著改善了花生酸(ARa；每天0.3mg,持续20d)诱导的肝脏改变的严重程度。与仅喂食ARa的人相比,PPARα的表达值显著增加,表明脂肪酸代谢增加。与只喂食ARa的动物相比,LPC和PS值降低。

[参考文献]

[1]. José Moisés Laparra, et al. Kojibiose ameliorates arachidic acid-induced metabolic alterations in hyperglycaemic rats. Br J Nutr. 2015 Nov 14;114(9):1395-402.

[2]. Miaomiao Wang, et al. Cloning and expression of the sucrose phosphorylase gene in Bacillus subtilis and synthesis of kojibiose using the recombinant enzyme. Microb Cell Fact. 2018 Feb 15;17(1):23.

A-葡糖-A-葡糖苷物理化学性质

[ 密度 ]:
1.68g/cm3

[ 沸点 ]:
783.7ºC at 760mmHg

[ 分子式 ]:
C₁₂H₂₂O₁₁

[ 分子量 ]:
342.29600

[ 闪点 ]:
292.1ºC

[ 精确质量 ]:
342.11600

[ PSA ]:
189.53000

[ 蒸汽压 ]:
0mmHg at 25°C

[ 折射率 ]:
1.652

[ 储存条件 ]:
-20°C

A-葡糖-A-葡糖苷MSDS

详细MSDS(安全技术说明书)

A-葡糖-A-葡糖苷安全信息

[ 危害码 (欧洲) ]:
Xi

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

A-葡糖-A-葡糖苷文献

Extracellular and cell-associated forms of Gluconobacter oxydans dextran dextrinase change their localization depending on the cell growth.

Biochem. Biophys. Res. Commun. 456(1) , 500-5, (2015)

Gluconobacter oxydans ATCC 11894 produces dextran dextrinase (DDase, EC 2.4.1.2), which synthesizes dextran from the starch hydrolysate, dextrin and is known to cause ropy beer. G. oxydans ATCC 11894 ...

Differentiation of Disaccharide Isomers by Temperature-Dependent In-Source Decay (TDISD) and DART-Q-TOF MS/MS.

J. Am. Soc. Mass Spectrom. 26 , 1599-605, (2015)

Helium direct analysis in real time (He-DART) mass spectrometry (MS) of some compounds, polysaccharides, for example, usually tends to be challenging because of the occurrence of prominent in-source d...

Microbial Communities Can Be Described by Metabolic Structure: A General Framework and Application to a Seasonally Variable, Depth-Stratified Microbial Community from the Coastal West Antarctic Peninsula.

PLoS ONE 10 , e0135868, (2015)

Taxonomic marker gene studies, such as the 16S rRNA gene, have been used to successfully explore microbial diversity in a variety of marine, terrestrial, and host environments. For some of these envir...

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