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波尔定碱 2-甲醚

波尔定碱 2-甲醚用途

月桂醇嗪(N-甲基月桂醇)是一种天然生物碱,是5-HT1A受体激动剂[1]。

波尔定碱 2-甲醚名称

[ CAS 号 ]:
2169-44-0

[ 中文名 ]:
波尔定碱 2-甲醚

[ 英文名 ]:
lauroscholtzine

[英文别名 ]:

Rogersine
lauroscholtzine
N-Methyllaurotetanine

波尔定碱 2-甲醚生物活性

[ 描述 ]:

月桂醇嗪(N-甲基月桂醇)是一种天然生物碱,是5-HT1A受体激动剂[1]。

[ 相关类别 ]:

研究领域 >> 神经疾病

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 5-HT受体

信号通路 >> 神经信号通路 >> 5-HT受体

[参考文献]

[1]. Sudharshan Madapa, et al. Semisynthetic Studies on and Biological Evaluation of N-Methyllaurotetanine Analogues as Ligands for 5-HT Receptors. J Nat Prod. 2015 Apr 24;78(4):722-9.

波尔定碱 2-甲醚物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
506.1±50.0 °C at 760 mmHg

[ 熔点 ]:
102.5°C

[ 分子式 ]:
C₂₀H₂₃NO₄

[ 分子量 ]:
341.401

[ 闪点 ]:
259.9±30.1 °C

[ 精确质量 ]:
341.162720

[ PSA ]:
51.16000

[ LogP ]:
3.09

[ 蒸汽压 ]:
0.0±1.4 mmHg at 25°C

[ 折射率 ]:
1.604

波尔定碱 2-甲醚毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CE1057900

CHEMICAL NAME :: 6a-alpha-Aporphin-9-ol, 1,2,10-trimethoxy-

CAS REGISTRY NUMBER :: 2169-44-0

LAST UPDATED :: 198208

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C20-H23-N-O4

MOLECULAR WEIGHT :: 341.44

WISWESSER LINE NOTATION :: T C6666 1A Q KN&TT&J EO1 FQ K1 PO1 QO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 450 mg/kg

TOXIC EFFECTS :: Cardiac - change in rate Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - other changes

REFERENCE :: APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 38,537,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 170 mg/kg

TOXIC EFFECTS :: Cardiac - change in rate Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - other changes

REFERENCE :: APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 38,537,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 90 mg/kg

TOXIC EFFECTS :: Cardiac - change in rate Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - other changes

REFERENCE :: APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 38,537,1980

波尔定碱 2-甲醚安全信息

[ 海关编码 ]:
2933990090

波尔定碱 2-甲醚海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%