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氧嗪酸钾

氧嗪酸钾用途

Oxonic acid钾盐是尿酸酶抑制剂,能抑制5-FU磷酸化为5-fluorouridine-5'-monophosphate。

氧嗪酸钾名称

[ CAS 号 ]:
2207-75-2

[ 中文名 ]:
氧嗪酸钾

[ 英文名 ]:
Potassium oxonate

[中文别名 ]:

[英文别名 ]:

Allantoxanic acid
Potassium Oxonate
Oxonic acid potassium salt
Oxonic acid
Potassium azaorotate
Oxonate
MFCD00010565
Potassium Allantoxanate
5-Aza-orotsaeure K-Salz
Allantoxanic Acid Potassium Salt

氧嗪酸钾生物活性

[ 描述 ]:

Oxonic acid钾盐是尿酸酶抑制剂,能抑制5-FU磷酸化为5-fluorouridine-5'-monophosphate。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 代谢疾病

[参考文献]

[1]. Shirasaka T, et al. Inhibition by oxonic acid of gastrointestinal toxicity of 5-fluorouracil without loss of its antitumor activity in rats. Cancer Res. 1993 Sep 1;53(17):4004-9.

[2]. Eraranta A, et al. Oxonic acid-induced hyperuricemia elevates plasma aldosterone in experimental renal insufficiency. J Hypertens. 2008 Aug;26(8):1661-8.

[相关活性小分子]

氧嗪酸钾物理化学性质

[ 熔点 ]:
300 °C(lit.)

[ 分子式 ]:
C₄H₂KN₃O₄

[ 分子量 ]:
195.175

[ 精确质量 ]:
194.968231

[ PSA ]:
118.74000

[ 外观性状 ]:
灰白色固体

[ 储存条件 ]:
Refrigerator, Under Inert Atmosphere

氧嗪酸钾MSDS

详细MSDS(安全技术说明书)

氧嗪酸钾毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RR4580000

CHEMICAL NAME :: Oxonic acid, potassium salt

CAS REGISTRY NUMBER :: 2207-75-2

LAST UPDATED :: 199704

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C4-H3-N3-O4.K

MOLECULAR WEIGHT :: 196.20

WISWESSER LINE NOTATION :: T6MVMVNJ FVO &-KA-

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 3 gm/kg

SEX/DURATION :: female 8-9 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Specific Developmental Abnormalities - body wall

REFERENCE :: TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 6,299,1976

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 4500 mg/kg

SEX/DURATION :: female 8-10 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - Central Nervous System

REFERENCE :: TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 6,299,1976

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 10800 ug/kg

SEX/DURATION :: female 9-11 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth)

REFERENCE :: TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 6,289,1976

氧嗪酸钾安全信息

[ 危害码 (欧洲) ]:
Xn

[ 安全声明 (欧洲) ]:
S24/25

[ WGK德国 ]:
3

[ RTECS号 ]:
RR4580000

[ 海关编码 ]:
2933699090

氧嗪酸钾合成路线

详细合成路线

氧嗪酸钾上下游产品

氧嗪酸钾上游产品

氧嗪酸钾下游产品

氧嗪酸钾海关

[ 海关编码 ]: 2933699090

[ 中文概述 ]:
2933699090 其他结构上含非稠合三嗪环化合物. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933699090 other compounds containing an unfused triazine ring (whether or not hydrogenated) in the structure。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:20.0%